Patents by Inventor Lingxun Duan

Lingxun Duan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENERATING IPS CELLS BY PROTEIN TRANSDUCTION OF RECOMBINANT POTENCY-DETERMINING FACTORS
    Publication number: 20120142094
    Abstract: The present invention relates generally to compositions and methods for reprogramming a primate somatic cell to a higher potency level. Specifically, the invention includes compositions which comprise a recombinant polypeptide that is a potency-determining factor and methods of reprogramming a primate somatic cell to a higher potency level under conditions that allow sufficient amount of the polypeptide delivered into the primate somatic cell.
    Type: Application
    Filed: April 1, 2010
    Publication date: June 7, 2012
    Applicant: LD Biopharma, Inc.
    Inventor: Lingxun Duan
  • Methods and vectors for generating antibodies in avian species and uses therefor
    Patent number: 6951742
    Abstract: The present invention relates to processes for producing polyclonal and monoclonal antibodies to an antigen in an avian species, preferably in a chicken, using polynucleotide vaccination. The present invention also relates to processes for determining the proteomics profile of a set of pre-selected DNA sequences isolated from a bio-sample, preferably the proteomics profile of a human cDNA library. The present invention additionally relates to processes for identifying physiologically distinguishable markers associated with a physiologically abnormal bio-sample. The present invention further relates to antibody arrays, integrated databases for identification of genes and proteins, multi-functional gene expression vectors, and methods of producing and using such antibody arrays, integrated databases and multi-functional gene expression vectors.
    Type: Grant
    Filed: May 16, 2000
    Date of Patent: October 4, 2005
    Assignee: GenWay Biotech, Inc.
    Inventor: Lingxun Duan
  • Methods and vectors for generating antibodies in avian species and uses therefor
    Publication number: 20050208628
    Abstract: The present invention relates to processes for producing polyclonal and monoclonal antibodies to an antigen in an avian species, preferably in a chicken, using polynucleotide vaccination. The present invention also relates to processes for determining the proteomics profile of a set of pre-selected DNA sequences isolated from a bio-sample, preferably the proteomics profile of a human cDNA library. The present invention additionally relates to processes for identifying physiologically distinguishable markers associated with a physiologically abnormal bio-sample. The present invention further relates to antibody arrays, integrated databases for identification of genes and proteins, multi-functional gene expression vectors, and methods of producing and using such antibody arrays, integrated databases and multi-functional gene expression vectors.
    Type: Application
    Filed: March 30, 2005
    Publication date: September 22, 2005
    Inventor: Lingxun Duan
  • Production of recombinant monellin using methylotrophic yeast expression system
    Patent number: 6780615
    Abstract: The present invention relates to a single-chain monellin-like protein which is stable and which is at least 100-fold sweet as compared to sucrose on the weight basis. The present invention also relates to a nucleic acid encoding said monellin-like protein. Preferably, the nucleic acid further comprises a promoter and a signal sequence for directing expression and secretion of the encoded monellin-like protein in the methylothrophic yeast Pichia pastoris. The present invention further relates to a recombinant Pichia pastoris cell containing the nucleic acid encoding the monellin-like protein, a process for producing the monellin-like protein from the recombinant Pichia pastoris and product of the process.
    Type: Grant
    Filed: June 26, 2001
    Date of Patent: August 24, 2004
    Assignee: Genway Biotech Inc.
    Inventor: Lingxun Duan
  • Ribozyme-mediated gene replacement
    Patent number: 6077705
    Abstract: Methods of gene therapy, particular ribozyme-mediated gene replacement methods, are disclosed. Method of treating patients suffering from a disease associated with expression of an abnormal form of a gene, such as alpha-1 antitrypsin mutations, are disclosed. The methods comprise the steps of administering to such a patient a nucleic acid construct encoding a ribozyme and a nucleic acid construct comprising a ribozyme resistant gene encoding a wild type form of the gene product. Recombinant vectors and pharmaceutical compositions for practicing the methods are disclosed.
    Type: Grant
    Filed: May 14, 1997
    Date of Patent: June 20, 2000
    Assignee: Thomas Jefferson University
    Inventors: Lingxun Duan, Mark A. Zern, Roger J. Pomerantz