Patents by Inventor Lili Arabshahi
Lili Arabshahi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10876939Abstract: An apparatus for pretreatment of a sample of whole blood in a discrete fluid analyzing instrument comprises automated means for handling and analyzing the sample and means for performing a pretreatment step on the sample or a sub-sample of the sample. The means for pretreatment are used for immobilizing at least one substance or analyte from the sample or sub-sample wherein the substance or analyte is reversibly immobilized. Usually, the apparatus further comprises means for eluting the substance or analyte from the capture means prior to analysis.Type: GrantFiled: December 20, 2017Date of Patent: December 29, 2020Assignee: Thermo Fisher Scientific OyInventors: Sari Tikanoja, Annu Suoniemi, Johan Finell, Lili Arabshahi
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Publication number: 20180120204Abstract: An apparatus for pretreatment of a sample of whole blood in a discrete fluid analyzing instrument comprises automated means for handling and analyzing the sample and means for performing a pretreatment step on the sample or a sub-sample of the sample. The means for pretreatment are used for immobilizing at least one substance or analyte from the sample or sub-sample wherein the substance or analyte is reversibly immobilized. Usually, the apparatus further comprises means for eluting the substance or analyte from the capture means prior to analysis.Type: ApplicationFiled: December 20, 2017Publication date: May 3, 2018Inventors: Sari Tikanoja, Annu Suoniemi-Kähärä, Johan Finell, Lili Arabshahi
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Patent number: 9891149Abstract: A method for pretreatment of a sample of whole blood in a discrete fluid analyzing instrument comprises automated means for handling and analyzing the sample and means for performing a pretreatment step on the sample or a sub-sample of the sample. The means for pretreatment are used for immobilizing at least one substance or analyte from the sample or sub-sample wherein the substance or analyte is reversibly immobilized. Usually, the apparatus further comprises means for eluting the substance or analyte from the capture means prior to analysis.Type: GrantFiled: August 7, 2012Date of Patent: February 13, 2018Assignee: Thermo Fisher Scientific OyInventors: Sari Tikanoja, Annu Suoniemi-Kähärä, Johan Finell, Lili Arabshahi
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Publication number: 20160025753Abstract: Immunoassays, methods, and kits for qualitative and/or quantitative detection of cannabinoids in specimens including, without limitation, bodily fluids (e.g., blood, urine, oral fluid or sweat) or other biological specimens and potential drug samples.Type: ApplicationFiled: July 22, 2015Publication date: January 28, 2016Inventors: Parisa Khosropour, Haijuan Li, Concord Cheung, Anlong Ouyang, Lili Arabshahi
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Patent number: 8846411Abstract: Levetiracetam (LEV) derivatives, methods for synthesizing LEV derivatives, and immunodiagnostic assays for LEV. The synthesis methods described herein include chirally-selective, liquid-phase synthesis steps to produce selected LEV derivatives in high-yield. LEV derivatives can include operative groups, such as: immunogenic moieties that can be used to prepare anti-LEV antibodies; antigenic moieties that can be used in immunodiagnostic assays for LEV; or tracer moieties that can be used in immunodiagnostic assays. Additionally, the LEV derivatives can be used in immunodiagnostic assays to compete with LEV for anti-LEV antibodies.Type: GrantFiled: June 9, 2010Date of Patent: September 30, 2014Assignee: Microgenics CorporationInventors: Anlong Ouyang, Aniruddha Patwardhan, Lili Arabshahi
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Patent number: 8592564Abstract: Generally, the present invention relates to lamotrigine analogs that have substituents at the triazine 3-position and on the benzene 4-position and 5-position. The lamotrigine analogs can include immunogenic moieties that can be used to prepare anti-lamotrigine antibodies, or antigenic moieties that can be used in immunodiagnostic assays for lamotrigine. Also, the lamotrigine analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the lamotrigine analogs can be used in immunodiagnostic assays to compete with lamotrigine for binding with anti-lamotrigine antibodies.Type: GrantFiled: January 25, 2010Date of Patent: November 26, 2013Assignee: Seradyn, Inc.Inventors: Anlong Ouyang, Lili Arabshahi, Mark Roberts, Melissa Wall
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Publication number: 20130040307Abstract: A method and apparatus for pretreatment of a sample of whole blood in a discrete fluid analyzing instrument comprises automated means for handling and analyzing the sample and means for performing a pretreatment step on the sample or a sub-sample of the sample. The means for pretreatment are used for immobilizing at least one substance or analyte from the sample or sub-sample wherein the substance or analyte is reversibly immobilized. Usually, the apparatus further comprises means for eluting the substance or analyte from the capture means prior to analysis.Type: ApplicationFiled: August 7, 2012Publication date: February 14, 2013Applicant: THERMO FISHER SCIENTIFIC OYInventors: Sari TIKANOJA, Annu SUONIEMI-KÄHÄRÄ, Johan FINELL, Lili ARABSHAHI
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Publication number: 20100317024Abstract: Levetiracetam (LEV) derivatives, methods for synthesizing LEV derivatives, and immunodiagnostic assays for LEV. The synthesis methods described herein include chirally-selective, liquid-phase synthesis steps to produce selected LEV derivatives in high-yield. LEV derivatives can include operative groups, such as: immunogenic moieties that can be used to prepare anti-LEV antibodies; antigenic moieties that can be used in immunodiagnostic assays for LEV; or tracer moieties that can be used in immunodiagnostic assays. Additionally, the LEV derivatives can be used in immunodiagnostic assays to compete with LEV for anti-LEV antibodies.Type: ApplicationFiled: June 9, 2010Publication date: December 16, 2010Inventors: Anlong Ouyang, Aniruddha Patwardhan, Lili Arabshahi
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Publication number: 20100209416Abstract: Generally, the present invention relates to lamotrigine analogs that have substituents at the triazine 3-position and on the benzene 4-position and 5-position. The lamotrigine analogs can include immunogenic moieties that can be used to prepare anti-lamotrigine antibodies, or antigenic moieties that can be used in immunodiagnostic assays for lamotrigine. Also, the lamotrigine analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the lamotrigine analogs can be used in immunodiagnostic assays to compete with lamotrigine for binding with anti-lamotrigine antibodies.Type: ApplicationFiled: January 25, 2010Publication date: August 19, 2010Applicant: Serydyn, Inc.Inventors: Anlong Ouyang, Lili Arabshahi, Mark Roberts, Melissa Wall
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Patent number: 7678551Abstract: Generally, the present invention relates to lamotrigine analogs that have substituents at the triazine 3-position and on the benzene 4-position and 5-position. The lamotrigine analogs can include immunogenic moieties that can be used to prepare anti-lamotrigine antibodies, or antigenic moieties that can be used in immunodiagnostic assays for lamotrigine. Also, the lamotrigine analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the lamotrigine analogs can be used in immunodiagnostic assays to compete with lamotrigine for binding with anti-lamotrigine antibodies.Type: GrantFiled: October 20, 2005Date of Patent: March 16, 2010Assignee: Seradyn, Inc.Inventors: Anlong Ouyang, Lili Arabshahi, Mark Roberts, Melissa Wall
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Patent number: 7655429Abstract: Topiramate analogs have substituents at the sulfamate group, 9-position, or 10-position. Topiramate analogs may include immunogenic moieties to prepare anti-topiramate antibodies, or antigenic moieties for immunodiagnostic assays. Also, the topiramate analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the topiramate analogs can be used in immunodiagnostic assays to compete with topiramate for binding with anti-topiramate antibodies. Such an immunodiagnostic assay can be used for detecting the presence of topiramate in a sample obtained from a subject previously administered topiramate by the following: combining an anti-topiramate antibody and a topiramate analog with a sample to form a first composition; allowing any free topiramate from the sample and the topiramate analog to compete for binding with the antibody; detecting binding between the topiramate analog and the antibody.Type: GrantFiled: September 20, 2007Date of Patent: February 2, 2010Assignee: Seradyn, Inc.Inventors: Anlong Ouyang, Lili Arabshahi
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Patent number: 7638291Abstract: Generally, the present invention relates to topiramate analogs that have substituents at the sulfamate group or at the 9-position or 10-position. The topiramate analogs can include immunogenic moieties that can be used to prepare anti-topiramate antibodies, or antigenic moieties that can be used in immunodiagnostic assays for topiramate. Also, the topiramate analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the topiramate analogs can be used in immunodiagnostic assays to compete with topiramate for binding with anti-topiramate antibodies.Type: GrantFiled: October 20, 2005Date of Patent: December 29, 2009Assignee: Seradyn, Inc.Inventors: Anlong Ouyang, Lili Arabshahi
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Publication number: 20080009018Abstract: Topiramate analogs have substituents at the sulfamate group, 9-position, or 10-position. Topiramate analogs may include immunogenic moieties to prepare anti-topiramate antibodies, or antigenic moieties for immunodiagnostic assays. Also, the topiramate analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the topiramate analogs can be used in immunodiagnostic assays to compete with topiramate for binding with anti-topiramate antibodies. Such an immunodiagnostic assay can be used for detecting the presence of topiramate in a sample obtained from a subject previously administered topiramate by the following: combining an anti-topiramate antibody and a topiramate analog with a sample to form a first composition; allowing any free topiramate from the sample and the topiramate analog to compete for binding with the antibody; detecting binding between the topiramate analog and the antibody.Type: ApplicationFiled: September 20, 2007Publication date: January 10, 2008Applicant: SERADYN, INC.Inventors: Anlong Ouyang, Lili Arabshahi
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Patent number: 7271252Abstract: The invention provides derivatives of efavirenz and methods of making derivatives of efavirenz. The derivatives include immunogenic compounds for producing antibodies to efavirenz and labeled efavirenz tracers. These compounds are useful in immunoassay methods for determining efavirenz.Type: GrantFiled: April 22, 2003Date of Patent: September 18, 2007Assignee: Roche Diagnostics Operations, Inc.Inventors: Gerald F. Sigler, Mitali Ghoshal, Lili Arabshahi
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Publication number: 20070148684Abstract: A non-isotopic immunoassay for an HIV protease inhibitor comprising incubating a sample containing the inhibitor with a receptor specific for the inhibitor or for a metabolite of said inhibitor and further with a conjugate comprising an analog of the inhibitor and a non-isotopic signal generating moiety.Type: ApplicationFiled: February 9, 2007Publication date: June 28, 2007Inventors: Salvatore Salamone, Gerald Sigler, Lili Arabshahi
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Patent number: 7223553Abstract: Immunoassays for the detection of everolimus are provided. Compounds for producing antibodies for everolimus, as well as antibodies produced therefrom, are also provided.Type: GrantFiled: February 13, 2006Date of Patent: May 29, 2007Inventors: Mark Roberts, Lili Arabshahi, Jared Boyd, Christopher T. Dennis, Peter Marbach, George Aaron, Deng Hwang, Alexei Boris Shvets
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Publication number: 20060172356Abstract: Generally, the present invention relates to lamotrigine analogs that have substituents at the triazine 3-position and on the benzene 4-position and 5-position. The lamotrigine analogs can include immunogenic moieties that can be used to prepare anti-lamotrigine antibodies, or antigenic moieties that can be used in immunodiagnostic assays for lamotrigine. Also, the lamotrigine analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the lamotrigine analogs can be used in immunodiagnostic assays to compete with lamotrigine for binding with anti-lamotrigine antibodies.Type: ApplicationFiled: October 20, 2005Publication date: August 3, 2006Inventors: Anlong Ouyang, Lili Arabshahi, Mark Roberts, Melissa Wall
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Publication number: 20060141548Abstract: Immunoassays for the detection of everolimus are provided. Compounds for producing antibodies for everolimus, as well as antibodies produced therefrom, are also provided.Type: ApplicationFiled: February 13, 2006Publication date: June 29, 2006Inventors: Mark Roberts, Lili Arabshahi, Jared Boyd, Christopher Dennis, Peter Marbach, George Aaron, Deng Hwang, Alexei Shvets
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Publication number: 20060127938Abstract: A non-isotopic immunoassay for an HIV protease inhibitor comprising incubating a sample containing the inhibitor with a receptor specific for the inhibitor or for a metabolite of said inhibitor and further with a conjugate comprising an analog of the inhibitor and a non-isotopic signal generating moiety. Signal generated as a result of binding of the inhibitor by the receptor is measured and correlated with the presence or amount of protease inhibitor in the original sample.Type: ApplicationFiled: January 26, 2006Publication date: June 15, 2006Inventors: Salvatore Salamone, Gerald Sigler, Lili Arabshahi
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Publication number: 20060115865Abstract: Generally, the present invention relates to lamotrigine analogs that have substituents at the triazine 3-position and on the benzene 4-position and 5-position. The lamotrigine analogs can include immunogenic moieties that can be used to prepare anti-lamotrigine antibodies, or antigenic moieties that can be used in immunodiagnostic assays for lamotrigine. Also, the lamotrigine analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the lamotrigine analogs can be used in immunodiagnostic assays to compete with lamotrigine for binding with anti-lamotrigine antibodies.Type: ApplicationFiled: October 20, 2005Publication date: June 1, 2006Inventors: Anlong Ouyang, Lili Arabshahi, Mark Roberts