Abstract: A chromatography column design and a packing device, as well as a method for obtaining a column with a very compact and uniform bed are provided. The bed remains compact and uniform during operation of the column and during sanitization, storage and transportation of the column. The amount of hardware, particularly the hardware parts in contact with product, is minimized, especially with the implementation of an internal liner. With this internal liner, the packed bed can be separated from the column in intact form, or even prepared separately from, and outside of, the column.

Abstract: A chromatography column design and a packing device, as well as a method for obtaining a column with a very compact and uniform bed are provided. The bed remains compact and uniform during operation of the column and during sanitization, storage and transportation of the column. The amount of hardware, particularly the hardware parts in contact with product, is minimized, especially with the implementation of an internal liner. With this internal liner, the packed bed can be separated from the column in intact form, or even prepared separately from, and outside of, the column.

Abstract: A chromatography column design and a packing device, as well as a method for obtaining a column with a very compact and uniform bed are provided. The bed remains compact and uniform during operation of the column and during sanitization, storage and transportation of the column. The amount of hardware, particularly the hardware parts in contact with product, is minimized, especially with the implementation of an internal liner. With this internal liner, the packed bed can be separated from the column in intact form, or even prepared separately from, and outside of, the column.

Abstract: Novel features enhancing the operation of a diaphragm valve include a specialized diaphragm profile for enhanced securement of the diaphragm in the valve body, and a quick-connect feature joining the diaphragm to its actuator, in which the forward end of the actuator contains a sloping surface, an expanded tip, and a shoulder, while the diaphragm contains a truncated bore with a complementary profile. The valve can be modular in construction to permit mounting of the valve to an instrument panel in close proximity to other valves or components to provide the ability to select among interconnected fluid flow paths.