Abstract: Devices and methods for determining a position of a hole drilled in tissue in endoscopic surgical procedures include a drill guide configured to guide a drill bit to drill a hole in tissue of internal anatomy of a patient, the drill guide comprising: a shaft configured to receive the drill bit, wherein a distal end of the shaft is configured to interface with the tissue; and at least one fiducial marker positioned proximate the distal end of the shaft and configured to provide position information for the hole in an endoscopic image captured by an endoscopic imaging device.

Abstract: The present invention pertains to a novel fusion protein and/or fusion peptide, preferably for use in the separation from and/or detection in an environment of one or more target polymers or plastics, e.g., one or more target polymer fragments and/or particles or target plastic fragments and/or particles, preferably wherein the one or more target polymer particles or target plastic particles are microplastics; a method of preparing such novel fusion protein and/or fusion peptide, a system and kit comprising the novel fusion protein and/or fusion peptide and a (polymer or non-polymer) carrier or carrier system, a use of the novel fusion protein and/or fusion peptide or of a system and kit as mentioned in the separation from and/or detection in an environment of one or more target polymers or plastics, e.g.

Abstract: A mobility augmentation system assists a user's movement by determining a corresponding electrical stimulation for the movement. A wearable stimulation array includes sensors, electrodes, an electrode multiplexer, and a controller that executes the mobility augmentation system. The sensors measure movement data, and the mobility augmentation system applies a movement model to the measured movement data. The model can determine different electrical actuation instructions depending on the movement stimulated. For example, to stimulate a knee flexion, the movement model output enables a first set of the electrodes to operate as cathodes and a second set of electrodes to operate as anodes. To stimulate a knee extension, the first set of electrodes can be enabled to operate as anodes and a third set of electrodes as cathodes. The user can provide feedback of the applied stimulation, which the system can use to retrain the model and optimize the stimulation to the user.

Abstract: A method of operation of a navigation system comprising: receiving multiple frames, including a first frame and a second frame, of images; detecting a traffic sign from the images between the first frame and the second frame based on a sign recognition model; extracting a first image from the first frame and a second image from the second frame; matching the traffic sign is the same in the first image and the second image based on a similarity model; generating a sign location of the traffic sign with an inertial measurement unit reading based on the first image and the second image; and generating a global coordinate for the sign location for displaying on a navigation map.

Abstract: A probe comprising a biomarker-triggered moiety, a near infrared (NIR) fluorophore reporter, a self-immolative linker and a self-immobilizing moiety for visualization of senescent cells and methods of use thereof.

Abstract: A mobility augmentation system monitors a user's motor intent data and augments the user's mobility based on the monitored motor intent data. A machine-learned model is trained to identify an intended movement based on the monitored motor intent data. The machine-learned model may be trained based on generalized or specific motor intent data (e.g., user-specific motor intent data). A machine-learned model initially trained on generalized motor intent data may be re-trained on user-specific motor intent data such that the machine-learned model is optimized to the movements of the user. The system uses the machine-learned model to identify a difference between the user's monitored movement and target movement signals. Based on the identified difference, the system determines actuation signals to augment the user's movement. The actuation signals determined can be an adjustment to a currently applied actuation such that the system optimizes the actuation strategy during application.

Abstract: A large field-of-view adaptive optics retinal imaging system and method with common optical path beam scanning, the system comprises: a light source module (1), an adaptive optics module (2), a beam scanning module (3), a defocus compensation module (4), a sight beacon module (6), a pupil monitoring module (7), a detection module (8), a control module (9) and an output module (10). The beam scanning module is configured in different scanning modes for carrying out different scanning imaging functions including a large field-of-view imaging function, a small field-of-view high-resolution imaging function and a large field-of-view high-resolution imaging function. The system is simple in structure, and the common optical path structure can obtain three types of retinal imaging images, which meets the requirements of different application scenarios and improves the application range of retinal imaging.

Abstract: Disclosed are bispecific synthetic aptamers and methods of their use for the detection of cell surface receptors and the treatment of cancer.

Abstract: Glasses containing silicon dioxide (SiO2) and/or boron oxide (B2O3) as glass formers and having a refractive index nd of greater than or equal to 1.7, as measured at 587.56 nm, and a density of less than or equal to 4.5 g/cm3, as measured at 25° C., are provided. Optionally, the glasses may be characterized by a low optical dispersion, a high transmittance in the visible and near-ultraviolet (near-UV) range of the electromagnetic spectrum, and/or good glass forming ability.

Abstract: Disclosed herein are solid forms of a compound useful for modulating Cot. The disclosure also relates to pharmaceutical compositions containing one or more of the solid forms disclosed herein, as well as methods of using the solid forms in the treatment of conditions mediated by Cot. The disclosure also relates to methods for obtaining such solid forms.

Abstract: Glasses containing silicon dioxide (SiO2) and/or boron oxide (B2O3) as glass formers and having a refractive index nd of greater than or equal to 1.80, as measured at 587.56 nm, a density of less than or equal to 5.5 g/cm3, as measured at 25° C., and a high transmittance to, particularly to blue light, are provided. Optionally, the glasses may be characterized by a high transmittance in the visible and near-ultraviolet (near-UV) range of the electromagnetic spectrum and/or good glass forming ability.

Abstract: A semiconductor device fabrication method includes providing a processing wafer. The processing wafer has core and staircase structure (SS) regions, and includes a bottom conductor layer, conductor/dielectric tier(s) over the bottom conductor layer, and a channel hole (CH) in the core region and extending approximately vertically through the conductor/dielectric tier(s). The CH includes a channel layer and a memory film surrounding the channel layer. A protrusion portion of the channel layer and a protrusion portion of the memory film extend into the bottom conductor layer. The method further includes patterning the bottom conductor layer to remove a portion of the bottom conductor layer in the core region to expose the protrusion portion of the memory film, performing etching to remove the protrusion portion of the memory film to expose the protrusion portion of the channel layer, performing impurity implantation, and performing laser activation.

Abstract: Disclosed herein are systems and methods for intelligent generation and display of insights using information in a data repository. For example, disclosed herein are methods for generating and displaying insights using initial data from a data repository, and intelligently/automatically proposing, generating, and displaying further insights using previously-generated insights.

Abstract: A lacosamide pharmaceutical composition as well as a preparation method and application thereof are provided. According to the lacosamide pharmaceutical composition, lacosamide or a pharmaceutically acceptable salt thereof can be dissolved out at the same time, wherein the dissolution rate of the lacosamide pharmaceutical composition is not more than 40% within 1 hour, the dissolution rate of the lacosamide pharmaceutical composition is 20-70% within 6 hours, and the dissolution rate of the lacosamide pharmaceutical composition is not less than 65% within 24 hours. The lacosamide pharmaceutical composition has good slow release performance, the tablet size can be rapidly expanded in the in-vitro dissolution process, the expanded lacosamide pharmaceutical composition has good rigidity and elasticity and has a remarkable retention effect in the stomach, and the cumulative release rate within 24 hours can reach 80% or above.

Abstract: A mobility augmentation system assists a user's movement by determining a corresponding electrical stimulation for the movement. A wearable stimulation array includes sensors, electrodes, an electrode multiplexer, and a controller that executes the mobility augmentation system. The sensors measure movement data, and the mobility augmentation system applies a movement model to the measured movement data. The model can determine different electrical actuation instructions depending on the movement stimulated. For example, to stimulate a knee flexion, the movement model output enables a first set of the electrodes to operate as cathodes and a second set of electrodes to operate as anodes. To stimulate a knee extension, the first set of electrodes can be enabled to operate as anodes and a third set of electrodes as cathodes. The user can provide feedback of the applied stimulation, which the system can use to retrain the model and optimize the stimulation to the user.

Abstract: Glasses containing silicon dioxide (SiO2) and/or boron oxide (B2O3) as glass formers and having a refractive index nd of greater than or equal to 1.7, as measured at 587.56 nm, and a density of less than or equal to 4.5 g/cm3, as measured at 25° C., are provided. Optionally, the glasses may be characterized by a low optical dispersion, a high transmittance in the visible and near-ultraviolet (near-UV) range of the electromagnetic spectrum, and/or good glass forming ability.

Abstract: The present disclosure relates to compositions and methods for restoring enamel, e.g., on tooth surfaces.

Abstract: The invention relates to a dentin collagen fibril demineralizing material, and a preparation method and application thereof. The invention relates to a conjugate of water-soluble chitosan and an aminocarboxylic acid metal chelating agent used for dental demineralization, preferably dentin demineralization. The invention also discloses a dentin collagen fibril demineralizing material and a preparation method and application thereof, wherein the material is prepared from 0.5-1 part by mass of water-soluble chitosan, 10-30 parts by mass of EDTA, and 0.8-1.5 parts by mass of cross-linking agent. The invention relates to a dental demineralization composition comprising a conjugate and a material of the invention. The conjugate, material and composition can be used for dentin demineralization treatment before dental bonding and restoration.

Abstract: An advanced manufactured interpenetrating polymer network (AM-IPN) comprising: a primary polymer network; a secondary polymer network, wherein the secondary polymer network is bonded to the primary polymer network via one or more crosslinks, wherein one or more of the primary polymer network, the secondary polymer network and the one or more crosslinks are printed using a synthetic bioink is disclosed. Methods of making and using are also disclosed.

Abstract: Provided are an anti-CLDN6 antibody or an antigen-binding fragment thereof; a nucleic acid molecule encoding same; an immunoconjugate, a bispecific molecule, a chimeric antigen receptor and a pharmaceutical composition containing same; and the use thereof for preventing and/or treating tumors.