Patents by Inventor Linda Castle
Linda Castle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140287419Abstract: Compositions and methods comprising polynucleotides and polypeptides having dicamba decarboxylase activity are provided. Further provided are nucleic acid constructs, host cells, plants, plant cells, explants, seeds and grain having the dicamba decarboxylase sequences. Various methods of employing the dicamba decarboxylase sequences are provided. Such methods include, for example, methods for decarboxylating an auxin-analog, method for producing an auxin-analog tolerant plant, plant cell, explant or seed and methods of controlling weeds in a field containing a crop employing the plants and/or seeds disclosed herein. Methods are also provided to identify additional dicamba decarboxylase variants.Type: ApplicationFiled: March 14, 2014Publication date: September 25, 2014Inventors: Eric Althoff, Yih-En Andrew Ban, Linda A. Castle, Daniela Grabs, Jian Lu, Phillip A. Patten, Yumin Tao, Alexandre Zanghellini
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Publication number: 20140289906Abstract: Compositions and methods comprising polynucleotides and polypeptides having dicamba decarboxylase activity are provided. Further provided are nucleic acid constructs, host cells, plants, plant cells, explants, seeds and grain having the dicamba decarboxylase sequences. Various methods of employing the dicamba decarboxylase sequences are provided. Such methods include, for example, methods for decarboxylating an auxin-analog, method for producing an auxin-analog tolerant plant, plant cell, explant or seed and methods of controlling weeds in a field containing a crop employing the plants and/or seeds disclosed herein. Methods are also provided to identify additional dicamba decarboxylase variants.Type: ApplicationFiled: March 14, 2014Publication date: September 25, 2014Inventors: Eric Althoff, Yih-En Andrew Ban, Linda A. Castle, Daniela Grabs, Jian Lu, Phillip A. Patten, Yumin Tao, Alexandre Zanghellini
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Publication number: 20140249027Abstract: Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.Type: ApplicationFiled: March 7, 2014Publication date: September 4, 2014Applicants: PIONEER HI BRED INTERNATIONAL INC, E I DU PONT DE NEMOURS AND COMPANYInventors: LINDA A. CASTLE, Yong Hong Chen, Nicholas Duck, Lorraine J. Giver, Rebecca Gorton, Cristina Ivy, Roger Kemble, Bill F. McCutchen, Jeremy Minshull, Phillip A. Patten, Daniel L. Siehl
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Publication number: 20130340114Abstract: Compositions and methods comprising polynucleotides and polypeptides having ALS activity and tolerance to at least one ALS inhibitor are provided. In specific embodiments, the sequence has an increased preference for 2-ketobutyrate, when compared to an appropriate control, such as for example, HRA, and/or a preference for 2-ketobutyrate similar to a native ALS. Further provided are nucleic acid constructs, plants, plant cells, explants, seeds and grain having the ALS inhibitor tolerant sequences. Various methods of employing the ALS inhibitor tolerant sequences are provided. Such methods include methods for producing an ALS inhibitor tolerant plant, plant cell, explant or seed and methods of controlling weeds in a field containing a crop employing the plants and/or seeds disclosed herein.Type: ApplicationFiled: June 12, 2013Publication date: December 19, 2013Inventors: HENRIK ALBERT, JOHN LAWRENCE ANDREASSI, II, SEAN BERTAIN, LINDA A. CASTLE, STEVEN GUTTERIDGE, DANIEL L. SIEHL, KAY WALTER
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Publication number: 20130102765Abstract: Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.Type: ApplicationFiled: June 5, 2012Publication date: April 25, 2013Applicants: Verdia Inc., E.I. du Pont de Nemours and Company, Pioneer Hi-Bred International, Inc.Inventors: Linda A. Castle, Dan Siehl, Lorraine Giver, Jeremy Minshull, Christina Ivy, Yong Hong Chen, Phillip A. Patten, Rebecca Gorton, Nicholas B. Duck, Billy Fred McCutchen, Roger Kemble
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Patent number: 8377681Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.Type: GrantFiled: December 2, 2011Date of Patent: February 19, 2013Assignee: Codexis Mayflower Holdings, LLCInventors: Stephen DelCardayre, Matthew B. Tobin, Willem P. C. Stemmer, Jon E. Ness, Jeremy S. Minshull, Phillip A. Patten, Venkiteswatan Mani Subramanian, Linda A. Castle, Claus M. Krebber, Steven H. Bass, Ying-Xin Zhang, Anthony R. Cox, Gjalt W. Huisman, Ling Yuan, Joseph A. Affholter
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Publication number: 20120288914Abstract: The presently disclosed subject matter provides compositions and methods for evaluating the potential of candidate polypeptides to associate with glyphosate with a higher binding affinity, higher binding specificity, or both or to have N-acetyltransferase activity with a higher catalytic rate when compared to a native glyphosate acetyltransferase (GLYAT) polypeptide through the provision and comparison of three-dimensional molecular structures of the candidate polypeptides and the GLYAT polypeptides provided herein. The methods further provide for identification of polypeptides with these advantageous properties using the three-dimensional molecular structures of GLYAT polypeptides.Type: ApplicationFiled: July 7, 2010Publication date: November 15, 2012Applicant: PIONEER HI BRED INTERNATIONAL INC.Inventors: Daniel Siehl, Robert J. Keenan, Zhenglin Hou, Linda A. Castle
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Publication number: 20120255070Abstract: Compositions and methods are provided for the efficient transformation of a dicot plant. More particularly, compositions and methods of the present invention find use in agriculture for Agrobacterium-mediated transformation of a dicotyledonous plant. The compositions include cultivation media comprising high concentrations of sucrose and glucose. The cultivation media find use in methods directed to Agrobacterium-mediated transformation of a dicot plant with a gene of interest. In this manner, any gene of interest can be introduced into a dicot plant with high transformation efficiency and reduced tissue necrosis.Type: ApplicationFiled: April 3, 2012Publication date: October 4, 2012Applicant: Pioneer Hi Bred International Inc.Inventors: Hyeon-Je Cho, Linda A. Castle, Theodore M. Klein, Tai Minh, York Moy
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Publication number: 20120252681Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.Type: ApplicationFiled: December 2, 2011Publication date: October 4, 2012Applicant: CODEXIS MAYFLOWER HOLDINGS, LLCInventors: Stephen del Cardayre, Matthew Tobin, Willem P.C. Stemmer, Jon E. Ness, Jeremy Minshull, Phillip Patten, Venkiteswaran Subramanian, Linda A. Castle, Claus M. Krebber, Steven H. Bass, Ying-Xin Zhang, Tony Cox, Gjalt Huisman, Ling Yuan, Joseph A. Affholter
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Publication number: 20120245339Abstract: Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.Type: ApplicationFiled: June 5, 2012Publication date: September 27, 2012Applicants: Verdia Inc., E.I. du Pont de Nemours and Company, Pioneer Hi-Bred International, Inc.Inventors: Linda A. Castle, Dan Siehl, Lorraine Giver, Jeremy Minshull, Christina Ivy, Yong Hong Chen, Phillip A. Patten, Rebecca Gorton, Nicholas B. Duck, Billy Fred McCutchen, Roger Kemble
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Patent number: 8222489Abstract: Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.Type: GrantFiled: November 23, 2010Date of Patent: July 17, 2012Assignees: Verdia Inc., Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and CompanyInventors: Linda A. Castle, Dan Siehl, Lorraine Giver, Jeremy Minshull, Cristina Ivy, Yong Hong Chen, Phillip A. Patten, Rebecca Gorton, Nicholas B. Duck
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Publication number: 20120122686Abstract: Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.Type: ApplicationFiled: November 18, 2011Publication date: May 17, 2012Applicants: Verdia, Inc., E.I. Du Pont De Nemours, Pioneer Hi-Bred International, Inc.Inventors: Linda A. Castle, Dan Siehl, Lorraine Giver, Jeremy Minshull, Christina Ivy, Yong Hong Chen, Phillip A. Patten, Rebecca Gorton, Nicholas B. Duck, Billy Fred McCutchen, Roger Kemble
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Publication number: 20120042414Abstract: Compositions and methods comprising promoters from the 4-hydroxyphenylpyruvate dioxygenase (HPPD) gene and active variants and fragments thereof, as well as chimeric promoters employing regulatory regions of the HPPD promoters are provided. Further provided are expression cassettes and plants comprising the various promoters disclosed herein operably linked to a polynucleotide of interest. Methods employing the various promoters described herein to modulate the expression of polynucleotides of interest are further provided.Type: ApplicationFiled: August 12, 2011Publication date: February 16, 2012Applicant: Pioneer Hi-Bred International, Inc.Inventors: Henrik Albert, Linda A. Castle, Jian Lu, Yumin Tao
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Publication number: 20120042412Abstract: Chimeric polynucleotides comprising a nucleotide sequence encoding a chloroplast transit peptide operably linked to a heterologous polynucleotide of interest are provided, wherein the chloroplast transit peptide comprises an amino acid sequence having the chloroplast transit peptide sequence as set forth in SEQ ID NO:1 or a biologically active variant or fragment thereof or wherein the chloroplast transit peptide comprises the sequence set forth in SEQ ID NO: 58 or an active variant or fragment thereof. Chimeric polypeptides encoding the same, as well as, cells, plant cells, plants and seeds are further provided which comprise the chimeric polynucleotides. Compositions further include HPPD polypeptides and polynucleotides encoding the same as set forth in SEQ ID NOS: 57 and 60 or active variants and fragments thereof. Such sequences comprise the chloroplast transit peptide as set forth in SEQ ID NO: 58 or an active variants or fragments thereof.Type: ApplicationFiled: August 12, 2011Publication date: February 16, 2012Applicant: Pioneer Hi-Bred International, Inc.Inventors: Henrik Albert, Linda A. Castle, Matthew Heckert, Jian Lu, Daniel L. Siehl, Yumin Tao
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Publication number: 20120042413Abstract: Compositions and methods comprising polynucleotides and polypeptides having 4-hydroxyphenylpyruvate dioxygenase (HPPD) activity and having insensitivity to an HPPD inhibitor are provided. Further provided are nucleic acid constructs, plants, plant cells, explants, seeds and grain having the HPPD sequences. Various methods of employing the HPPD sequences are provided. Such methods include, for example, methods for producing an HPPD inhibitor tolerant plant, plant cell, explant or seed and methods of controlling weeds in a field containing a crop employing the plants and/or seeds disclosed herein. Methods are also provided to identify additional HPPD variants. Further provided are various methods and compositions that allow the various HPPD polypeptides and variant and fragments thereof to be expressed in a chloroplast or transported to a chloroplast.Type: ApplicationFiled: August 12, 2011Publication date: February 16, 2012Applicant: Pioneer Hi-Bred International, Inc.Inventors: Henrik Albert, Ericka R. Bermudez, Linda A. Castle, Yuxia Dong, Matthew J. Heckert, Jingtong Hou, Zhenglin Hou, Jian Lu, Daniel L. Siehl, Yumin Tao
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Patent number: 8088972Abstract: Proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are polynucleotides capable of encoding these proteins, compositions that include one or more of these proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these compounds, diversification methods involving the compounds, and methods of using the compounds. Some of the methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.Type: GrantFiled: April 1, 2009Date of Patent: January 3, 2012Assignees: Verdia, Inc., Pioneer Hi-Bred International, Inc., E.I. DuPont de NemoursInventors: Linda A. Castle, Dan Siehl, Lorraine Giver, Jeremy Minshull, Cristina Ivy, Yong Hong Chen, Phillip A. Patten, Rebecca Gorton, Nicholas B. Duck, Billy Fred McCutchen, Roger Kemble
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Patent number: 8076138Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.Type: GrantFiled: October 15, 2009Date of Patent: December 13, 2011Assignee: Codexis Mayflower Holdings, LLCInventors: Stephen DelCardayre, Matthew B. Tobin, Willem P. C. Stemmer, Jon E. Ness, Jeremy S. Minshull, Phillip A. Patten, Venkiteswatan Mani Subramanian, Linda A. Castle, Claus M. Krebber, Steven H. Bass, Ying-Xin Zhang, Anthony R. Cox, Gjalt W. Huisman, Ling Yuan, Joseph A. Affholter
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Patent number: 8044261Abstract: Proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are polynucleotides capable of encoding these proteins, compositions that include one or more of these proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these compounds, diversification methods involving the compounds, and methods of using the compounds. Some of the methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.Type: GrantFiled: August 3, 2009Date of Patent: October 25, 2011Assignees: E. I. du Pont de Nemours, Verdia Inc., Pioneer Hi-Bred International, Inc.Inventors: Linda A. Castle, Dan Siehl, Lorraine Giver, Jeremy Minshull, Cristina Ivy, Yong Hong Chen, Phillip A. Patten, Nicholas B. Duck, Rebecca Gorton, Billy Fred McCutchen, Roger Kemble
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Publication number: 20110257023Abstract: The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.Type: ApplicationFiled: June 24, 2011Publication date: October 20, 2011Applicant: CODEXIS MAYFLOWER HOLDINGS, LLCInventors: Claes Gustafsson, Sridhar Govindarajan, Robin A. Emig, Richard John Fox, Ajoy K. Roy, Jeremy S. Minshull, S. Christopher Davis, Anthony R. Cox, Phillip A. Patten, Linda A. Castle, Daniel L. Siehl, Rebecca Lynne Gorton, Teddy Chen
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Patent number: 8021857Abstract: Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.Type: GrantFiled: August 3, 2009Date of Patent: September 20, 2011Assignees: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours, Verdia Inc.Inventors: Linda A. Castle, Dan Siehl, Lorraine Giver, Jeremy Minshull, Cristina Ivy, Yong Hong Chen, Phillip A. Patten, Nicholas B. Duck, Rebecca Gorton, Billy Fred McCutchen, Roger Kemble