Abstract: A trust rule between a first service and a second service in a plurality of services deployed in a distributed system is received; the trust rule defines whether the first service is allowed to access the second service. A trust tree is obtained for the distributed system, and the trust tree comprises a plurality of certificates for accessing the plurality of services. A first group of certificates is selected for the first service based on the trust rule and the trust tree, and the first group of certificates enables the first service to access the second service.

Abstract: A recombinant virus vector comprising a heterologous nucleic acid segment encoding FRNK protein (including active fragments thereof) operably linked to regulatory sequences directing expression of said FRNK protein in a cell susceptible to infection by said DNA virus vector is disclosed. Also disclosed is isolated mammalian FRNK protein, along with nucleic acids encoding the same and expression cassettes containing such nucleic acids. Methods of using the foregoing to induce the death of tumor cells are disclosed.