Abstract: Disclosed is a wearable article continuous in a longitudinal direction and a transverse direction comprising a front elastic belt region, a back elastic belt region, a crotch region, a waist opening and two leg openings; the crotch region extending longitudinally between the front elastic belt region and the back elastic belt region; the front elastic belt region having an area of A1, the crotch region having an area of A2, the back elastic belt region having an area of A3, the front elastic belt region having a front placement distance L8, and the back elastic belt region having a back placement distance L9 according to the measurements herein; wherein the total of A1, A2 and A3 is from about 1250 cm2 to about 1400 cm2, and having a relationship of A3>A1>A2; and wherein the ratio of L8 to L9 is no more than about 0.8.

Abstract: The method is for identifying a signal and its image signal input to the heterodyne frequency sweep system. Comparing to a traditional heterodyne frequency sweep technology, a mixing module with a positive and negative sign filters (PNS filters) is introduced, and the detection and identification module is added, and the typical low-pass filter in the input module is removed. According to the timing order sequence of the signal output from the intermediate frequency (IF) filter and PNS filters, a signal and its image signal can be identified. The bandwidth of the heterodyne frequency sweep system is not limited by the cut-off frequency of the low-pass filter (LPF) of the traditional heterodyne frequency sweep system.

Abstract: Disclosed are compounds of Formula I, or a salt thereof: where A, B, D, X, R1, R2 and R8 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.

Abstract: Disclosed is a wearable article comprising a main body and a ring-like elastic belt comprising a front belt and a back belt. At least some of the elastic bodies may be arranged in an array, the array defined as meeting: a) one array is formed by 2-10 elastic bodies; b) each elastic body within one array is disposed in an inner-interval between each elastic body of 2-4 mm; and c) one specific array disposed in an extra-interval between at least one neighboring elastic bodies outside the specific array of greater than the inner-interval. Further, the front belt may comprise at least 5 arrays.

Abstract: The present disclosure relates to wearable articles having an elastic belt having arrays of elastic bodies.

Abstract: A wearable article wherein least some of the elastic bodies may be arranged in at least 2 sets of a concentrated array defined as meeting: a) one concentrated array is formed by 2-4 elastic bodies; b) each elastic body within one concentrated array is disposed in an inner-interval between each elastic body of 2-4 mm; and c) one specific concentrated array disposed in an extra-interval between at least one neighboring elastic body outside the specific concentrated array of less than 8 mm. The entirety of the length of the belt side edge of the front belt may be seamed with a certain length of the belt side edge of the back belt to define a seam length LS. The front and back belts may each divided into 4 zones wherein at least 2 concentrated arrays are disposed on the front proximal tummy zone or the back distal tummy zone.

Abstract: A wearable article includes a front and back elastic belts, a crotch region, a waist opening, and leg openings. Each elastic belt is a laminate having an inner sheet, an outer sheet, and an elastic member. Elastic adhesive bonding continuously bonds the elastic member for at least about 10 mm in the direction of stretch adjacent the side edges of the belts. A discrete patterned adhesive bonding is applied to at least one of the inner and outer sheets to intermittently bond the inner and outer sheets. The discrete patterned adhesive bonding extends substantially along the transverse direction between the elastic adhesive bonding, and substantially along the longitudinal direction between the distal and proximal edges of the elastic belts. The same adhesive agent provides the elastic adhesive and discrete patterned adhesive bonding. Heat bonds form side seams, and the remainder of the laminate is free of heat bonds.

Abstract: An article with the entirety of the length of the belt side edge of the front belt seamed with a certain length of the belt side edge of the back belt to define a seam length LS. The front and back belts may each be divided into 4 zones extending in the transverse direction and defined by its location from the distal edge to the proximal edge relative to the percentage of the seam length LS where: 0-25% is the waist zone, 25-50% is the distal tummy zone, 50-85% is the proximal tummy zone, and 85-100% is the leg zone. The tensile stress of the front leg zone may be no more than 50% of the tensile stress of the front proximal tummy zone, and the tensile stress of the back leg zone may be no more than 100% of the tensile stress of the back proximal tummy zone.

Abstract: The present invention relates to novel Bicyclic Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, X, Y, Z, R1 R5, R6, and R7 are as defined herein. The present invention also relates to compositions comprising at least one Bicyclic Heterocycle Compound, and methods of using the Bicyclic Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: An ultrasonic method for quantifying the nonlinear shear wave elasticity of a medium, the method comprising the following steps: A1.—collecting a temporal succession of shear wave elasticity data from the medium, A2.—applying, to the medium, a deformation that successively changes according to a predetermined sequence of deformations, during the collection of the shear waves, A3.—observing the actual evolution of deformation, and B.—quantifying the nonlinear elasticity of the medium depending on the temporal succession of data and the evolution of deformation.

Abstract: The disclosure relates to absorbent articles having at least a first belt which comprises a first, second and third zone. The at least first belt provides improved fit in the low motion zone of a wearer while being able to adapt easily to the motion of the wearer outside the low motion zone.

Abstract: The present invention is related to a signal spectrum analysis technology based on linear frequency modulation transformation (LFM) and fast digital pulse compression, which comprises two parts: a circuit for linear frequency modulation signal and an algorithm for fast digital pulse compression. Wherein, in the circuit the modulated chirp signals are obtained by the input signals mixing with the LO chirp signal and then filtered by the band-pass filter the intermediate frequency (IF) chirp signals are produced. The IF signals are composed of the chirp signals with the same frequency band and the chirp rate, but different initial times. Due to the IF chirp signals being orthogonal to each other, the spectrum of the input signals is extracted by the initial time and the orthogonal accumulation. The full spectrum of the input signal is obtained by changing the start position of the sampling data sets along the time axis.

Abstract: Disclosed is a pant type absorbent article having a back elastic belt comprising a waist guard portion extending towards the crotch region from a closed base line towards an open edge, wherein the waist guard portion is formed by a first inner waist fold extending from a second inner waist fold, the second inner waist fold extending from the inner sheet, and a first elastic member bonded between the first inner waist fold and the second inner waist fold, wherein the waist guard portion is partially bonded to the remainder of the elastic belt from which the first and second inner waist folds extend to define a pocket.

Abstract: Disclosed is a pant type absorbent article having a waist guard portion on the back elastic belt, wherein the waist guard portion has a specific location in view of the location from the distal edge to the proximal edge relative to the percentage of the seam length LS, the waist guard portion comprising a waist guard elastic portion having a longitudinal dimension of no greater than about 40 mm, wherein the remainder of the elastic belt superposing the waist guard elastic portion is defined a correlated portion, wherein the tensile stress of the waist guard elastic portion is higher than that of the correlated portion.

Abstract: The disclosure relates to absorbent articles having a front belt and a rear belt, each comprising a central zone and first and second peripheral zones, the zones extending substantially in transverse direction of the absorbent article. The at least first belt provides improved fit in the low motion zone of a wearer while being able to adapt easily to the motion of the wearer outside the low motion zone.

Abstract: The disclosure relates to absorbent articles having a front belt and a rear belt, each comprising a central zone and first and second peripheral zones, the zones extending substantially in transverse direction of the absorbent article. The at least first belt provides improved fit in the low motion zone of a wearer while being able to adapt easily to the motion of the wearer outside the low motion zone.

Abstract: Disclosed are compounds of Formula I, or a salt thereof: where A, B, D, X, R1, R2 and R8 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.

Abstract: The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: The present disclosure relates to front and back waist belt assemblies for absorbent articles. In some configurations, an absorbent article may include an absorbent chassis. First and second belts may be connected with opposing end regions of the chassis. At least one of the first belt and the second belt may comprise: an elastic material positioned between and connected with a first substrate and a second substrate. A panel layer extending longitudinally from a first lateral edge to a second lateral edge may be connected with at least one of the first substrate and the second substrate. The panel layer and/or the first and/or second substrate of the first and/or second belts may include features that differ along a width and/or length of the belts. Such features may include belt tensioning, rugosities, bonding patterns, and/or aperture arrangements.

Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.