Patents by Inventor Liangliang Qiang
Liangliang Qiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200132664Abstract: Example nanopore sequencers include a cis well, a trans well, and a nanopore fluidically connecting the cis and trans wells. In one example sequencer, a modified electrolyte (including an electrolyte and a cation complexing agent) is present in the cis well, or the trans well, or in the cis and the trans wells. In another example sequencer, a gel state polyelectrolyte is present in the cis well, or the trans well, or in the cis and the trans wells.Type: ApplicationFiled: June 19, 2018Publication date: April 30, 2020Inventors: Boyan Boyanov, Rohan N. Akolkar, Jeffrey S. Fisher, Jeffrey G. Mandell, Liangliang Qiang, Steven M. Barnard
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Patent number: 10633694Abstract: Under one aspect, a composition includes a substrate; a first polynucleotide coupled to the substrate; a second polynucleotide hybridized to the first polynucleotide; and a catalyst coupled to a first nucleotide of the second polynucleotide, the catalyst being operable to cause a chemiluminogenic molecule to emit a photon. Under another aspect, a method includes providing a catalyst operable to cause a first chemiluminogenic molecule to emit a photon; providing a substrate; providing a first polynucleotide coupled to the substrate; hybridizing a second polynucleotide to the first polynucleotide; coupling a first quencher to a first nucleotide of the second polynucleotide; and inhibiting, by the first quencher, photon emission by the first chemiluminogenic molecule.Type: GrantFiled: September 10, 2015Date of Patent: April 28, 2020Assignee: Illumina, Inc.Inventors: Boyan Boyanov, Liangliang Qiang, Kevin L. Gunderson, Kay Klausing, Lea Pickering, Cyril Delattre, Tarun Khurana
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Publication number: 20200009556Abstract: An interposer for a flow cell comprises a base layer having a first surface and a second surface opposite the first surface. The base layer comprises black polyethylene terephthalate (PET). A first adhesive layer is disposed on the first surface of the base layer. The first adhesive layer comprises methyl acrylic adhesive. A second adhesive layer is disposed on the second surface of the base layer. The second adhesive layer comprises methyl acrylic adhesive. A plurality of microfluidic channels extends through each of the base layer, the first adhesive layer, and the second adhesive layer.Type: ApplicationFiled: June 28, 2019Publication date: January 9, 2020Applicant: ILLUMINA, Inc.Inventors: Maxwell Zimmerley, LiangLiang Qiang, M. Shane Bowen, Steven H. Modiano, Dajun Yuan, Randall Smith, Arthur J. Pitera, Hai Quang Tran, Gerald Kreindl
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Patent number: 10519499Abstract: The disclosure provides detection apparatus having one or more nanopores, methods for making apparatus having one or more nanopore and methods for using apparatus having one or more nanopores. Uses include, but are not limited to detection and sequencing of nucleic acids.Type: GrantFiled: July 29, 2015Date of Patent: December 31, 2019Assignee: Illumina, Inc.Inventors: Boyan Boyanov, Jeffrey G Mandell, Kevin L Gunderson, Jingwei Bai, Liangliang Qiang, Bradley Baas
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Publication number: 20190383741Abstract: A device includes a plurality of imaging pixels in a spatial pattern with a formation of features disposed over the pixels. A first and a second feature of the formation of features are disposed over a first pixel. A first luminophore is disposed within or over the first feature. A second luminophore is disposed within or over the second feature. A structured illumination source is to direct at least a portion of first photons in an illumination pattern to the first feature at a first time, and to direct at least a portion of second photons in the illumination pattern to the second feature at a second time. The structured illumination source includes an illumination pattern generator having an illumination pattern generator actuator connected to the illumination pattern generator to cause the illumination pattern to translate or rotate relative to the formation of features.Type: ApplicationFiled: June 12, 2019Publication date: December 19, 2019Inventors: Dajun Yuan, Liangliang Qiang, Minghao Guo
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Publication number: 20190313956Abstract: Disclosed herein is a sensor comprising a conduit; the conduit comprising an organic polymer; a working electrode; the working electrode being etched and decorated with a nanostructured material; a reference electrode; and a counter electrode; the working electrode, the reference electrode and the counter electrode being disposed in the conduit; the working electrode, the reference electrode and the counter electrode being separated from each other by an electrically insulating material; and wherein a cross-sectional area of the conduit that comprises a section of the working electrode, a section of the reference electrode and a section of the counter electrode is exposed to detect analytes.Type: ApplicationFiled: June 3, 2019Publication date: October 17, 2019Inventors: Liangliang Qiang, Santhisagar Vaddiraju, Fotios Papadimitrakopoulos
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Patent number: 10314527Abstract: Disclosed herein is a sensor comprising a conduit; the conduit comprising an organic polymer; a working electrode; the working electrode being etched and decorated with a nanostructured material; a reference electrode; and a counter electrode; the working electrode, the reference electrode and the counter electrode being disposed in the conduit; the working electrode, the reference electrode and the counter electrode being separated from each other by an electrically insulating material; and wherein a cross-sectional area of the conduit that comprises a section of the working electrode, a section of the reference electrode and a section of the counter electrode is exposed to detect analytes.Type: GrantFiled: August 2, 2016Date of Patent: June 11, 2019Assignee: THE UNIVERSITY OF CONNECTICUTInventors: Liangliang Qiang, Santhisagar Vaddiraju, Fotios Papadimitrakopoulos
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Publication number: 20170356030Abstract: Under one aspect, a composition includes a substrate; a first polynucleotide coupled to the substrate; a second polynucleotide hybridized to the first polynucleotide; and a catalyst coupled to a first nucleotide of the second polynucleotide, the catalyst being operable to cause a chemiluminogenic molecule to emit a photon. Under another aspect, a method includes providing a catalyst operable to cause a first chemiluminogenic molecule to emit a photon; providing a substrate; providing a first polynucleotide coupled to the substrate; hybridizing a second polynucleotide to the first polynucleotide; coupling a first quencher to a first nucleotide of the second polynucleotide; and inhibiting, by the first quencher, photon emission by the first chemiluminogenic molecule.Type: ApplicationFiled: September 10, 2015Publication date: December 14, 2017Inventors: Boyan Boyanov, Liangliang Qiang, Kevin L. Gunderson, Kay Klausing, Lea Pickering, Cyril De Lattre, Tarun Khurana
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Publication number: 20170260582Abstract: The disclosure provides detection apparatus having one or more nanopores, methods for making apparatus having one or more nanopore and methods for using apparatus having one or more nanopores. Uses include, but are not limited to detection and sequencing of nucleic acids.Type: ApplicationFiled: July 29, 2015Publication date: September 14, 2017Inventors: BOYAN BOYANOV, JEFFREY G MANDELL, KEVIN L GUNDERSON, JINGWEI BAI, LIANGLIANG QIANG, BRADLEY BAAS
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Publication number: 20170156652Abstract: Disclosed herein is a sensor comprising a conduit; the conduit comprising an organic polymer; a working electrode; the working electrode being etched and decorated with a nanostructured material; a reference electrode; and a counter electrode; the working electrode, the reference electrode and the counter electrode being disposed in the conduit; the working electrode, the reference electrode and the counter electrode being separated from each other by an electrically insulating material; and wherein a cross-sectional area of the conduit that comprises a section of the working electrode, a section of the reference electrode and a section of the counter electrode is exposed to detect analytes.Type: ApplicationFiled: August 2, 2016Publication date: June 8, 2017Inventors: Liangliang Qiang, Santhisagar Vaddiraju, Fotios Papadimitrakopoulos
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Patent number: 9402574Abstract: Disclosed herein is a sensor comprising a conduit; the conduit comprising an organic polymer; a working electrode; the working electrode being etched and decorated with a nanostructured material; a reference electrode; and a counter electrode; the working electrode, the reference electrode and the counter electrode being disposed in the conduit; the working electrode, the reference electrode and the counter electrode being separated from each other by an electrically insulating material; and wherein a cross-sectional area of the conduit that comprises a section of the working electrode, a section of the reference electrode and a section of the counter electrode is exposed to detect analytes.Type: GrantFiled: June 20, 2011Date of Patent: August 2, 2016Assignees: THE UNIVERSITY OF CONNECTICUT, BIORASISInventors: Liangliang Qiang, Santhisagar Vaddiraju, Fotios Papadimitrakopoulos
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Patent number: 8778846Abstract: A composition includes a first probe, a first initiator component bonded to the first probe, a second probe, and a second initiator component bonded to the second probe. The first probe and the second probe are capable of binding to a single analyte, and the first initiator component and the second initiator component are capable of forming an initiator when present in proximity to each other and when the first probe and the second probe are bonded to the analyte. An associated kit, device, and method are provided.Type: GrantFiled: March 1, 2007Date of Patent: July 15, 2014Assignee: General Electric CompanyInventors: John Richard Nelson, Bahram Moasser, Anup Sood, Gregory Andrew Grossmann, Su Lu, Zhida Pan, Liangliang Qiang, John Yupeng Gui, Wei Cai, Zhixin Zheng
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Patent number: 8765643Abstract: The composition includes a first probe and a first initiator bonded to the first probe. The composition further includes a second probe and a second initiator bonded to the second probe. The first probe and the second probe are capable of binding to a single analyte. An associated kit, device, and method are provided.Type: GrantFiled: March 1, 2007Date of Patent: July 1, 2014Assignee: General Electric CompanyInventors: Zhida Pan, Su Lu, Liangliang Qiang, John Yupeng Gui, John Richard Nelson, Bahram Moasser, Anup Sood, Gregory Andrew Grossmann, Wei Cai, Zhixin Zheng
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Patent number: 8383337Abstract: A method includes binding a probe to an analyte present in a sample, wherein the probe comprises a binder bonded to a metal particle that is capable of releasing metal ions when contacted with a reagent solution. The method includes contacting the metal particle with the reagent solution to release the metal ions, and observing an optical signal from the released metal ions to determine a presence or amount of the analyte in the sample. An associated kit is also provided.Type: GrantFiled: July 18, 2008Date of Patent: February 26, 2013Assignee: General Electric CompanyInventors: Su Lu, Li Zhu, Zhida Pan, Liangliang Qiang, John Yupeng Gui
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Publication number: 20120122735Abstract: A composition includes a first probe, a first initiator component bonded to the first probe, a second probe, and a second initiator component bonded to the second probe. The first probe and the second probe are capable of binding to a single analyte, and the first initiator component and the second initiator component are capable of forming an initiator when present in proximity to each other and when the first probe and the second probe are bonded to the analyte. An associated kit, device, and method are provided.Type: ApplicationFiled: March 1, 2007Publication date: May 17, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: John Richard Nelson, Bahram Moasser, Anup Sood, Gregory Andrew Grossmann, Su Lu, Zhida Pan, Liangliang Qiang, John Yupeng Gui, Wei Cai, Zhixin Zheng
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Publication number: 20120122733Abstract: The composition includes a first probe and a first initiator bonded to the first probe. The composition further includes a second probe and a second initiator bonded to the second probe. The first probe and the second probe are capable of binding to a single analyte. An associated kit, device, and method are provided.Type: ApplicationFiled: March 1, 2007Publication date: May 17, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Zhida Pan, Su Lu, Liangliang Qiang, John Yupeng Gui, John Richard Nelson, Bahram Moasser, Anup Sood, Gregory Andrew Grossmann, Wei Cai, Zhixin Zheng
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Publication number: 20110315563Abstract: Disclosed herein is a sensor comprising a conduit; the conduit comprising an organic polymer; a working electrode; the working electrode being etched and decorated with a nanostructured material; a reference electrode; and a counter electrode; the working electrode, the reference electrode and the counter electrode being disposed in the conduit; the working electrode, the reference electrode and the counter electrode being separated from each other by an electrically insulating material; and wherein a cross-sectional area of the conduit that comprises a section of the working electrode, a section of the reference electrode and a section of the counter electrode is exposed to detect analytes.Type: ApplicationFiled: June 20, 2011Publication date: December 29, 2011Applicant: UNIVERSITY OF CONNECTICUTInventors: Liangliang Qiang, Santhisagar Vaddiraju, Fotios Papadimitrakopoulos
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Patent number: 7915318Abstract: A water soluble ROMP catalyst, which has high catalytic efficiency for ring opening metathesis is use in the preparation of polymeric blends for use in monolithic columns. In one embodiments a method for making a polymeric blend is discolosed comprising reaction of a water-soluble ROMP catalyst with a norbornene-substituted cycloolefin polymer or a polynorbornene polymer precursor, and wherein the contacting occurs in an aqueous or polar solvent in the presence of a solid support. In another embodiment a monolithic bed is disclosed comprising the water-soluble ROMP catalyst immobilized on a surface of a solid support. Also disclosed is a monolithic bed comprising: a polymer blend, the polymer blend produced from contacting a water soluble ROMP catalyst with a norbornene-substituted cycloolefin polymer or a polynorbornene polymer precursor; and wherein the contacting occurs in an aqueous or polar solvent in the presence of a solid support.Type: GrantFiled: September 9, 2008Date of Patent: March 29, 2011Assignee: General Electric CompanyInventors: Su Lu, Liangliang Qiang, Yanrong Zhu, Zhida Pan
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Publication number: 20100063200Abstract: A water soluble ROMP catalyst, which has high catalytic efficiency for ring opening metathesis is use in the preparation of polymeric blends for use in monolithic columns. In one embodiments a method for making a polymeric blend is discolosed comprising reaction of a water-soluble ROMP catalyst with a norbornene-substituted cycloolefin polymer or a polynorbornene polymer precursor, and wherein the contacting occurs in an aqueous or polar solvent in the presence of a solid support. In another embodiment a monolithic bed is disclosed comprising the water-soluble ROMP catalyst immobilized on a surface of a solid support. Also disclosed is a monolithic bed comprising: a polymer blend, the polymer blend produced from contacting a water soluble ROMP catalyst with a norbornene-substituted cycloolefin polymer or a polynorbornene polymer precursor; and wherein the contacting occurs in an aqueous or polar solvent in the presence of a solid support.Type: ApplicationFiled: September 9, 2008Publication date: March 11, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Su Lu, Liangliang Qiang, Yanrong Zhu, Zhida Pan
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Publication number: 20100015633Abstract: A method includes binding a probe to an analyte present in a sample, wherein the probe comprises a binder bonded to a metal particle that is capable of releasing metal ions when contacted with a reagent solution. The method includes contacting the metal particle with the reagent solution to release the metal ions, and observing an optical signal from the released metal ions to determine a presence or amount of the analyte in the sample. An associated kit is also provided.Type: ApplicationFiled: July 18, 2008Publication date: January 21, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Su Lu, Li Zhu, Zhida Pan, Liangliang Qiang, John Yupeng Gui