Patents by Inventor Lianhong Xu

Lianhong Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrimidine derivatives as HIV reverse transcriptase inhibitors
    Patent number: 8334295
    Abstract: The invention is related to compounds of Formula (I): or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: December 18, 2012
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Hongyan Guo, Choung U. Kim, Ill Y. Lee, Michael L. Mitchell, Gerry Rhodes, Jong C. Son, Lianhong Xu
  • ANTIVIRAL COMPOUNDS
    Publication number: 20120264711
    Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: June 7, 2012
    Publication date: October 18, 2012
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Hongyan Guo, Darryl Kato, Thorsten A. Kirschberg, Hongtao Liu, John O. Link, Michael L. Mitchell, Jay P. Parrish, Jianyu Sun, James Taylor, Elizabeth M. Bacon, Eda Canales, Aesop Cho, Choung U. Kim, Jeromy J. Cottell, Manoj C. Desai, Randall L. Halcomb, Michael Graupe, Evan S. Krygowski, Scott E. Lazerwith, Qi Liu, Richard L. Mackman, Hyung-Jung Pyun, Joseph H. Saugier, James D. Trenkle, Winston C. Tse, Randall W. Vivian, Scott D. Schroeder, William J. Watkins, Lianhong Xu
  • Antiviral compounds
    Patent number: 8273341
    Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: September 25, 2012
    Assignee: Gilead Sciences, Inc.
    Inventors: Hongyan Guo, Darryl Kato, Thorsten A. Kirschberg, Hongtao Liu, John O. Link, Michael L. Mitchell, Jay P. Parrish, Michael Graupe, Jianyu Sun, James Taylor, Elizabeth M. Bacon, Eda Canales, Aesop Cho, Choung U. Kim, Jeromy J. Cottell, Manoj C. Desai, Randall L. Halcomb, Evan S. Krygowski, Scott E. Lazerwith, Qi Liu, Richard Mackman, Hyung-Jun Pyun, Joseph H. Saugier, James D. Trenkle, Winston C. Tse, Randall W. Vivian, Scott D. Schroeder, William J. Watkins, Lianhong Xu
  • MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS
    Publication number: 20120237478
    Abstract: The present application provides for a compound of Formula IV, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
    Type: Application
    Filed: November 21, 2011
    Publication date: September 20, 2012
    Applicant: Gilead Sciences, Inc.
    Inventors: Manoj C. Desai, Allen Y. Hong, Hon C. Hui, Hongtao Liu, Randall W. Vivian, Lianhong Xu
  • ANTIVIRAL COMPOUNDS
    Publication number: 20120157404
    Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: November 8, 2011
    Publication date: June 21, 2012
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Hongyan Guo, Darryl Kato, Thorsten A. Kirschberg, Hongtao Liu, John O. Link, Michael L. Mitchell, Jay P. Parrish, Jianyu Sun, James Taylor, Elizabeth M. Bacon, Eda Canales, Aesop Cho, Choung U. Kim, Jeromy J. Cottell, Manoj C. Desai, Randall L. Halcomb, Michael Graupe, Evan S. Krygowski, Scott E. Lazerwith, Qi Liu, Richard L. Mackman, Hyung-Jung Pyun, Joseph H. Saugier, James D. Trenkle, Winston C. Tse, Randall W. Vivian, Scott D. Schroeder, William J. Watkins, Lianhong Xu
  • Modulators of pharmacokinetic properties of therapeutics
    Patent number: 8148374
    Abstract: The present application provides for a compound of Formula IV, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
    Type: Grant
    Filed: February 22, 2008
    Date of Patent: April 3, 2012
    Assignee: Gilead Sciences, Inc.
    Inventors: Manoj C. Desai, Hongtao Liu, Lianhong Xu
  • Pyrimidine-2,4-dione HIV reverse transcriptase inhibitors
    Patent number: 8106064
    Abstract: The invention is related to pyrimidine-2,4-dione HIV reverse transcriptase inhibitors of Formula (I), (II), or (III): or a pharmaceutically acceptable salt, thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
    Type: Grant
    Filed: July 24, 2007
    Date of Patent: January 31, 2012
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Hongyan Guo, Choung U. Kim, Thorsten A. Kirschberg, Ill Young Lee, Michael L. Mitchell, Jong Chan Son, Lianhong Xu
  • Modulators of pharmacokinetic properties of therapeutics
    Patent number: 8088770
    Abstract: The present application provides for a compound of Formula IV: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: January 3, 2012
    Assignee: Gilead Sciences, Inc.
    Inventors: Manoj C. Desai, Hon C. Hui, Hongtao Liu, Jianyu Sun, Lianhong Xu
  • Antiviral compounds
    Patent number: 8088368
    Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: January 3, 2012
    Assignee: Gilead Sciences, Inc.
    Inventors: Hongyan Guo, Darryl Kato, Thorsten A. Kirschberg, Hongtao Liu, John O. Link, Michael L. Mitchell, Jay P. Parrish, Jianyu Sun, James Taylor, Elizabeth M. Bacon, Eda Canales, Aesop Cho, Choung U. Kim, Jeromy J. Cottell, Manoj C. Desai, Randall L. Halcomb, Scott E. Lazerwith, Richard L. Mackman, Hyung-Jung Pyun, Joseph H. Saugier, James D. Trenkle, Winston C. Tse, William J. Watkins, Lianhong Xu
  • Modulators of pharmacokinetic properties of therapeutics
    Patent number: 8067449
    Abstract: The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: November 29, 2011
    Assignee: Gilead Sciences, Inc.
    Inventors: Manoj C. Desai, Allen Y. Hong, Hongtao Liu, Randall W. Vivian, Lianhong Xu
  • MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS
    Publication number: 20110212964
    Abstract: The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
    Type: Application
    Filed: May 9, 2011
    Publication date: September 1, 2011
    Applicant: Gilead Sciences, Inc.
    Inventors: Manoj C. Desai, Allen Yu Hong, Hongtao Liu, Randall W. Vivian, Lianhong Xu
  • Modulators of pharmacokinetic properties of therapeutics
    Patent number: 7939553
    Abstract: The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: May 10, 2011
    Assignee: Gilead Sciences, Inc.
    Inventors: Manoj C. Desai, Allen Yu Hong, Hongtao Liu, Randall W. Vivian, Lianhong Xu
  • Novel HIV reverse transcriptase inhibitors
    Publication number: 20110076276
    Abstract: The invention is related to compounds of Formula (I): or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
    Type: Application
    Filed: June 26, 2008
    Publication date: March 31, 2011
    Applicants: Gilead Sciences, Inc., Korean Research Institute of Chemical Technology
    Inventors: Hongyan Guo, Choung U. Kim, Ill Y. Lee, Michael L. Mitchell, Gerry Rhodes, Jong C. Son, Lianhong Xu
  • ANTIVIRAL COMPOUNDS
    Publication number: 20100310512
    Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: May 12, 2010
    Publication date: December 9, 2010
    Inventors: Hongyan Guo, Darryl Kato, Thorsten A. Kirschberg, Hongtao Liu, John O. Link, Michael L. Mitchell, Jay P. Parrish, Jianyu Sun, James Taylor, Elizabeth M. Bacon, Eda Canales, Aesop Cho, Choung U. Kim, Jeromy J. Cottell, Manoj C. Desai, Randall L. Halcomb, Michael Graupe, Evan S. Krygowski, Scott E. Lazerwith, Qi Liu, Richard L. Mackman, Hyung-Jun Pyun, Joseph H. Saugier, James D. Trenkle, Winston C. Tse, Randall W. Vivian, Scott D. Schroeder, William J. Watkins, Lianhong Xu
  • MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS
    Publication number: 20100189687
    Abstract: The present application provides for a compound of Formula IV, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
    Type: Application
    Filed: February 22, 2008
    Publication date: July 29, 2010
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Manoj C. Desai, Allen Y. Hong, Hon Chung Hui, Hongtao Liu, Randall W. Vivian, Lianhong Xu
  • AZA-peptide protease inhibitors
    Patent number: 7741345
    Abstract: The invention is related to compounds of Formula I: or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: June 22, 2010
    Assignee: Gilead Sciences, Inc.
    Inventors: Carina E. Cannizzaro, James M. Chen, Manoj C. Desai, Michael L. Mitchell, Sundaramoorthi Swaminathan, Lianhong Xu
  • Antiviral protease inhibitors
    Patent number: 7723380
    Abstract: The invention is related to compounds of Formula I: or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: May 25, 2010
    Assignee: Gilead Sciences, Inc.
    Inventors: Carina E. Cannizzaro, James M. Chen, Manoj C. Desai, Michael L. Mitchell, Sundaramoorthi Swaminathan, Lianhong Xu, Zheng-Yu Yang
  • NOVEL HIV REVERSE TRANSCRIPTASE INHIBITORS
    Publication number: 20100034827
    Abstract: The invention is related to compounds of Formula (I), (II), or (III); or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
    Type: Application
    Filed: July 24, 2007
    Publication date: February 11, 2010
    Applicants: GILEAD SCIENCES, INC., KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Hongyan Guo, Choung U. Kim, Thorsten A. Kirschberg, Iii Young Lee, Michael L. Mitchell, Jong Chan Son, Lianhong Xu
  • Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds
    Patent number: 7649015
    Abstract: Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: January 19, 2010
    Assignee: Gilead Sciences, Inc.
    Inventors: Murty N. Arimili, Xiaowu Chen, Maria Fardis, Gong-Xin He, Haolun Jin, Choung U. Kim, William A. Lee, Kuei-Ying Lin, Hongtao Liu, Richard L. Mackman, Michael L. Mitchell, Hyung-Jung Pyun, Mark Sparacino, Sundaramoorthi Swaminathan, Jianying Wang, Matthew A. Williams, Lianhong Xu, Zheng-Yu Yang, Richard H. Yu, Jiancun Zhang, Lijun Zhang
  • THERAPEUTIC COMPOUNDS AND METHODS
    Publication number: 20090312318
    Abstract: The present invention provides compounds of Formula (I): wherein A, X, Q, R2-R6, m, and W have the values described herein, as well as compositions comprising such compounds. The compounds are protease inhibitors and are useful for inhibiting the development of drug resistance in animals.
    Type: Application
    Filed: July 24, 2007
    Publication date: December 17, 2009
    Inventors: Manoj C. Desai, Christopher P. Lee, Hongtao Liu, Sundaramoorthi Swaminathan, Lianhong Xu