Abstract: The modified polypeptides include at least one amino acid substitution that allows the polypeptide to bind better to the S surface glycoprotein of coronaviruses that use ACE2 as a cell entry receptor, either through direct increases in affinity or through improved folding and expression of ACE2. Use of the modified ACE2 polypeptides for inhibiting CoV entry, replication and/or spread, for pre-exposure and post-exposure CoV prophylaxis, and for treating a CoV infection (e.g. COVTD-19), is also described.

Abstract: An implementation method and an application of a personalized presentation of associated multimedia content are provided. The method includes steps of: by a multimedia content provider, uniformly completing full file content when producing a multimedia file, and classifying segments of the content through a marking method according to an importance and/or an association degree of the content, so as to produce different versions of the multimedia file; and selectively previewing and/or playing by a user according to the different versions. The present invention is a flexible and efficient method for scalable organization, storage and transmission in an Internet on-demand system, thereby adding a flexible organization mechanism for the media content that an existing multimedia protocol lacks, and solving problems of an existing multimedia system, such as low transmission efficiency, waste of storage resources and poor user experience.

Abstract: An implementation method and an application of a personalized presentation of associated multimedia content are provided. The method includes steps of: by a multimedia content provider, uniformly completing full file content when producing a multimedia file, and classifying segments of the content through a marking method according to an importance and/or an association degree of the content, so as to produce different versions of the multimedia file; and selectively previewing and/or playing by a user according to the different versions. The present invention is a flexible and efficient method for scalable organization, storage and transmission in an Internet on-demand system, thereby adding a flexible organization mechanism for the media content that an existing multimedia protocol lacks, and solving problems of an existing multimedia system, such as low transmission efficiency, waste of storage resources and poor user experience.