Abstract: Cycloalkyl and hetero-cycloalkyl inhibitors, preparation methods therefor, and the use thereof are described. Compounds of the present invention have a structure represented by formula (I). Further disclosed are preparation methods for said compounds, and the use of said compounds as KRASG12C inhibitors. The compounds have an excellent ability to selectively inhibit KRASG12C, improved pharmacodynamic and pharmacokinetic performance, and reduced toxic side effects.

Abstract: Methods and apparatuses for voice over long-term evolution/voice over new radio (VoLTE/VoNR) performance for a cellular communication system. A method of operating a base station includes receiving, from a user equipment (UE), uplink (UL)signals; identifying, based on the UL signals, a first and second parameters; determining first and second UL power control parameters based on the first and second parameters, respectively; determining a first time period for the first UL power control parameter and a second time period for the second UL power control parameter, wherein the first time period is longer than the second time period; updating the first UL power control parameter based on the first time period and the second UL power control parameter based on the second time period; and transmitting, to the UE, the updated first and second UL power control parameters for an UL transmit power of the UE.

Abstract: A three-dimensional target, a wheel positioning system, and a wheel positioning method are provided. The three-dimensional target includes a base body. The base body is provided with at least three target surfaces which are all in different planes. Each of the at least three target surfaces is provided with target elements. Each of the at least three target surfaces is used for wheel positioning. Two of the at least three target surfaces form a group of calculation units, and the spatial position relationship between the target elements of at least two groups of calculation units is used for determining the position of a wheel. By using two target surfaces as a group, the at least three target surfaces can be configured into multiple groups, and calibration is performed according to the multiple target surfaces; thus, the accuracy of calibration calculation is improved.

Abstract: Disclosed are a calibration system (600a) and a calibration support (100a) therefor. The calibration support (100a) comprises: a base (10); a vertical frame assembly (20a), comprising a fixed vertical rod (22) and a movable vertical rod (24), wherein the fixed vertical rod (22) is mounted on the base (10), and the movable vertical rod (24) is capable of moving, within a preset range relative to the base (10), in the length direction of the fixed vertical rod (22); and a cross beam (30a), which is detachably mounted to one of a first mounting seat (35a) and a second mounting seat (36a) which are connected to the movable vertical rod (24), the cross beam (30a) being used for mounting a calibration element, and the calibration element being used for calibrating an advanced driver assistant system of a vehicle.

Abstract: A calibration bracket (100), comprising: a base (10); a stand component (20) connected to the base (10); a cross beam component (30, 30?) mounted to the stand component (20) and used for mounting a calibration element, which is used for calibrating an advanced driver assistant system of a vehicle; and a rotating component (40) mounted between the stand component (20) and the base (10), and used for driving the stand component (20) to pivot about a central axis of the stand component (20) relative to the base (10) so as to adjust an angle of rotation of the cross beam component (30, 30) relative to the central axis of the stand component (20). According to the structure, an angle of rotation of the cross beam component (30, 30?) relative to the central axis of the stand component (20) can be adjusted, so that the rotation of the cross beam component (30, 30?) is free from the mounting position. The calibration bracket is simple in structure, and convenient to carry.

Abstract: A calibration support includes a support body (100) configured to mount a calibration element, the calibration element being configured to calibrate a driving assistance system of a vehicle (500); an image acquisition device (200) connected to the support body (100) and configured to acquire an image of the vehicle (500); a processing device (300) provided on the support body (100), electrically connected to the image acquisition device (200), and configured to calculate, according to the image acquired by the image acquisition device (200), the movement position of the support body (100) relative to the vehicle (500) and output a control signal comprising the movement position; and a control device (400) provided on the support body (100), electrically connected to the processing device (300), and configured to receive the control signal and control the support body (100) to move.

Abstract: A calibration system and a calibration bracket thereof. The calibration bracket includes: a base; a fixed vertical rod, one end of the fixed vertical rod being mounted on the base; a movable vertical rod, mounted on the fixed vertical rod, and being able to move relative to the fixed vertical rod along a length direction of the fixed vertical rod; a brake member, configured to provide a friction force for driving the movable vertical rod to be fixed relative to the fixed vertical rod along the length direction of the fixed vertical rod; and a hanging member, mounted on the movable vertical rod, the hanging member being used for hanging a calibration element, the calibration element being used for calibrating an advanced driver assistance system of a vehicle.

Abstract: A processing cartridge, detachably installed in an electronic image forming device that includes a first pushing element and a second pushing element. The processing cartridge includes a developing roller and a first housing supporting the developing roller; a photo-sensitive drum and a second housing supporting the photo-sensitive drum; a first force receiving element, configured to be abutted against the second pushing element to separate the developing roller from the photo-sensitive drum; and a second force receiving element, configured to be abutted against the first pushing element for enabling the second force receiving element to push the first force receiving element to rotate about an axis. A rotation axis of the first force receiving portion is substantially perpendicular to a direction in which the processing cartridge is installed into or taken out of the electronic image forming device.

Abstract: The present invention relates to the technical field of electrocatalytic electrode preparation, and discloses a lead dioxide-carbon nanotube adsorptive electrochemical submicroelectrode, a preparation method, and use thereof. The electrochemical submicroelectrode according to the present invention comprises multiple layers of orderly arranged spherical lead dioxide submicroholes communicating with each other, where the carbon nanotubes are partially or completely inserted (in the form of twigs) in the lead dioxide hole and in the wall of the hole. The combined effect of adsorption and catalysis inside the submicroreactor effectively solves the problems of low catalytic efficiency and diffusion control associated with the conventional flat lead dioxide electrode, thus greatly improving the electrochemical catalytic performance of the electrode.

Abstract: Cycloalkyl and hetero-cycloalkyl inhibitors, preparation methods therefor, and the use thereof are described. Compounds of the present invention have a structure represented by formula (I). Further disclosed are preparation methods for said compounds, and the use of said compounds as KRASG12C inhibitors. The compounds have an excellent ability to selectively inhibit KRASG12C, improved pharmacodynamic and pharmacokinetic performance, and reduced toxic side effects.

Abstract: Provided are a synchronous fluorescence detector for observing the interface concentration of fluorescent pollutants and application method. The detector comprises a first electric displacement platform, a quartz cuvette, an excitation light path, a collection light path and a second electric displacement platform. The application method comprises the following steps: first exciting fluorescent pollutants by utilizing UV light with specific wavelengths to emit fluorescent light; then collecting fluorescence signals emitted by the excited fluorescent pollutants to the greatest extent by utilizing an UV anti-reflection convex lens combination; and finally, processing the fluorescent signals acquired by a photomultiplier by utilizing a difference method to determine a precise light intensity of a thin layer which is moved at a specific spacing by utilizing the electric displacement platforms so as to determine fugacity distribution of the fluorescent pollutants in the microlayer near an interface.

Abstract: A device includes a substrate, a first electrode formed on the substrate and a structural layer formed on the substrate. The structural layer includes a movable mass and a fixed portion, the movable mass being suspended above the substrate and the first electrode being interposed between the substrate and the movable mass. A second electrode is spaced apart from an upper surface of the movable mass by a gap and an anchor couples the second electrode to the fixed portion of the structural layer. A method entails integrating formation of the second electrode into a wafer process flow in which the first electrode and the structural layer are formed.

Abstract: A wafer includes a process control monitor (PCM) structure formed on a substrate. The PCM structure includes detection and reference structures. The detection structure includes a first electrically conductive line arrangement formed in a first structural layer on the substrate and a first protection layer surrounding the first electrically conductive line arrangement. The reference structure includes a second electrically conductive line arrangement formed in the first structural layer on the substrate, a second protection layer surrounding the second electrically conductive line arrangement, an insulator material formed overlying the second electrically conductive line arrangement and the second protection layer, and a second structural layer overlying the insulator material. The insulator material does not overlie the detection structure.

Abstract: Provided are a BCMA-targeting engineered immune cell and the use thereof. In particular, a CAR specifically targeting BCMA is provided. In the CAR, an antigen binding domain contained therein is a J-derived scFv, having an antibody heavy-chain variable region shown in SEQ ID NO: 9, and an antibody light-chain variable region shown in SEQ ID NO: 10. Also provided are a CAR-T cell containing the CAR, and a duplex CAR and CAR T cells containing the J-derived scFv, and related uses thereof. Compared with CAR-T cells constructed by using other scFvs, the CAR-T cells constructed by the present invention have higher killing effects and tumor clearance ability.

Abstract: Related are a calibration device (100), a calibration system, and a calibration method in the technical fields of vehicle maintenance and device calibration. A calibration element (20) is mounted on a main frame (10), the calibration element (20) being used for calibrating a sensor (30) of an advanced driver assistant system of a vehicle (200). When in use, the main frame (10) is positioned in a first preset position in the vicinity of at least one wheel hub of the vehicle (200), and by determining the position to place the main frame (10) on the basis of the position of the wheel hub, a lot of time wasted for scribing measurement is saved, thereby providing a calibration device (100), a calibration system, and a calibration method which are easy to operate with increased work efficiency.

Abstract: The disclosure relates to the technical field of automobile maintenance and repair as well as device calibration, and in particular, to a bracket apparatus. The bracket apparatus includes a base, a vertical rod and a clamping assembly. One end of the vertical rod is mounted to the base. The clamping assembly is mounted to the vertical rod. The clamping assembly includes a sliding member, a push rod assembly, a handle and an elastic member. One end of the sliding member is sleeved on the vertical rod. The sliding member is movable along the vertical rod. An other end of the sliding member is configured to carry a calibration element. The push rod assembly can be movably mounted to the sliding member in a preset direction. Two ends of the elastic member respectively abut against an inner wall of the sliding member and the push rod assembly. The elastic member can drive one end of the push rod assembly to be tightly pressed against the vertical rod.

Abstract: A calibration device is provided. The calibration device includes a laser assembly, a calibration bracket and a magnetic element. The calibration bracket includes a loading platform which is configured to support the laser assembly. The magnetic element is mounted on one of the laser assembly and the loading platform, and is configured to attract the other of the laser assembly and the loading platform. By means of arranging the magnetic element on one of the loading platform and the laser assembly, the magnetic element can attract the other of the loading platform and the laser assembly, so that when the laser assembly needs to be mounted on the loading platform, the laser assembly only needs to approach the loading platform and the laser assembly will be attracted to the loading platform due to the magnetic force provided by the magnetic element.

Abstract: A processing cartridge is provided. The processing cartridge can be detachably mounted in an electronic imaging device including a driving component for transmitting rotating force. The processing cartridge includes a housing and a force receiving element. The force receiving element including force receiving parts is disposed at one side of the housing and is rotatably supported by the housing. The force receiving parts are disposed at an end portion of the force receiving element along a circumferential direction of the force receiving element and protrude in a direction of a rotation axis of the force receiving element. When the processing cartridge is mounted in the electronic imaging device along a predetermined mounting direction, the force receiving parts and the driving component are engaged with each other to transmit the force.

Abstract: The present invention discloses an electrocatalytic Fenton oxidation-electrochemical oxidation coupling process and apparatus for efficient treatment of chemical wastewater, and belongs to the field of sewage treatment. The process includes an electrocatalytic Fenton oxidation step, an electrochemical oxidation step, and a pH adjustment step. A spacing between a cathode and an anode in the electrocatalytic Fenton oxidation step is controlled, so that oxygen produced at the anode reacts at the cathode to produce H2O2. The treatment requirements can be met without external aeration or external addition of H2O2, and meanwhile, the efficiency of COD removal by electro-Fenton oxidation is effectively improved.

Abstract: The present invention provides an engineered immune cell targeting BCMA and use thereof. In particular, the present invention provides a CAR specifically targeting BCMA, the CAR comprising an antigen-binding domain which is an S-derived scFv, an antibody heavy chain variable region as shown in SEQ ID NO: 9 and an antibody light chain variable region as shown in SEQ ID NO: 10. The present invention also provides a CAR-T cell comprising the CAR, a double CAR- and CAR-T cell comprising the S-derived scFv, and related use thereof. Compared to CAR-T cells constructed using other scFvs, the constructed CAR-T cell of the present invention has a better killing effect and tumor elimination capability.