Patents by Inventor Lieve Emma Jan Michiels

Lieve Emma Jan Michiels has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Entry inhibitors of the HIV virus
    Patent number: 8268885
    Abstract: The present invention relates to small molecules as entry inhibitors of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors with other anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: September 18, 2012
    Assignee: Janssen R&D Ireland
    Inventors: Koenraad Lodewijk August Van Acker, Piet Tom Bert Paul Wigerinck, Lieve Emma Jan Michiels, Abdellah Tahri
  • Small molecule entry inhibitors
    Patent number: 7429677
    Abstract: The present invention concerns a compound having the formula (I) a N-oxide form, a stereochemical isomer, racemic mixture, salt, prodrug, ester or metabolite thereof. It further relates to processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors with anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.
    Type: Grant
    Filed: March 11, 2003
    Date of Patent: September 30, 2008
    Assignee: Tibotec Pharmaceuticals Ltd.
    Inventors: Marie-Pierre T. M. M. G De Bethune, Sandra De Meyer, Kurt Hertogs, Rong Jian Lu, Lieve Emma Jan Michiels, Abdellah Tahri, Dong Xie, Michael Eissenstat
  • (1,10B-Dihydro-2-(aminocarbonyl-phenyl)-5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors
    Patent number: 7326703
    Abstract: The present invention realtes to 5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as inhibitors of the viral replication of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present HIV inhibitors with other anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: February 5, 2008
    Assignee: Tibotec Pharmaceuticals Ltd
    Inventors: Abdellah Tahri, Lieve Emma Jan Michiels, Koenraad Lodewijk August Van Acker, Dominique Louis Nestor Ghislain Surleraux
  • Methods and means for assessing HIV envelope inhibitor therapy
    Patent number: 7306901
    Abstract: The present invention relates to methods and products for the evaluation of HIV treatment. In particular, molecular events at the HIV envelope protein and their effect on therapeutic efficacy of drugs are determined. The methods rely on providing HIV envelope nucleic acid material and evaluating a treatment either through genotyping or phenotyping. Said method may find use in multiple fields including diagnostics, drug screening, pharmacogenetics and drug development.
    Type: Grant
    Filed: August 8, 2002
    Date of Patent: December 11, 2007
    Assignee: Tibotec Pharmaceuticals, Ltd.
    Inventors: Sharon Kemp, Johan Hendrika Jozef Vingerhoets, Lieve Emma Jan Michiels
  • (1,10B-Dihydro-2-(Aminocarbonyl-Phenyl)-5h-Pyrazolo[1,5-C][1,3]Benzoxazin-5-Yl)Phenyl Methanone Derivatives as Hiv Viral Replication Inhibitors
    Publication number: 20070248624
    Abstract: The present invention relates to 5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as inhibitors of the viral replication of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present HIV inhibitors with other anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.
    Type: Application
    Filed: May 4, 2005
    Publication date: October 25, 2007
    Inventors: Abdellah Tahri, Lieve Emma Jan Michiels, Koenraad Van Acker, Dominique Louis Nestor Ghislain Surleraux
  • Methods of assessing HIV integrase inhibitor therapy
    Patent number: 7189505
    Abstract: The present invention relates to methods and products for the evaluation of HIV treatment. The methods are based on evaluating molecular events at the HIV integrase resulting in altered therapeutic efficacy of the investigated compounds. The methods rely on providing an integrase gene and evaluating either through genotyping or phenotyping the integrase gene. The present invention relates to the fields of diagnostics, drug screening, pharmacogenetics and drug development.
    Type: Grant
    Filed: August 15, 2005
    Date of Patent: March 13, 2007
    Assignee: Tibotec BVBA
    Inventors: Johan Hendrika Jozef Vingerhoets, Lieve Emma Jan Michiels, Inge Dierynck
  • Methods of assessing HIV integrase inhibitor therapy
    Patent number: 6958211
    Abstract: Methods and products for the evaluation of HIV treatment are provided. The methods are based on evaluating molecular events at the HIV integrase resulting in altered therapeutic efficacy of tho investigated compounds. The methods rely on providing an integrase gene and evaluating either through integrase gene genotyping or phenotyping.
    Type: Grant
    Filed: August 8, 2002
    Date of Patent: October 25, 2005
    Assignee: Tibotech BVBA
    Inventors: Johan Hendrika Jozef Vingerhoets, Lieve Emma Jan Michiels, Inge Dierynck
  • Methods and means for assessing HIV envelope inhibitor therapy
    Publication number: 20030180715
    Abstract: The present invention relates to methods and products for the evaluation of HIV treatment. In particular, molecular events at the HIV envelope protein and their effect on therapeutic efficacy of drugs are determined. The methods rely on providing HIV envelope nucleic acid material and evaluating a treatment either through genotyping or phenotyping. Said method may find use in multiple fields including diagnostics, drug screening, pharmacogenetics and drug development.
    Type: Application
    Filed: August 8, 2002
    Publication date: September 25, 2003
    Inventors: Sharon Kemp, Johan Hendrika Jozef Vingerhoets, Lieve Emma Jan Michiels
  • Methods of assessing HIV integrase inhibitor therapy
    Publication number: 20030124514
    Abstract: The present invention relates to methods and products for the evaluation of HIV treatment. The methods are based on evaluating molecular events at the HIV integrase resulting in altered therapeutic efficacy of the investigated compounds. The methods rely on providing an integrase gene and evaluating either through genotyping or phenotyping said integrase gene. The present invention relates to the fields of diagnostics, drug screening, pharmacogenetics and drug development.
    Type: Application
    Filed: August 8, 2002
    Publication date: July 3, 2003
    Inventors: Johan Hendrika Jozef Vingerhoets, Lieve Emma Jan Michiels, Inge Dierynck