Abstract: Disclosed is a nitrogen-containing heterocyclic compound, pharmaceutical compositions thereof and use thereof. The present disclosure provides a nitrogen-containing heterocyclic compound represented by formula I, a pharmaceutically acceptable salt thereof, a solvate thereof, a solvate of pharmaceutically acceptable salt thereof, a crystal thereof, a stereoisomer thereof, a tautomer thereof or an isotopically labeled compound thereof. The nitrogen-containing heterocyclic compound represented by formula I is expected to treat and/or prevent various PI3K-meditated diseases.

Abstract: Disclosed in the present invention are a compound having a BRD4 inhibitory activity, a preparation method therefor and the use thereof. The structure of the compound having the BRD4 inhibitory activity of the present invention is as shown in formula I, and the definition of each substituent is as described in the description and claims. The compound of the present invention has a high bromodomain protein inhibitory activity, in particular a BRD4-targeting inhibitory activity, and can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

Abstract: The present application discloses a dispatching and control cloud data processing method, device and system. The method includes the following operations: pilot node device acquires a global scheduling task, decomposes the global scheduling task to obtain scheduling tasks, issues the scheduling tasks to collaborative node device, acquires data collection ranges and data processing rules of the collaborative node devices, and delivers them to the collaborative node devices; the collaborative node devices receive and execute the scheduling tasks issued by the pilot node device; receives the data collection ranges and the data processing rules issued by the pilot node device, acquires, based on the scheduling tasks, collected data in the data collection ranges, processes the acquired collected data according to the data processing rules to obtain the processed data, uploads the processed data to the pilot node device; the pilot node device receives the processed data uploaded by the collaborative node devices.

Abstract: The present disclosure provides a method of monitoring, evaluating and early-warning pollution for key pollution sources in an industrial park. The method comprises: a multi-index on-line early-warning monitoring method for pollution from key pollution sources, a hierarchical pollution risk evaluating method, and a pollution early-warning grade evaluating method, which are in line with the environmental management solution that pollution prevention is the priority in an industrial park in China.

Abstract: Provided are an audio/video processing method and apparatus, a device, and a storage medium. The method comprises: displaying text data corresponding to an audio/video to be edited, wherein the text data has a mapping relation with an audio/video timestamp of said audio/video; displaying said audio/video according to a time axis track; in response to a preset operation triggered for target text data in the text data, determining an audio/video timestamp corresponding to the target text data as a target audio/video timestamp; and processing, on the basis of the preset operation, an audio/video clip corresponding to the target audio/video timestamp in said audio/video.

Abstract: The present invention discloses a extra thick hot rolled H section steel and a production method therefor. The extra thick hot rolled H section steel contains, by mass, the following chemical components: 0.04-0.11% of C, 0.10-0.40% of Si, 0.40-1.00% of Mn, 0.40-1.00% of Cr, 0.10-0.40% of Cu, 0.020-0.060% of Nb, 0.040-0.100% of V, 0.010-0.025% of Ti, 0.010-0.030% of Al, 0.0060-0.0120% of N, not more than 0.015% of P, not more than 0.005% of S, not more than 0.0060% of O, and the balance Fe and trace residual elements, wherein 0.090%?Nb+V+Ti?0.170%, 6.5?(V+Ti)/N?10.5, and 0.30%?CEV?0.48%. The extra thick hot rolled H section steel has a flange thickness of 90 mm-150 mm, has excellent comprehensive mechanical properties, and can well meet the needs for heavy supporting structural parts of high-rise buildings, large squares, bridge structures, etc.

Abstract: A reshaping method for metal product includes acquiring position data information of a workpiece; converting the position data information into coordinate information, and fitting the coordinate information to obtain a surface contour curve of the workpiece; comparing the surface contour curve with a standard contour curve to generate a comparison result; obtaining reshaping information of the workpiece based on the comparison result; and controlling the reshaping system to reshape the workpiece. The disclosure acquires position data information of the workpiece by measuring, converts the position data information into coordinate information, fits the coordinate information to obtain the surface contour curve of the workpiece, compares the surface contour curve with the standard contour curve to obtain deformation situation, and reshapes the workpiece according to the reshaping information based on the deformation situation, which improves efficiency of workpiece reshaping and reducing labor costs.

Abstract: A button battery including a housing assembly, an electrode assembly, a first tab and a second tab. The housing assembly includes a first conductive portion and a second conductive portion insulated from each other. The electrode assembly includes first electrode plates and second electrode plates of opposite polarities. The first tab includes a first connecting portion and a first extension portion. The first connecting portion is connected to each first electrode plate, and the first extension portion assumes a continuously curved shape. One of the first conductive portion or the second conductive portion is connected to the first electrode plate. When the button battery is dropped, the electrode assembly inside the housing assembly is displaced relative to the housing assembly.

Abstract: A pulse detonation combustion system includes: an inlet pipe; an intake cone disposed in the inlet pipe, having an end provided with a pneumatic valve, and including an atomizing air transfer tube, a fuel transfer tube, and a conical swirl nozzle connected to the atomizing air transfer tube and the fuel transfer tube; an atomizing air intake tube connected with the atomizing air transfer tube; a fuel supply tube connected with the fuel transfer tube; a pulse detonation combustion chamber located downstream of and communicated to the inlet pipe, and provided with a spark plug mounting seat for mounting a spark plug; a gas energy distribution adjustment device located downstream of and communicated to the pulse detonation combustion chamber; and a transition section located downstream of and communicated to the gas energy distribution adjustment device.

Abstract: A gas turbine power generation device includes: an inlet pipe (1), a compressor (2), an air storage compartment (3), a compressor rotor (4), a compressor gear shift (6), a compressor exhaust pipeline (8), a combustion chamber intake pipeline (10), a combustion chamber intake cone (11), a combustion chamber pneumatic valve (14), a spark plug (19), a combustion chamber (21), a Tesla turbine (22), a gas collection compartment (27), an outlet pipe (28), a turbine rotor (30), a generator gear shift (32) and a generator (33).

Abstract: An electrode plate including an electrode plate body, a tab, a first adhesive layer, and a second adhesive layer. The tab includes a connecting portion connected to an extending portion. The connecting portion overlaps with and is connected to the electrode plate body. The extending portion protrudes from the connecting portion out of one side of the electrode plate body along a first direction. The first adhesive layer is disposed on the extending portion. The second adhesive layer includes a first part bonded to a surface of the electrode plate body and covering the connecting portion; and a second part formed by extending the first part from a side near the first adhesive layer along the first direction and bonded to the first adhesive layer. In a second direction perpendicular to the first direction, a width of the second part is less than a width of the first part.

Abstract: A pulse detonation combustion system includes: an inlet pipe; an intake cone disposed in the inlet pipe, having an end provided with a pneumatic valve, and including an atomizing air transfer tube, a fuel transfer tube, and a conical swirl nozzle connected to the atomizing air transfer tube and the fuel transfer tube; an atomizing air intake tube connected with the atomizing air transfer tube; a fuel supply tube connected with the fuel transfer tube; a pulse detonation combustion chamber located downstream of and communicated to the inlet pipe, and provided with a spark plug mounting seat for mounting a spark plug; a gas energy distribution adjustment device located downstream of and communicated to the pulse detonation combustion chamber; and a transition section located downstream of and communicated to the gas energy distribution adjustment device.

Abstract: A gas turbine power generation device includes: an inlet pipe (1), a compressor (2), an air storage compartment (3), a compressor rotor (4), a compressor gear shift (6), a compressor exhaust pipeline (8), a combustion chamber intake pipeline (10), a combustion chamber intake cone (11), a combustion chamber pneumatic valve (14), a spark plug (19), a combustion chamber (21), a Tesla turbine (22), a gas collection compartment (27), an outlet pipe (28), a turbine rotor (30), a generator gear shift (32) and a generator (33).

Abstract: A dry low NOX staged combustion system includes a fuel nozzle and a combustion compartment. The fuel nozzle includes a purge gas tube, a diffusion combustion fuel tube, an isolation gas tube, a premixed combustion fuel tube, a premixed combustion air tube. The purge gas tube is configured to feed a purge gas. The diffusion combustion fuel tube is fitted over the purge gas tube, and having an end provided with a diffusion combustion fuel swirler. The isolation gas tube is fitted over the diffusion combustion fuel tube. The premixed combustion fuel tube is fitted over the isolation gas tube. The premixed combustion air tube is fitted over the premixed combustion fuel tube. The combustion compartment is located downstream of the fuel nozzle.

Abstract: The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical composition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

Abstract: Embodiments provide methods and systems for modeling the flow of fluid in variable physical and geological environments using dynamically determined Navier-Stokes equations (NSE), such as Darcy Flow and Poiseuille flow.

Abstract: A system for processing purchase of commodities from a vending machine comprises a transaction detecting module, a control module, a transaction verification module, a display module, and a commodity dispensing module. In allowing one type of payment for commodities, the system prevents other payment types being used. The transaction module detects a transaction request and the control module obtains commodity information and a payment method that is user-selected, other payment methods then being forbidden. The transaction verification module verifies whether a payment is made under the selected payment method. If the payment is successful, the commodity dispensing module controls the vending machine to dispense commodity, if not, the display module controls a touch screen to output transaction failure information. A transaction method of the vending machine is also provided.

Abstract: A tool bit holder for connecting a rotary tool to a rotary tool driver. The tool bit holder including a body having a driver end configured to connect to a rotary tool driver and a tool end, a tool retainer bore, and a tool retainer movably received within the tool retainer bore and movable between an engaged position and a retracted position. The tool bit holder further includes an actuator sleeve, a sleeve spring for urging the actuator sleeve towards a first position, a plunger, and a plunger spring urging the plunger towards a loading position. A tool bit received in a tool receiving cavity pushes the plunger to a loaded position, and in the loading position the plunger extends over the tool retainer bore to engage the tool retainer and urge the tool retainer towards the retracted position.

Abstract: A tool bit holder for connecting a rotary tool to a rotary tool driver. The tool bit holder including a body having a driver end configured to connect to a rotary tool driver and a tool end, a tool retainer bore, and a tool retainer movably received within the tool retainer bore and movable between an engaged position and a retracted position. The tool bit holder further includes an actuator sleeve, a sleeve spring for urging the actuator sleeve towards a first position, a plunger, and a plunger spring urging the plunger towards a loading position. A tool bit received in a tool receiving cavity pushes the plunger to a loaded position, and in the loading position the plunger extends over the tool retainer bore to engage the tool retainer and urge the tool retainer towards the retracted position.

Abstract: A split-screen display method and apparatus, and an electronic device thereof. A horizontal slide signal along a touchscreen or a vertical slide signal along the touchscreen entered by using the touchscreen is obtained; a current display area of the touchscreen is divided, according to the horizontal slide signal, into at least two display windows arranged up and down, or a current display area of the touchscreen is divided, according to the vertical slide signal, into at least two display windows arranged side by side, thereby implementing that multiple application programs are simultaneously displayed on a screen up and down or side by side, and a user does not need to frequently switch between programs, which facilitates user operations.