Patents by Inventor Lihui WEI

Lihui WEI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IDENTIFICATION AND TREATMENT OF VULNERABLE PLAQUES
    Publication number: 20160324992
    Abstract: A method of detecting an atherosclerotic plaque vulnerable to rupture in a subject comprises providing to the subject a labelled necrostatin or a derivative thereof, and visualizing the label, wherein a localization of the label in a plaque indicates the plaque is vulnerable to rupture. A method of detecting and treating an atherosclerotic plaque vulnerable to rupture comprises providing to the subject a labelled necrostatin or a derivative thereof, visualizing the label, wherein a localization of the label in a plaque indicates the plaque is vulnerable to rupture; and providing a necroptosis inhibitor or derivative thereof to the subject when the visualizing indicates that the plaque is vulnerable to rupture. The necroptosis inhibitor may comprise a necrostatin, such as Nec-1. The label may be a radiolabel such as 123I. By visualizing plaques vulnerable to rupture, atherosclerotic plaques may be identified and treated in advance of rupture.
    Type: Application
    Filed: May 5, 2016
    Publication date: November 10, 2016
    Inventors: Katey J. RAYNER, Terrence David RUDDY, Denuja KARUNAKARAN, Lihui WEI
  • Radiolabelled rotenone derivatives and their use in SPECT imaging
    Patent number: 9133208
    Abstract: The present application discloses a compound of formula (I) or (II): wherein X is gamma-emitting radionuclide. Also disclosed is a pharmaceutical composition comprising the compound of formula (I), the compound of formula (II), or a mixture thereof, and a physiologically acceptable vehicle and a method of imaging a region in a patient, which includes administering to the patient a diagnostically effective amount of the pharmaceutical composition comprising the compound of formula (I), the compound of formula (II), or a mixture thereof.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: September 15, 2015
    Assignee: NORDION (CANADA) INC.
    Inventors: Lihui Wei, Xuxu Yan, Corinne Bensimon, Terrence David Ruddy
  • RADIOLABELLED ROTENONE DERIVATIVES AND THEIR USE IN SPECT IMAGING
    Publication number: 20130022542
    Abstract: The present application discloses a compound of formula (I) or (II): wherein X is gamma-emitting radionuclide. Also disclosed is a pharmaceutical composition comprising the compound of formula (I), the compound of formula (II), or a mixture thereof, and a physiologically acceptable vehicle and a method of imaging a region in a patient, which includes administering to the patient a diagnostically effective amount of the pharmaceutical composition comprising the compound of formula (I), the compound of formula (II), or a mixture thereof.
    Type: Application
    Filed: July 13, 2012
    Publication date: January 24, 2013
    Applicant: NORDION (CANADA) INC.
    Inventors: Lihui WEI, Xuxu Yan, Corinne Bensimon, Terrence David Ruddy