Patents by Inventor Liana M. Lee
Liana M. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7767418Abstract: The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.Type: GrantFiled: May 15, 2008Date of Patent: August 3, 2010Assignee: Bristol-Myers Squibb CompanyInventors: Ning Lee, Jian Chen, John N. Feder, Shujian Wu, Liana M. Lee, Michael A. Blanar
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Patent number: 7741025Abstract: The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.Type: GrantFiled: September 10, 2007Date of Patent: June 22, 2010Assignee: Bristol-Myers Squibb CompanyInventors: John N. Feder, Shujian Wu, Thomas C. Nelson, Liana M. Lee
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Patent number: 7705134Abstract: The present invention provides novel polynucleotides encoding BGS-4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the polypeptides of the present invention. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.Type: GrantFiled: September 10, 2008Date of Patent: April 27, 2010Assignee: Bristol-Myers Squibb CompanyInventors: Shujian Wu, Stanley R. Krystek, Jr., Liana M. Lee, John N. Feder, Janet D. Cheng
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Patent number: 7521044Abstract: The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.Type: GrantFiled: August 1, 2006Date of Patent: April 21, 2009Assignee: Bristol-Myers Squibb CompanyInventors: Donald G. Jackson, Matthew V. Lorenzi, Liana M. Lee, John N. Feder
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Patent number: 7504481Abstract: The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.Type: GrantFiled: March 28, 2003Date of Patent: March 17, 2009Assignee: Bristol-Meyers Squibb CompanyInventors: Ning Lee, Jian Chen, John N. Feder, Shujian Wu, Liana M. Lee, Michael A. Blanar
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Patent number: 7456256Abstract: The present invention provides novel polynucleotides encoding BGS-2, 3, and 4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the polypeptides of the present invention. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-2, 3, and 4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.Type: GrantFiled: March 21, 2007Date of Patent: November 25, 2008Assignee: Bristol-Myers Squibb CompanyInventors: Shujian Wu, Stanley R. Krystek, Jr., Liana M. Lee, John N. Feder, Janet D. Cheng
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Publication number: 20080274505Abstract: The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.Type: ApplicationFiled: May 15, 2008Publication date: November 6, 2008Inventors: Ning Lee, Jian Chen, John N. Feder, Shujian Wu, Liana M. Lee, Michael A. Blanar, David Bol, Paul C. Lavesque, Lucy Sun
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Patent number: 7326781Abstract: The present invention describes a novel human protein kinase related to citron kinase, and its encoding polynucleotide. Also described are expression vectors, host cells, antisense molecules, and antibodies associated with the protein kinase polynucleotide and/or polypeptide of this invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders or diseases associated with abnormal biological activity of the protein kinase are described, as are methods for screening for modulators, e.g., agonists or antagonists, of the protein kinase activity and/or function.Type: GrantFiled: April 11, 2003Date of Patent: February 5, 2008Assignee: Bristol-Myers Squibb CompanyInventors: Daniel B. Davison, John N. Feder, Liana M. Lee, Karl-Heinz Ott
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Patent number: 7309779Abstract: The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.Type: GrantFiled: June 2, 2006Date of Patent: December 18, 2007Assignee: Bristol-Myers Squibb CompanyInventors: John N. Feder, Shujian Wu, Thomas C. Nelson, Liana M. Lee
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Patent number: 7273706Abstract: The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.Type: GrantFiled: July 31, 2006Date of Patent: September 25, 2007Assignee: Bristol-Myers Squibb CompanyInventors: John N. Feder, Shujian Wu, Thomas C. Nelson, Liana M. Lee
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Patent number: 7202056Abstract: The present invention provides novel polynucleotides encoding BGS-19 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying the novel BGS-19 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.Type: GrantFiled: March 28, 2003Date of Patent: April 10, 2007Assignee: Bristol-Myers Squibb CompanyInventors: Liana M. Lee, John N. Feder, Shujian Wu, Jian Chen
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Patent number: 7199227Abstract: The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.Type: GrantFiled: June 14, 2002Date of Patent: April 3, 2007Assignee: Bristol-Myers Squibb CompanyInventors: Donald G. Jackson, Matthew V. Lorenzi, Ricardo M. Attar, Marco Gottardis, Liana M. Lee, John N. Feder
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Publication number: 20040030098Abstract: The present invention provides novel polynucleotides encoding BGS-5G, and BGS-5I polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-5G, and BGS-5I polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.Type: ApplicationFiled: March 28, 2003Publication date: February 12, 2004Inventors: Liana M. Lee, John N. Feder, Nathan O. Siemers, Shujian Wu
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Publication number: 20040025195Abstract: The present invention provides novel polynucleotides encoding BGS-19 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying the novel BGS-19 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.Type: ApplicationFiled: March 28, 2003Publication date: February 5, 2004Inventors: Liana M. Lee, John N. Feder, Nathan O. Siemers, Shujian Wu, Jian Chen
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Publication number: 20040009915Abstract: The present invention describes the novel human intracellular chloride ion channel-related protein HCLI and its encoding polynucleotide. Also described are expression vectors, host cells, antisense molecules, and antibodies associated with the HCLI polynucleotide and/or polypeptide of this invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders or diseases associated with abnormal biological activity of HCLI are described, as are methods for screening for modulators, e.g., agonists or antagonists, of HCLI activity and/or function.Type: ApplicationFiled: March 6, 2003Publication date: January 15, 2004Inventors: Han Chang, John N. Feder, Liana M. Lee, Adam Rich
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Publication number: 20030224450Abstract: The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.Type: ApplicationFiled: March 28, 2003Publication date: December 4, 2003Inventors: Ning Lee, Jian Chen, John N. Feder, Shujian Wu, Liana M. Lee, Michael A. Blanar, David Bol, Paul C. Levesque, Lucy Sun
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Publication number: 20030220224Abstract: The present invention describes a novel human protein kinase related to citron kinase, and its encoding polynucleotide. Also described are expression vectors, host cells, antisense molecules, and antibodies associated with the protein kinase polynucleotide and/or polypeptide of this invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders or diseases associated with abnormal biological activity of the protein kinase are described, as are methods for screening for modulators, e.g., agonists or antagonists, of the protein kinase activity and/or function.Type: ApplicationFiled: April 11, 2003Publication date: November 27, 2003Inventors: Daniel B. Davison, John N. Feder, Liana M. Lee, Karl-Heinz Ott
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Publication number: 20030219774Abstract: The invention provides a novel human orphan neurotransmitter transporter belonging to the family of Na+/Cl− dependent transporters. Inventive HNTTBMY1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Further provided are methods for utilizing these polypeptides and polynucleotides in therapy and diagnostic assays for such. The transporter of the present invention is expressed highly in the amygdala brain subregion, which is known to be associated with affective disorders. The inventive transporter shares high homology with the rat orphan neurotransmitter transporter termed NTT4.Type: ApplicationFiled: December 13, 2002Publication date: November 27, 2003Inventors: Rahul Sharma, Chandra S. Ramanathan, Ryan Westphal, John N. Feder, Liana M. Lee
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Publication number: 20030181711Abstract: The present invention provides novel polynucleotides encoding K+Mbeta1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel K+Mbeta1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.Type: ApplicationFiled: October 3, 2002Publication date: September 25, 2003Inventors: John N. Feder, Liana M. Lee, Jian Chen, Donald Jackson, Chandra S. Ramanathan, Nathan O. Siemers, Han Chang
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Publication number: 20030162251Abstract: The present invention provides novel polynucleotides encoding K+betaM8 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel K+betaM8 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.Type: ApplicationFiled: September 4, 2002Publication date: August 28, 2003Inventors: John N. Feder, Liana M. Lee, Han Chang