Patents by Inventor Lili He

Lili He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210293566
    Abstract: The present application relates to the technical field of intelligent transportation, electronic map, and positioning and navigation and, in particular, to a navigation map evaluation method and apparatus, a device and a readable storage medium. The electronic device acquires a travelling simulation video of the road section to be tested and a real environment image of each location point on the road section to be tested, generates a linkage video according to the navigation simulation image and the real environment image of each location point on the road section to be tested, and evaluates a first map according to the linkage video. In the process, the navigation map is evaluated through a way of simulation, which achieves the purpose of reducing the cost of manpower and material resources in the process of the navigation map evaluation.
    Type: Application
    Filed: June 4, 2021
    Publication date: September 23, 2021
    Applicant: Beijing Baidu Netcom Science Technology Co., Ltd.
    Inventors: Lili HE, Hongfei ZHU, Peng YANG
  • Publication number: 20210181115
    Abstract: The present disclosure provides a surface enhanced Raman scattering substrate assembly for detecting an analyte. The assembly can include an etched fiber base. The assembly can further include a metallic nanoparticle coating disposed over at least a portion of the surface etched fiber base.
    Type: Application
    Filed: February 3, 2021
    Publication date: June 17, 2021
    Inventors: Lili He, Haoxin Chen, Zhuansheng Lin
  • Patent number: 10942124
    Abstract: The present disclosure provides a surface enhanced Raman scattering substrate assembly for detecting an analyte. The assembly can include an etched fiber base. The assembly can further include a metallic nanoparticle coating disposed over at least a portion of the surface etched fiber base.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: March 9, 2021
    Assignee: University of Massachusetts
    Inventors: Lili He, Haoxin Chen, Zhuangsheng Lin
  • Patent number: 10921257
    Abstract: The present disclosure provides a method for mapping one or more analytes that contact a biological structure. The method uses surface-enhanced Raman spectroscopy and includes contacting the biological structure and a metallic nanoparticle. The method further includes collecting a spectrum with a Raman spectrometer. The method further includes determining a location of the analyte along at least one of an x-direction, a y-direction and a z-direction on the structure.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: February 16, 2021
    Assignee: University of Massachusetts
    Inventor: Lili He
  • Publication number: 20210030301
    Abstract: A method for detecting blood-tissue barrier breakdown or disruption is provided. The method includes acquiring first image data of a target region of a subject with a predetermined spatial resolution; administrating exogenous or endogenous tracer into the subject; acquiring second image data of the target region with the predetermined spatial resolution after administration of the tracer; differentiating healthy tissue and pathological tissue with blood-tissue barrier breakdown in the target region based on the first image data and the second image data; and visualizing or analyzing the blood-tissue barrier breakdown of pathological tissue based on the differentiation.
    Type: Application
    Filed: February 7, 2019
    Publication date: February 4, 2021
    Inventors: Jinghua Wang, Lili He
  • Publication number: 20200302602
    Abstract: A system for objectively analyzing medical image data for the presence of diffuse white matter abnormalities (DWMA) is configured to identify and determine DWMA characteristics that are not visually apparent. As compared to subjective visual diagnosis, objectively determined DWMA characteristics may be automatically compared to each other, and may be compared to and associated with various scales, evaluations, or other assessment criteria used to measure aspects of infant development. As a result, the disclosed system may objectively determine an impact that objectively determined DWMA characteristics will have on one or more developmental scales, which can be expressed as a time deficit, score deficit, or other value indicative of development deficits.
    Type: Application
    Filed: March 19, 2020
    Publication date: September 24, 2020
    Inventors: Nehal Parikh, Lili He
  • Publication number: 20200003773
    Abstract: The present disclosure provides a substrate. The substrate includes a metallic layer. The substrate further includes a boronic acid component, a nucleic acid component, or both at least partially coating the metallic layer.
    Type: Application
    Filed: April 4, 2019
    Publication date: January 2, 2020
    Inventors: Lili He, Brooke Pearson
  • Publication number: 20190383747
    Abstract: The present disclosure provides a surface enhanced Raman scattering substrate assembly for detecting an analyte. The assembly can include an etched fiber base. The assembly can further include a metallic nanoparticle coating disposed over at least a portion of the surface etched fiber base.
    Type: Application
    Filed: June 12, 2019
    Publication date: December 19, 2019
    Inventors: Lili He, Haoxin Chen, Zhuangsheng Lin
  • Patent number: 10444311
    Abstract: Techniques for optimizing a magnetic resonance imaging (MRI) protocols are described herein. An example method can include receiving one or more MRI scanner settings for an imaging sequence; selecting at least one objective function from a plurality of objective functions; selecting an acquisition train length; selecting a k-space strategy; selecting one or more imaging parameters; and acquiring a magnetic resonance (MR) image using at least one of an optimized k-space strategy, an optimized acquisition train length, or optimized imaging parameters.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: October 15, 2019
    Assignees: Ohio State Innovation Foundation, Research Institute at Nationwide Children's Hospital
    Inventors: Jinghua Wang, Zhong-lin Lu, Nehal Parikh, Lili He
  • Patent number: 10241053
    Abstract: A bacterial detection platform integrating the sensitive SERS technique and the advanced mapping technique. Bacterial cells on the SERS substrate are detected using the mapping technique. The identification is based on the fingerprint of the bacterial SERS spectra. The quantification of the cells is based on the mapping technique. For different applications, silver or gold nanoparticles can be integrated onto a filter membrane for concentration and detection of bacterial cells in water or silver dendrites can be used as the SERS substrate. The SERS substrates are also modified with capturers and fixed in a vessel to concentrate cells from complex liquid matrices.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: March 26, 2019
    Assignee: University of Massachusetts
    Inventor: Lili He
  • Publication number: 20180321156
    Abstract: Various embodiments disclosed relate to a substrate. The present disclosure provides a substrate for use in surface enhanced spectroscopy. The substrate includes a polymeric membrane, a semi-conductive coating on the polymeric membrane, and a plurality of metallic nanoparticles on the semi-conducive coating.
    Type: Application
    Filed: May 4, 2018
    Publication date: November 8, 2018
    Inventors: Lili He, Chen Tan
  • Patent number: 10045705
    Abstract: Disclosed is a hand-held, medical, multi-channel biological information acquisition mobile terminal system, comprising two signal sensing gloves RL with a cable end embedded therein, for use in acquiring a variety of biological signals comprising multi-channel interconnected ECG, heart sounds, finger blood volume pulse, and skin impedance etc., the signal sensing gloves RL also comprising a signal acquisition device S, a signal transmission device C connected to the signal acquisition device S, and a mobile terminal T connected wirelessly or with a wired connection. The system has the characteristics of low power consumption, small size, low cost and fewer control channels needed for multi-channel connection; and the system can achieve on-site acquisition of a variety of biological information and the mobile function of electronic health records.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: August 14, 2018
    Assignee: DONGGUAN MATHEMATICAL ENGINEERING ACADEMY OF CHINESE MEDICINE AND GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE AND GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
    Inventors: Zhiwei Liang, Zhangjin Su, Lili He, Xiaoping Lai
  • Publication number: 20180113075
    Abstract: The present disclosure provides a method for mapping one or more analytes that contact a biological structure. The method uses surface-enhanced Raman spectroscopy and includes contacting the biological structure and a metallic nanoparticle. The method further includes collecting a spectrum with a Raman spectrometer. The method further includes determining a location of the analyte along at least one of an x-direction, a y-direction and a z-direction on the structure.
    Type: Application
    Filed: October 25, 2017
    Publication date: April 26, 2018
    Inventor: Lili He
  • Publication number: 20180045799
    Abstract: Techniques for optimizing a magnetic resonance imaging (MRI) protocols are described herein. An example method can include receiving one or more MRI scanner settings for an imaging sequence; selecting at least one objective function from a plurality of objective functions; selecting an acquisition train length; selecting a k-space strategy; selecting one or more imaging parameters; and acquiring a magnetic resonance (MR) image using at least one of an optimized k-space strategy, an optimized acquisition train length, or optimized imaging parameters.
    Type: Application
    Filed: March 11, 2016
    Publication date: February 15, 2018
    Inventors: Jinghua WANG, Zhong-lin LU, Nehal PARIKH, Lili HE
  • Publication number: 20170052123
    Abstract: Systems and methods are provided herein for the extraction, detection and measurement of MNPs in complex matrices in particular, the method includes mixing a solution including a predetermined organic substance with a matrix including the metal nanoparticles, the predetermined organic substance adapted to bind to the metal nanoparticles, to facilitate extraction by an organic solvent and to provide a distinct SERS signal, the mixing resulting in a suspension, adding a solution of a predetermined organic extraction solvent to the suspension, extracting and separating the metal nanoparticles; the metal nanoparticles, after extraction, functionalized by binding with the predetermined organic substance, and extracting and separating the metal nanoparticles; the metal nanoparticles, after extraction, functionalized by binding with the predetermined organic substance; and performing SERS imaging on the functionalized metal nanoparticles in order to detect metals nanoparticles.
    Type: Application
    Filed: August 17, 2016
    Publication date: February 23, 2017
    Inventors: Lili He, Baoshan Xing, Huiyuan Guo
  • Publication number: 20160356721
    Abstract: A bacterial detection platform integrating the sensitive SERS technique and the advanced mapping technique. Bacterial cells on the SERS substrate are detected using the mapping technique. The identification is based on the fingerprint of the bacterial SERS spectra. The quantification of the cells is based on the mapping technique. For different applications, silver or gold nanoparticles can be integrated onto a filter membrane for concentration and detection of bacterial cells in water or silver dendrites can be used as the SERS substrate. The SERS substrates are also modified with capturers and fixed in a vessel to concentrate cells from complex liquid matrices.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 8, 2016
    Applicant: University of Massachusetts
    Inventor: Lili He
  • Publication number: 20140350377
    Abstract: Disclosed is a hand-held, medical, multi-channel biological information acquisition mobile terminal system, comprising two signal sensing gloves RL with a cable end embedded therein, for use in acquiring a variety of biological signals comprising multi-channel interconnected ECG, heart sounds, finger blood volume pulse, and skin impedance etc., the signal sensing gloves RL also comprising a signal acquisition device S, a signal transmission device C connected to the signal acquisition device S, and a mobile terminal T connected wirelessly or with a wired connection. The system has the characteristics of low power consumption, small size, low cost and fewer control channels needed for multi-channel connection; and the system can achieve on-site acquisition of a variety of biological information and the mobile function of electronic health records.
    Type: Application
    Filed: September 10, 2012
    Publication date: November 27, 2014
    Inventors: Zhiwei Liang, Zhangjin Su, Lili He, Xiaoping Lai
  • Patent number: D884835
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: May 19, 2020
    Inventor: Lili He
  • Patent number: D911074
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: February 23, 2021
    Inventor: Lili He
  • Patent number: D921400
    Type: Grant
    Filed: February 1, 2021
    Date of Patent: June 8, 2021
    Inventor: Lili He