Abstract: A micro-magnetic invisible orthodontic appliance is provided. The micro-magnetic invisible orthodontic appliance includes a bottom brace (1), an outer periodontal brace (2) and an inner periodontal brace (3). The bottom brace (1), the outer periodontal brace (2) and the inner periodontal brace (3) together form a U-shaped brace. A tooth receiving groove is defined between the outer periodontal brace (2) and the inner periodontal brace (3). The bottom brace (1), the outer periodontal brace (2) and the inner periodontal brace (3) are made from one of a polymer composite material, biological ceramic, and an interpenetrating polymer network material, dispersed with permanent magnetic neodymium-iron-boron powder, by one-piece molding or three-dimensional printing.

Abstract: An efficient structure and methodology for container-based applications are provided for disaster recovery for data in a storage system using application consistency groups for replication from the storage system to a disaster recovery system. Application consistency groups can be generated containing applications, a disaster recovery plan, and a disaster recovery policy, where each application has a consistency level. The applications in an application consistency group can include stateless applications and stateful applications. The replication of an application consistency group from the system to a disaster recovery storage system can be controlled according to the disaster recovery policy, the disaster recovery plan, and the consistency levels of the application consistency group.

Abstract: A micro-magnetic integrated orthodontic bracket, a flexible magnetic patch and a preparation method thereof are provided. The micro-magnetic integrated orthodontic bracket includes a base body and an arch wire groove disposed on the base body. The arch wire groove is used for threading an arch wire. Under normal orthodontic treatment, the micro-magnetic integrated orthodontic bracket is normally disposed on a buccal side of a tooth, and its front side is normally arranged with the arch wire for force exertion to carry out the orthodontic treatment. And the micro-magnetic integrated orthodontic bracket serves as a carrier to bear the orthodontic treatment force generated by the arch wire.

Abstract: The present invention belongs to the medical field, and relates to novel ?-lactamase inhibitors, for the treatment of bacterial infections in combination with ?-lactam antibiotics, including infection caused by drug resistant organisms and especially multi-drug resistant organisms. The present invention includes compounds according to formula (I): or pharmaceutically acceptable salts thereof, wherein M and R are as defined herein.

Abstract: A multifunctional near-infrared orthodontic accelerator for inhibiting dental plaque formation is provided, including a bottom brace, an outer periodontal brace, an inner periodontal brace, a tooth groove disposed between the outer periodontal brace and the inner periodontal brace, and micro vibrators disposed on a side close to the tooth groove. The outer periodontal brace and the inner periodontal brace are respectively provided with a holding groove therein, which is communicated with openings facing towards the tooth groove. The holding grooves are provided with tooth cleaning bars, which are connected through universal joints and disposed linearly. The tooth cleaning bars are provided with cavities, which are provided with blue light germicidal lamps fitted to inner walls of the cavities. The outer periodontal brace and the inner periodontal brace are equipped with infrared laser lights, and outer peripheries of the tooth cleaning bars are equipped with bristle strips.

Abstract: Provided are conjugate molecules comprising a CD39 inhibitory portion capable of interfering interaction between CD39 and its substrate, and a TGF ? inhibitory portion capable of interfering interaction between TGF ? and its receptor, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same and the uses thereof.

Abstract: Provided are a dihydronaphthyridinone compound as shown in formula (I), which compound has a selective inhibitory effect on RIPK1, and a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof. In addition, provided are a pharmaceutical composition containing the compound, and the use thereof in the preparation of a drug for treating RIPK1-related diseases or conditions.

Abstract: A metal composite, a method of preparing the metal composite, a metal-resin composite, and a method of preparing the metal-resin composite are provided. The metal composite comprises: a metal substrate comprising a first layer formed on a surface of the metal substrate and an anodic oxidation layer formed on the first layer. The first layer comprises a first pore having an average diameter of about 10 nanometers to about 1 millimeter, and the metal composite comprises aluminum alloy or aluminum. The anodic oxidation layer comprises a second layer contacted with the first layer of the metal substrate and a third layer formed on an outer surface of the second layer, and the second layer comprises a second pore having an average diameter of about 10 nanometers to about 800 microns, and the third layer comprises a third pore having an average diameter of about 10 nanometers to about 800 microns.

Abstract: A metal composite, a method of preparing the metal composite, a metal-resin composite, and a method of preparing the metal-resin composite are provided. The metal composite comprises: a metal substrate comprising a first layer formed on a surface of the metal substrate and an anodic oxidation layer formed on the first layer. The first layer comprises a first pore having an average diameter of about 10 nanometers to about 1 millimeter, and the metal composite comprises aluminum alloy or aluminum. The anodic oxidation layer comprises a second layer contacted with the first layer of the metal substrate and a third layer formed on an outer surface of the second layer, and the second layer comprises a second pore having an average diameter of about 10 nanometers to about 800 microns, and the third layer comprises a third pore having an average diameter of about 10 nanometers to about 800 microns.