Abstract: Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.

Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.

Abstract: The present invention provides recombinant Escherichia coli for producing glutarate, a construction method and use thereof. A double-plasmid recombinant bacterium is constructed through molecular biological means for co-expressing an aldehyde synthase (AAS) gene, an amine oxidase Mao (gene) and an aldehyde dehydrogenase (Glox) gene. The constructed expression plasmids are introduced into the Escherichia coli to reconstruct to obtain recombinant cells. A recombination strain for efficiently producing glutarate is obtained through amicillin resistance and kanamycin resistance combined plate screening. Efficient production of the glutarate is achieved by optimizing concentration of a substrate, cell concentration and a transformation temperature. L-lysine with a concentration of 30 g/L may be transformed into 19.

Abstract: The invention provides DNA molecules and constructs, and their nucleotide sequences, useful for modulating gene expression in plants, and for specifying intracellular or extracellular localization of a gene product of interest. Transgenic plants, plant cells, plant parts, and seeds, comprising the DNA molecules operably linked to heterologous transcribable polynucleotides are also provided.

Abstract: Provided are engineered ACE2 oligomers and compositions comprising the oligomers. Also provided are compositions and methods for treating or preventing coronavirus infection and detecting coronavirus.

Abstract: A database access method and apparatus are disclosed, to ensure data security during interaction between a user and a database, and effectively reduce performance overheads. The method includes: receiving an encrypted data computation request sent by a database kernel, where the encrypted data computation request requests to perform computation on encrypted data of a user, and the database kernel runs in a non-secure execution environment; receiving encrypted data sent by the database kernel, where the encrypted data is all encrypted data in a user query request; performing decryption and computation on the encrypted data in response to the encrypted data computation request, to obtain a computation result; encrypting the computation result to obtain an encrypted computation result; and sending the encrypted computation result to the database kernel.

Abstract: Described herein are ralinepag prodrugs, as well as pharmaceutical compositions thereof, and methods of use thereof in the treatment of diseases or conditions that would benefit from treatment with a prostacyclin (IP) receptor agonist compound, such as but not limited to pulmonary hypertension (PH) diseases.

Abstract: A photovoltaic module, including a plurality of solar cells each including a semiconductor substrate and a passivation layer, the semiconductor substrate is provided with an electrode including busbars, fingers, and electrode pads, each of the solar cells includes 9 to 20 busbars, each of the solar cells includes 40 to 100 fingers, and each of the busbars is connected to 3 to 10 electrode pads; a plurality of solder strips configured to connect the plurality of solar cells to each other, each of the solder strips fits the busbars and includes at least one boss portion soldered with the electrode pads, and a gradient of an outer surface of the boss portion along an extension direction of the solder strip ranges from 0° to 10°.

Abstract: The present application discloses a bionic induction type biological grouting device for uniformly reinforcing foundation soil, comprising an operation table, a rotating shaft and a rotating disc, at least two grouting pipes are arranged in a wall of a spiral guide pipe, a plurality of grout outlet holes are formed in an inner wall of the spiral guide pipe, a plurality of sets of grout spraying holes are formed in an outer wall of the spiral guide pipe in a rotation direction of the spiral guide pipe, and a plurality of adjusting components for controlling opening and closing of each set of grout spraying holes are arranged in the spiral guide pipe, and the plurality of adjusting components are linked through a flexible shaft.

Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.

Abstract: The present application discloses a bionic induction type biological grouting device for uniformly reinforcing foundation soil, comprising an operation table, a rotating shaft and a rotating disc, at least two grouting pipes are arranged in a wall of a spiral guide pipe, a plurality of grout outlet holes are formed in an inner wall of the spiral guide pipe, a plurality of sets of grout spraying holes are formed in an outer wall of the spiral guide pipe in a rotation direction of the spiral guide pipe, and a plurality of adjusting components for controlling opening and closing of each set of grout spraying holes are arranged in the spiral guide pipe, and the plurality of adjusting components are linked through a flexible shaft.

Abstract: Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.

Abstract: The present invention relates to a recombinant strain for producing shikimic acid, in which a target gene that regulates the asymmetric cell division and target genes that regulate the shikimic acid production are expressed The target gene that regulates the asymmetric cell division includes cytoskeletal protein PopZ coding gene popZ, and the target genes that regulate the shikimic acid production include DAHP synthase coding gene aroG, 3-dehydroquinate synthase coding gene aroB, and transketolase coding gene tktA. The recombinant strain of the present invention realizes the de novo synthesis of shikimic acid using glucose as a substrate, with a low cost. After fermentation with the strain in a 7.5 L fermentor, the highest production of shikimic acid is 88.1 g/L, the yield is 0.33 g/g, and the production intensity of shikimic acid is 1.1 g/L/h.

Abstract: The disclosure relates to a light train control system applied to oversea freight railways. The system integrates automatic block, station turnout control and train operation overspeed protection control and comprises an on-board subsystem, an RBC subsystem and a satellite positioning differential base station management subsystem, wherein the on-board subsystem is respectively connected to the RBC subsystem and the satellite positioning differential base station management subsystem.

Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.

Abstract: The application discloses a reversible plugging-type device for preventing seepage from a side wall of an irregular sample (14), comprising a sleeve (15) with both ends open, a primary lantern ring (4), a secondary lantern ring (5), a tertiary lantern ring (26) and a rotation shaft (1) arranged in a barrel (2), a lower end surface of the barrel (2) is provided with an annular floating plate (17), the primary lantern ring (4), the secondary lantern ring (5), and the tertiary lantern ring (26) are hollow, first phase liquid pipe (7) is arranged on a lower end surface of the primary lantern ring (4), second phase liquid pipe (8) is arranged on a lower end surface of the secondary lantern ring (5), the first phase liquid pipe (7) and the second phase liquid pipe (8) extend downward toward a mixing pipe (10). The floating plate (17) has the mixing pipe (10), which runs through the floating plate (17) and has a discharging pipe (22) provided with a discharge port (23).

Abstract: A fan device includes a hub and a plurality of fan blades. Each of the fan blades includes a driving surface, and the driving surface includes a first tooth column and a second tooth column. The first tooth column includes a plurality of first skin-tooth units. Each of the first skin-tooth units includes a first body. A first middle ridge and two first side ridges protrude from a surface of the first body, and a groove is formed between two adjacent first skin-tooth units. The second tooth column includes a plurality of second skin-tooth units. Each of the second skin-tooth units includes a second body and an extension element. A second middle ridge and two second side ridges protrude from a surface of the second body, and the extension element is located in the groove and includes an extension rib.

Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.