Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy.

Abstract: A utility line snow or ice removal device mounts to a support structure, such as a utility pole cross-arm. The device includes a moving support arranged to support a utility line, such that a combined weight of the utility line and any snow or ice on the utility line is borne by the moving support. A release arrangement is configured to maintain the moving support in a first position when the combined weight is below a release threshold. When the combined weight exceeds the release threshold, the release arrangement is arranged to release the moving support from the first position to allow the utility line to move under the combined weight from the supported position, creating a sudden movement of the utility line that shakes snow/ice build-up from the line. The device also includes a resetting arrangement configured to return the moving support to the first position when snow/ice has been removed.

Abstract: A utility line snow or ice removal device mounts to a support structure, such as a utility pole cross-arm. The device includes a moving support arranged to support a utility line, such that a combined weight of the utility line and any snow or ice on the utility line is borne by the moving support. A release arrangement is configured to maintain the moving support in a first position when the combined weight is below a release threshold. When the combined weight exceeds the release threshold, the release arrangement is arranged to release the moving support from the first position to allow the utility line to move under the combined weight from the supported position, creating a sudden movement of the utility line that shakes snow/ice build-up from the line. The device also includes a resetting arrangement configured to return the moving support to the first position when snow/ice has been removed.

Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy.

Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy.

Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy.

Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy.

Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy.

Abstract: A microfilm recorder system includes a frame, a film supply canister mountable on the frame for holding a roll of microfilm, a film take-up canister insertable on and removable from the frame for receiving the film, and a film transport assembly for moving the film from the film supply canister to the film take-up canister. The film take-up canister includes a reel on which film is wound when the reel is rotated, and a driven mechanism which, when driven, causes the reel to rotate. A driving mechanism is mounted on the frame to automatically engage and drive the driven mechanism when the film take-up canister is inserted on the frame.