Abstract: This disclosure relates to nanoparticles comprising a surface molecule that binds or blocks PD-L1. In certain embodiments, the disclosure relates to methods of using peptides or nanoparticles disclosed herein for the treatment of cancer. In certain embodiments, the disclosure relates to methods of using nanoparticles disclosed herein for therapeutic and diagnostic applications.

Abstract: Methods and apparatus to generate vehicle warnings are disclosed. An example apparatus includes a sensor to detect a vehicle, where the sensor is associated with an observer of the vehicle, an object tracker to determine a motion of the vehicle, an accident estimator to calculate a likelihood of a collision of the vehicle based on the determined motion, and a transceiver to transmit a message to the vehicle upon the likelihood of the collision exceeding a threshold, where the message includes information pertaining to the collision.

Abstract: This disclosure relates to targeted protease compositions and uses related thereto. In certain embodiments, the disclosure relates to nanoparticles wherein a targeting molecule is linked to the nanoparticle and wherein a catalytic domain of a protease is linked to the nanoparticle. In certain embodiments, the targeting molecule and the catalytic domain are within a single polypeptide sequence. In certain embodiments, the targeting molecule binds a molecule more highly expressed on cancer cells then non-cancerous cells, and the nanoparticles disclosed herein are used for the treatment of cancer by further attaching an anti-cancer agent to the nanoparticle or incorporating an anticancer agent within the nanoparticle.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed for anomaly detection and recovery. An apparatus to isolate a first controller in an autonomous vehicle includes a first controller to control a reference signal of the autonomous vehicle via a communication bus, a second controller to control the reference signal of the autonomous vehicle when the first controller is compromised, and a message neutralizer to neutralize messages transmitted by the first controller when the first controller is compromised, the neutralized messages to cause the first controller to become isolated from the communication bus.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed that provide an apparatus to analyze vehicle perspectives, the apparatus comprising a profile generator to generate a first profile of an environment based on a profile template and first data generated by a first vehicle; a data analyzer to: determine a difference between the first profile and a second profile obtained from a first one of one or more nodes in the environment; and in response to a trigger event, update the first profile based on the difference; and a vehicle control system to: in response to the trigger event, update a first perspective of the environment based on one or more of second data from the first one of the one or more nodes or the updated first profile; update a path plan for the first vehicle based on the updated first perspective; and execute the updated path plan.

Abstract: In an automated method for providing driving assistance, an electronic control unit (ECU) of a first driving assistance system of a first vehicle receives local object information from at least one sensing component of the first driving assistance system. The first driving assistance system automatically detects external objects outside of the first vehicle, based on the local object information received from the at least one sensing component. The first driving assistance system also receives a reported object list (ROL) from a second vehicle, wherein the ROL describes objects detected by a second driving assistance system in the second vehicle. The first driving assistance system also affects operation of the first vehicle, based on (a) the external objects detected by the first vehicle and (b) the ROL from the second vehicle. Other embodiments are described and claimed.

Abstract: There is disclosed in one example a computing apparatus, including: a hardware platform; a network interface to communicatively couple to a bus lacking native support for authentication; and an anomaly detection engine to operate on the hardware platform and configured to: receive a first data stream across a first time; symbolize and approximate the first data stream, including computing a first window sum; receive a second data stream across a second time substantially equal in length to the first time, the second data stream including data across the plurality of dimensions from the first data stream; symbolize and approximate the second data stream, including computing a second window sum; compute a difference between the first window sum and the second window sum; determine that difference exceeds a threshold and that the correlation across the plurality of dimensions is broken; and flag a potential anomaly.

Abstract: This disclosure relates to nanoparticles carrying nucleic acid cassettes for expressing RNA. In certain embodiments, the disclosure relates to improved methods for targeted delivery and expression of siRNAs in vivo using DNA-based siRNA-expressing nanocassettes and receptor-targeted nanoparticles. In certain embodiments, the disclosure relates to methods of targeted delivery of survivin siRNA expressing nanocassettes which enhance sensitivity of human cancer cells to anticancer agents.

Abstract: This disclosure relates to polymer coatings with desirable anti-fouling properties. In certain embodiments, polymers are coated on particles which allow for conjugation with targeting moieties. In certain embodiments, the particles are nanoparticles with targeting moieties that bind with tumor associated antigens.

Abstract: This disclosure relates to targeted protease compositions and uses related thereto. In certain embodiments, the disclosure relates to nanoparticles wherein a targeting molecule is linked to the nanoparticle and wherein a catalytic domain of a protease is linked to the nanoparticle. In certain embodiments, the targeting molecule and the catalytic domain are within a single polypeptide sequence. In certain embodiments, the targeting molecule binds a molecule more highly expressed on cancer cells then non-cancerous cells, and the nanoparticles disclosed herein are used for the treatment of cancer by further attaching an anti-cancer agent to the nanoparticle or incorporating an anticancer agent within the nanoparticle.

Abstract: A method comprising transmitting a request, by a mobile device, indicating one or more content items; determining a location for the mobile device, by a processor; establishing a connection with a transmission medium, based at least in part on the indicated one or more content items, if the indicated one or more content items is not on the mobile device, wherein the transmission medium includes a digital radio tower, a long range radio tower and a wireless access point; and activating the indicated one or more content items, if the indicated one or more content items is on the mobile device.

Abstract: A data storage device may comprise storage media comprising a plurality of sectors, and a controller configured to selectively read and write data thereto. The controller may be further configured to tag a sector as a bad sector to be relocated after a first failed read and to untag the tagged sector after a successful write attempt after the first failed read. After a second failed read from the sector subsequent to the successful write, the controller may tag the untagged sector as a bad sector to be relocated and adjust a recurring bad sector counter for that sector. On a subsequent write request, based at least in part on the bad sector counter and a threshold, the controller may determine whether to relocate data stored at a physical location on the data storage device corresponding to the sector to a spare location on the data storage device.

Abstract: A nanostructure and methods of synthesizing same. In one embodiment, the nanostructure includes a magnetic iron oxide nanoparticle, a hydrophobic protection structure including at least an amphiphilic copolymer, wherein the hydrophobic protection structure encapsulates the magnetic iron oxide nanoparticle, and at least one amino-terminal fragment (ATF) peptide or epidermal growth factor receptor (EGFR) antibody conjugated to the amphiphilic copolymer.

Abstract: This disclosure relates to nanoparticles carrying nucleic acid cassettes for expressing RNA. In certain embodiments, the disclosure relates to improved methods for targeted delivery and expression of siRNAs in vivo using DNA-based siRNA-expressing nanocassettes and receptor-targeted nanoparticles. In certain embodiments, the disclosure relates to methods of targeted delivery of survivin siRNA expressing nanocassettes which enhance sensitivity of human cancer cells to anticancer agents.

Abstract: A method comprising transmitting a request, by a mobile device, indicating one or more content items; determining a location for the mobile device, by a processor; establishing a connection with a transmission medium, based at least in part on the indicated one or more content items, if the indicated one or more content items is not on the mobile device, wherein the transmission medium includes a digital radio tower, a long range radio tower and a wireless access point; and activating the indicated one or more content items, if the indicated one or more content items is on the mobile device.

Abstract: Techniques for ordered and duplicate-free delivery of wireless data frames are provided. A source address, a destination address, and a message sequence number are acquired from a wireless data frame. The message sequence number is compared against a last-received message sequence number, and a last-delivered message sequence number. The destination address is also compared to a current address. In response to the compares, a decision is made to forward the wireless data frame to the destination address, discard the wireless frame as a duplicate wireless data frame, queue the wireless data frame, or release the wireless data frame to a next protocol layer.

Abstract: This disclosure relates to polymer coated particles targeting cancer cells and methods related thereto. In certain embodiments, the disclosure relates to nanoparticles coated with amphiphilic polymers conjugated with molecules useful for targeting tumors, monitoring the location of the nanoparticles administered to a subject by MRI, and viewing the presence of the nanoparticles during optical image-guided surgery.

Abstract: A nanostructure and methods of synthesizing same. In one embodiment, the nanostructure includes a nanospecies, a hydrophobic protection structure including at least one compound selected from a capping ligand, an amphiphilic copolymer, and combinations thereof, wherein the hydrophobic protection structure encapsulates the nanospecies, and at least one histidine-tagged peptide or protein conjugated to the hydrophobic protection structure, wherein the at least one histidine-tagged peptide or protein has at least one binding site.

Abstract: An embodiment of the present invention provides an apparatus, comprising a network interface (NIC) card operable in communication with a mobile platform to monitor network traffic and perform filtering to enable decreased system resource use in said mobile platform when in an Always On Always Connected (AOAC) state.

Abstract: A method for operating a communication station in a communicating environment includes: (a) monitoring the environment to ascertain whether the station is receiving an unintended sensed signal not intended for the station from at least one signal source; (b) if the station has not received a predetermined number of unintended sensed signals during a predetermined time interval, operating the station in an omni-directional mode; and (c) if the station has received a predetermined number of sensed signals during the predetermined time interval, saving an indication of a reception direction from which arrived each unintended sensed signal; and operating the station in a directional mode. While in the directional mode, the station is sensitive to receiving signals arriving from a sensing direction other than from a reception direction, and the station transmits signals toward the sensing direction.