Patents by Inventor Lindsey Ann Needham

Lindsey Ann Needham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENZYME AND RECEPTOR MODULATION
    Publication number: 20210361772
    Abstract: Covalent conjugation of an alpha amino acid ester to a modulator of the activity of a target intracellular enzyme or receptor, wherein the ester group of the conjugate is hydrolysable by one or more intracellular carboxylesterase enzymes to the corresponding acid, leads to accumulation of the carboxylic acid hydrolysis product in the cell and enables improved or more prolonged enzyme or receptor modulation relative to the unconjugated modulator.
    Type: Application
    Filed: May 21, 2021
    Publication date: November 25, 2021
    Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    Inventors: Alan Hornsby DAVIDSON, Alan Hastings DRUMMOND, Lindsey Ann NEEDHAM
  • DETECTION OF HISTONE MODIFICATION IN CELL-FREE NUCLEOSOMES
    Publication number: 20190353653
    Abstract: This invention relates to the diagnosis of disease conditions, such as cancer and autoimmune disease, by the analysis of cell-free nucleosomes in samples from individuals. Methods of the invention may include contacting cell-free nucleosomes from a biological fluid sample obtained from the individual with an antibody that binds specifically with a modified histone protein. Binding of the antibody to the nucleosomes is indicative that the individual has the disease condition.
    Type: Application
    Filed: July 26, 2019
    Publication date: November 21, 2019
    Inventors: Lindsay Jane BAWDEN, Elisabeth Ann Bone, Alan Hastings Drummond, Lindsey Ann Needham
  • Detection of histone modification in cell-free nucleosomes
    Patent number: 10408831
    Abstract: This invention relates to the diagnosis of disease conditions, such as cancer and autoimmune disease, by the analysis of cell-free nucleosomes in samples from individuals. Methods of the invention may include contacting cell-free nucleosomes from a biological fluid sample obtained from the individual with an antibody that binds specifically with a modified histone protein. Binding of the antibody to the nucleosomes is indicative that the individual has the disease condition.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: September 10, 2019
    Assignee: SINGAPORE VOLITION PTE. LIMITED
    Inventors: Lindsay Jane Bawden, Elisabeth Ann Bone, Alan Hastings Drummond, Lindsey Ann Needham
  • ENZYME AND RECEPTOR MODULATION
    Publication number: 20190231887
    Abstract: Covalent conjugation of an alpha amino acid ester to a modulator of the activity of a target intracellular enzyme or receptor, wherein the ester group of the conjugate is hydrolysable by one or more intracellular carboxylesterase enzymes to the corresponding acid, leads to accumulation of the carboxylic acid hydrolysis product in the cell and enables improved or more prolonged enzyme or receptor modulation relative to the unconjugated modulator.
    Type: Application
    Filed: January 24, 2019
    Publication date: August 1, 2019
    Inventors: Alan Hornsby DAVIDSON, Alan Hastings DRUMMOND, Lindsey Ann NEEDHAM
  • ENZYME AND RECEPTOR MODULATION
    Publication number: 20180000952
    Abstract: Covalent conjugation of an alpha amino acid ester to a modulator of the activity of a target intracellular enzyme or receptor, wherein the ester group of the conjugate is hydrolysable by one or more intracellular carboxylesterase enzymes to the corresponding acid, leads to accumulation of the carboxylic acid hydrolysis product in the cell and enables improved or more prolonged enzyme or receptor modulation relative to the unconjugated modulator.
    Type: Application
    Filed: July 14, 2017
    Publication date: January 4, 2018
    Inventors: Alan Hornsby Davidson, Alan Hastings Drummond, Lindsey Ann Needham
  • DETECTION OF HISTONE MODIFICATION IN CELL-FREE NUCLEOSOMES
    Publication number: 20150330996
    Abstract: This invention relates to the diagnosis of disease conditions, such as cancer and autoimmune disease, by the analysis of cell-free nucleosomes in samples from individuals. Methods of the invention may include contacting cell-free nucleosomes from a biological fluid sample obtained from the individual with an antibody that binds specifically with a modified histone protein. Binding of the antibody to the nucleosomes is indicative that the individual has the disease condition.
    Type: Application
    Filed: August 3, 2015
    Publication date: November 19, 2015
    Inventors: Lindsay Jane BAWDEN, Elizabeth Ann BONE, Alan Hastings DRUMMOND, Lindsey Ann NEEDHAM
  • Detection of histone modification in cell-free nucleosomes
    Patent number: 9128086
    Abstract: This invention relates to the diagnosis of disease conditions, such as cancer and autoimmune disease, by the analysis of cell-free nucleosomes in samples from individuals. Methods of the invention may include contacting cell-free nucleosomes from a biological fluid sample obtained from the individual with an antibody that binds specifically with a modified histone protein. Binding of the antibody to the nucleosomes is indicative that the individual has the disease condition.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: September 8, 2015
    Assignee: SINGAPORE VOLITION PTE. LIMITED
    Inventors: Lindsay Jane Bawden, Elizabeth Ann Bone, Alan Hastings Drummond, Lindsey Ann Needham
  • ENZYME AND RECEPTOR MODULATION
    Publication number: 20150126534
    Abstract: Covalent conjugation of an alpha amino acid ester to a modulator of the activity of a target intracellular enzyme or receptor, wherein the ester group of the conjugate is hydrolysable by one or more intracellular carboxylesterase enzymes to the corresponding acid, leads to accumulation of the carboxylic acid hydrolysis product in the cell and enables improved or more prolonged enzyme or receptor modulation relative to the unconjugated modulator.
    Type: Application
    Filed: October 7, 2014
    Publication date: May 7, 2015
    Inventors: Alan Hornsby Davidson, Alan Hastings Drummond, Lindsey Ann Needham
  • Enzyme and Receptor Modulation
    Publication number: 20090215800
    Abstract: Covalent conjugation of an alpha amino acid ester to a modulator of the activity of a target intracellular enzyme or receptor, wherein the ester group of the conjugate is hydrolysable by one or more intracellular carboxylesterase enzymes to the corresponding acid, leads to accumulation of the carboxylic acid hydrolysis product in the cell and enables improved or more prolonged enzyme or receptor modulation relative to the unconjugated modulator.
    Type: Application
    Filed: May 4, 2006
    Publication date: August 27, 2009
    Applicant: CHROMA THERAPEUTICS LTD
    Inventors: Alan Hornsby Davidson, Alan Hastings Drummond, Lindsey Ann Needham