Abstract: First audio data associated with a first portion of a voice query (e.g., an incomplete voice query) may be received (e.g., by a device or a server). A first transcript may be determined by a speech recognition engine and based on the first audio data. A plurality of predicted queries may be determined by applying a prediction process to the first transcript. A response for each of the plurality of predicted queries may be determined by processing the plurality of the predicted queries. Second audio data associated with a second portion of the voice query (e.g., a complete voice query) may be received. A second transcript may be determined by the speech recognition engine and based on the second audio data. Based on comparing the second transcript to one of the plurality of predicted queries, a response for the voice query may be returned.

Abstract: Provided are a compound as a PD-L1 inhibitor, a preparation method therefor, and use thereof. Further provided is use of the compound or a pharmaceutical composition thereof in the preparation of a medicine, wherein the medicine is used for preventing and treating a PD-L1-related disease.

Abstract: The present invention discloses a chitin regenerative hydrogel and a preparation method and application thereof, which belong to the technical field of energy materials. The preparation method of the chitin regenerative hydrogel comprises the following steps: 1, performing heating dissolution and cooling molding on chitin and ionic liquid to obtain chitin-ionic liquid gel; and S2, soaking the chitin-ionic liquid gel into alkaline solution to obtain the chitin regenerative hydrogel. The chitin-ionic liquid gel and the chitin regenerative hydrogel that are prepared in the present invention have good restoring capacity and thixotropy capacity.

Abstract: Described herein are compositions comprising (a) methyl 3 -((methyl sulfonyl)amino)-2-(((4-phenylcyclohexyl)oxy)methyl)piperidine- 1 -carboxylate or a salt thereof; and (b) an agent for reducing metabolism of (a) and uses thereof.

Abstract: The present invention provides a method for producing a virus and a harvesting solution composition. The method includes culturing cells, wherein the cells have been inoculated with viruses or have been transfected with viral packaging elements; and contacting the cultured cells with a harvesting solution composition to harvest the viruses by one-step, wherein the harvesting solution composition comprises a trypsin, a pH buffer and optionally a nuclease, and the pH of the harvesting solution composition is greater than 7.5 and no more than 10.5. The virus production method of the present invention has advantages of simple operation, easy scale-up, stable yield and so on, and the yield is unexpectedly and significantly improved compared to the prior art, and it can ensure the integrity of the viral particles without damaging the biological activity of the viruses. Therefore, it is very suitable for large-scale production of viruses.

Abstract: Disclosed are a whole-cell tumor vaccine based on the principle of extracellular traps and a method of making the same, where a CpG ODN network similar to the extracellular trap in structure is formed on the tumor cell surface. The tumor cells are coated with a histone and CpG ODN to form the CpG ODN-coated tumor cells, which are inactivated to produce the whole-cell tumor vaccine. The vaccine of the invention, after injected to tumor model mice, can induce the occurrence of effective immune response to achieve the effective treatment for tumors.

Abstract: The present invention relates to an injection-production relationship optimization method based on heterogeneous flow field characterization. The method comprises the steps of: first, calculating a density of a flow field by adopting a method of converting a linear density into a dot density; then, calculating an intensity of the flow field by adopting an analytic hierarchy process; and performing flow field characterization by utilizing mathematical methods such as PCA dimensionality reduction and clustering and calculating a product of flow line densities and intensities of flow fields in different regions of the flow field, and performing optimization for a goal of minimizing a variance of the product in combination of an genetic algorithm to solve the optimum injection-production quantity as an optimum solution (the optimum injection-production quantity) that enables the flow field to be displaced in a balanced manner.

Abstract: Disclosed are a bacteriologically-modified whole-cell tumor vaccine and a method of making the same. The method includes: lysing bacteria at logarithmic growth phase to obtain a bacterial lysate; mixing the bacterial lysate with an excessive amino compound solution to aminate the bacterial lysate in the presence of EDC; mixing the aminated bacterial lysate with the tumor cells for a certain period of time to produce bacteriologically-modified tumor cells; and inactivating the bacteriologically-modified tumor cells to produce the bacteriologically-modified whole-cell tumor vaccine. The bacteriologically-modified whole-cell tumor vaccine has been demonstrated to have desirable therapeutic effect in tumor model mice.

Abstract: The present invention relates to a preparation method for an amide compound and an application thereof in the field of medicine. Specifically, provided by the present invention is an amide small molecule compound which is an inhibitor of Zeste gene enhancer homolog 2 (EZH2) and which may be used to prevent and/or treat EZH2-mediated related diseases, comprising tumors, myeloproliferative diseases or autoimmune diseases.

Abstract: A method for removing oxide materials from a crack of a metallic workpiece comprises: infiltrating an alkali solution into the crack in a pressurized atmosphere or an ultrasonic environment; applying an energy to the crack to react the oxide materials with the alkali solution and form a resultant material; and rinsing the resultant material with an acid solution to remove the resultant material from the crack. The method is easier to penetrate into the inside of the cracks, in particular suitable for cleaning narrow and deep cracks.

Abstract: Provided are a preparation method for amide compounds and use thereof in medical field. Specifically, provided are small molecule amide compounds. Such compounds are inhibitors of enhancer homolog 2 (EZH2) of Zeste gene, and can be used for preventing and/or treating related diseases mediated by EZH2, including tumors, myeloproliferative diseases or autoimmune diseases.

Abstract: An interactive method and device for an e-commerce application program are provided, which belong to the technical field of mobile terminal. The method includes: receiving an interactive virtual item sent from a seller account in an interactive channel of the e-commerce application program, wherein the interactive channel is a collection of groups configured to realize instant communications between the seller account and at least one user account, and the interactive channel corresponds to a product category in the e-commerce application program; determining the at least one user account in the interactive channel; and sending the interactive virtual item to the at least one user account in the interactive channel.

Abstract: The present disclosure relates to a parallel proxy model based machine learning method for oil reservoir production. With the proposed method, multiple optimized candidate solutions can be obtained within an iteration, and then a matrix laboratory (e.g., MATLAB) is used to call numerical simulation software Eclipse in parallel to conduct actual evaluation on the candidate solutions simultaneously, so that optimization time of complex problems can be greatly reduced. With the method of the present disclosure, the efficiency of solving an oilfield production optimization problem can be speeded up to a greater extent than in the art, and the final optimization effect can be improved. Moreover, the method of the present disclosure may further be used for well pattern optimization, history matching, and so on, apart from adjusting schedules of the producers and injectors in the oilfield.

Abstract: A method includes masking at least one hole of an article with a paste, wherein the hole opens onto a surface of the article, applying a coating to the surface of the article, and removing the paste including contacting the paste with water, leaving at least one open hole in the surface of the coated article. The paste includes about 40-80 wt % of a filler material, about 0.5-20 wt % of an inorganic binder, about 0.5-15 wt % of a polyhydroxy compound and about 5-25 wt % of water. The filler material includes a first material which includes alkali metal doped alumina, zirconium oxide, titanium oxide, silicon dioxide, or a combination thereof and a second material which includes a silicate. A weight ratio between the first and second materials is in a range of about 1-10.

Abstract: A method of recondensing boil off gas includes receiving liquefied natural gas from a storage tank and increasing the pressure of the received liquefied natural gas to produce increased pressure liquefied natural gas. The method further includes receiving boil off gas from the storage tank at a gas inlet of an ejector, and receiving the increased pressure liquefied natural gas at a liquefied gas inlet of the ejector. The pressure of the increased pressure liquefied gas is used as a motive force to eject combined liquefied natural gas and boil off gas at a pressure greater than that of the boil off gas received at the gas inlet of the ejector. The method additionally includes increasing the pressure of the fluid ejected from the ejector to produce increased pressure ejected fluid.

Abstract: Disclosed are a class of ?-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The ?-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.

Abstract: A method for removing oxide materials from a crack of a metallic workpiece comprises: infiltrating an alkali solution into the crack in a pressurized atmosphere or an ultrasonic environment; applying an energy to the crack to react the oxide materials with the alkali solution and form a resultant material; and rinsing the resultant material with an acid solution to remove the resultant material from the crack. The method is easier to penetrate into the inside of the cracks, in particular suitable for cleaning narrow and deep cracks.

Abstract: Embodiments of the present disclosure provide a terminal verification method, a terminal device and a computer readable storage medium. The method includes: reading machine verification parameters of a target terminal, determining that the target terminal is a fake in response to determining that the machine verification parameters of the target terminal satisfy a first condition, a second condition and a third condition, and displaying on a user interface of the target terminal that the target terminal is a fake.

Abstract: Embodiments of the present disclosure provide a terminal verification method, a terminal device and a computer readable storage medium. The method includes: reading machine verification parameters of a target terminal, determining that a system of the target terminal is modified in response to determining that the machine verification parameters of the target terminal satisfy a first condition, a second condition and a third condition, and displaying on a user interface of the target terminal that, the system of the target terminal is modified.

Abstract: Embodiments of the present disclosure provide a terminal verification method, a terminal device and a computer readable storage medium. The method includes: reading machine verification parameters of a target terminal, determining that the target terminal is incompletely configured in response to determining that the machine verification parameters of the target terminal satisfy a first condition and a second condition, and displaying on a user interface of the target terminal that, the target terminal is incompletely configured. The machine verification parameters of the target terminal include N terminal configuration parameters. The first condition includes abnormally reading the GPU manufacturer parameter and the GPU renderer parameter. The second condition includes normally reading a first group of terminal configuration parameters of the machine verification parameters of the target terminal. The first group of terminal configuration parameters includes (N?2) terminal configuration parameters.