Patents by Inventor Liaohai Chen
Liaohai Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150086976Abstract: A method for determining the presence or concentration of an analyte in a sample is described, including the steps of associating an initiator with the analyte to form an analyte associated initiator, contacting the analyte associated initiator with a reagent adapted to undergo a self-catalytic reaction which produces a product, and obtaining an observation or measurement corresponding to a change in the amount of the product. Kits and additional methods related to analyte detection are also described.Type: ApplicationFiled: September 22, 2014Publication date: March 26, 2015Applicant: UTAH STATE UNIVERSITYInventor: Liaohai Chen
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Patent number: 8835805Abstract: The invention provides a simple and inexpensive method to assemble nanomaterials into millimeter lengths. The method can be used to generate optical, sensing, electronic, magnetic and or catalytic materials. Also provided is a substrate comprised of fused nanoparticles. The invention also provides a diode comprised of assembled nanoparticles.Type: GrantFiled: September 30, 2011Date of Patent: September 16, 2014Assignee: UChicago Argonne, LLCInventors: John T. Bahns, Liaohai Chen, Stephen K. Gray, Subramanian Sankaranarayanan
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Publication number: 20130084451Abstract: The invention provides a simple and inexpensive method to assemble nanomaterials into millimeter lengths. The method can be used to generate optical, sensing, electronic, magnetic and or catalytic materials. Also provided is a substrate comprised of fused nanoparticles. The invention also provides a diode comprised of assembled nanoparticles.Type: ApplicationFiled: September 30, 2011Publication date: April 4, 2013Applicant: UCHICAGO ARGONNE, LLCInventors: John T. Bahns, Liaohai Chen, Stephen K. Gray, Subramanian Sankaranarayanan
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Patent number: 7229837Abstract: A particulate fluorescent conjugated polymer surfactant complex and method of making and using same. The particles are between about 15 and about 50 nm and when formed from a lipsome surfactant have a charge density similar to DNA and are strongly absorbed by cancer cells.Type: GrantFiled: May 30, 2003Date of Patent: June 12, 2007Assignee: UChicago Argonne, LLCInventor: Liaohai Chen
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Publication number: 20060240456Abstract: Nanosized biological containers that are “ghosts” of viruses for which capsids are independent of their endogenous viral nucleic acid cores, provide nano-particles of uniform size, and known numbers of sites for attachments of ligands. These containers can be filled with a fluorescent, magnetic, x-ray absorbent, nucleotide components or a radioactive particle and used as nanoscale markers.Type: ApplicationFiled: March 20, 2006Publication date: October 26, 2006Inventors: Liaohai Chen, Samuel Bader, Axel Hoffmann, Brian Kay, Lee Makowski
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Patent number: 6979543Abstract: A sensor is provided including a polymer capable of having an alterable measurable property from the group of luminescence and electrical conductivity, the polymer having an intermediate combination of a recognition element, a tethering element and a property-altering element bound thereto and capable of altering the measurable property, the intermediate combination adapted for subsequent separation from the polymer upon exposure to an agent having an affinity for binding to the recognition element whereupon the separation of the intermediate combination from the polymer results in a detectable change in the alterable measurable property, and, detecting said detectable change in the alterable measurable property.Type: GrantFiled: April 10, 2003Date of Patent: December 27, 2005Assignee: The Regents of the University of CaliforniaInventors: Liaohai Chen, Duncan W. McBranch, Hsing-Lin Wang, David G. Whitten
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Publication number: 20040214220Abstract: The present invention provides a method of detecting a biological agent including contacting a sample with a sensor including a polymer system capable of having an alterable measurable property from the group of luminescence, anisotropy, redox potential and uv/vis absorption, the polymer system including an ionic conjugated polymer and an electronically inert polyelectrolyte having a biological agent recognition element bound thereto, the electronically inert polyelectrolyte adapted for undergoing a conformational structural change upon exposure to a biological agent having affinity for binding to the recognition element bound to the electronically inert polyelectrolyte, and, detecting the detectable change in the alterable measurable property. A chemical moiety being the reaction product of (i) a polyelectrolyte monomer and (ii) a biological agent recognition element-substituted polyelectrolyte monomer is also provided.Type: ApplicationFiled: May 18, 2004Publication date: October 28, 2004Inventor: Liaohai Chen
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Patent number: 6780379Abstract: A device for detecting volatile chemical reagents based on fluorescence quenching analysis that is capable of detecting neutral electron acceptor molecules. The device includes a fluorescent material, a contact region, a light source, and an optical detector. The fluorescent material includes at least one polymer-surfactant complex. The polymer-surfactant complex is formed by combining a fluorescent ionic conjugated polymer with an oppositely charged surfactant. The polymer-surfactant complex may be formed in a polar solvent and included in the fluorescent material as a solution. Alternatively, the complex may be included in the fluorescent material as a thin film. The use of a polymer-surfactant complex in the fluorescent material allows the device to detect both neutral and ionic acceptor molecules. The use of a polymer-surfactant complex film allows the device and the fluorescent material to be reusable after exposing the fluorescent material to a vacuum for limited time.Type: GrantFiled: November 2, 2001Date of Patent: August 24, 2004Assignee: The Regents of the University of CaliforniaInventors: Liaohai Chen, Duncan McBranch, Rong Wang, David Whitten
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Patent number: 6737279Abstract: The present invention provides a method of detecting a biological agent including contacting a sample with a sensor including a polymer system capable of having an alterable measurable property from the group of luminescence, anisotropy, redox potential and uv/vis absorption, the polymer system including an ionic conjugated polymer and an electronically inert polyelectrolyte having a biological agent recognition element bound thereto, the electronically inert polyelectrolyte adapted for undergoing a conformational structural change upon exposure to a biological agent having affinity for binding to the recognition element bound to the electronically inert polyelectrolyte, and, detecting the detectable change in the alterable measurable property. A chemical moiety being the reaction product of (i) a polyelectrolyte monomer and (ii) a biological agent recognition element-substituted polyelectrolyte monomer is also provided.Type: GrantFiled: March 28, 2001Date of Patent: May 18, 2004Assignee: The Regents of the University of CaliforniaInventor: Liaohai Chen
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Publication number: 20040023272Abstract: A sensor is provided including a polymer capable of having an alterable measurable property from the group of luminescence and electrical conductivity, the polymer having an intermediate combination of a recognition element, a tethering element and a property-altering element bound thereto and capable of altering the measurable property, the intermediate combination adapted for subsequent separation from the polymer upon exposure to an agent having an affinity for binding to the recognition element whereupon the separation of the intermediate combination from the polymer results in a detectable change in the alterable measurable property, and, a means of detecting said detectable change in the alterable measurable property.Type: ApplicationFiled: April 10, 2003Publication date: February 5, 2004Inventors: Liaohai Chen, Duncan W. McBranch, Hsing-Lin Wang, David G. Whitten
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Publication number: 20030224525Abstract: A particulate fluorescent conjugated polymer surfactant complex and method of making and using same. The particles are between about 15 and about 50 nm and when formed from a lipsome surfactant have a charge density similar to DNA and are strongly absorbed by cancer cells.Type: ApplicationFiled: May 30, 2003Publication date: December 4, 2003Applicant: The University of ChicagoInventor: Liaohai Chen
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Patent number: 6589731Abstract: A sensor element is provided including a polymer exhibiting a measurable property from the group of luminescence and electrical conductivity, the polymer being complexed with a unit including a recognition element, a tethering element and a property-altering element bound thereto so as to alter the measurable property, the unit being susceptible of subsequent separation from the polymer upon exposure to an agent having an affinity for binding to the recognition element whereupon the separation of the unit from the polymer results in a detectable change in the measurable property.Type: GrantFiled: May 4, 2000Date of Patent: July 8, 2003Assignee: The Regents of the University of CaliforniaInventors: Liaohai Chen, Duncan W. McBranch, Hsing-Lin Wang, David G. Whitten
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Patent number: 6569952Abstract: The addition of oppositely charged surfactant to fluorescent ionic conjugated polymer forms a polymer-surfactant complex that exhibits at least one improved photophysical property. The conjugated polymer is a fluorescent ionic polymer that typically has at least one ionic side chain or moiety that interacts with the specific surfactant selected. The photophysical property improvements may include increased fluorescence quantum efficiency, wavelength-independent emission and absorption spectra, and more stable fluorescence decay kinetics. The complexation typically occurs in a solution of a polar solvent in which the polymer and surfactant are soluble, but it may also occur in a mixture of solvents. The solution is commonly prepared with a surfactant molecule:monomer repeat unit of polymer ratio ranging from about 1:100 to about 1:1. A polymer-surfactant complex precipitate is formed as the ratio approaches 1:1. This precipitate is recoverable and usable in many forms.Type: GrantFiled: September 5, 2001Date of Patent: May 27, 2003Assignee: The Regents of the University of CaliforniaInventors: Liaohai Chen, Su Xu, Duncan McBranch, David Whitten