Patents by Inventor Lingyun XIAO
Lingyun XIAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11926592Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.Type: GrantFiled: September 2, 2022Date of Patent: March 12, 2024Assignee: Amgen Inc.Inventors: Henry Morrison, Sheng Cui, Kyle Quasdorf, Evelyn Yanez, Bin Peter Quan, Ron C. Kelly, Sebastien Caille, Lingyun Xiao, David Pearson, Jaclyn Raeburn, Alisa Golightly
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Publication number: 20230108971Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.Type: ApplicationFiled: September 2, 2022Publication date: April 6, 2023Inventors: Henry Morrison, Sheng Cui, Kyle Quasdorf, Evelyn Yanez, Bin Peter Quan, Ron C. Kelly, Sebastien Caille, Lingyun Xiao, David Pearson, Jaclyn Raeburn, Alisa Golightly, Bradley Morgan, Matthew Peterson, Alex Eberlin, Alexander Oblezov
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Patent number: 11465969Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.Type: GrantFiled: August 16, 2019Date of Patent: October 11, 2022Assignees: CYTOKINETICS, INC., AMGEN INC.Inventors: Henry Morrison, Sheng Cui, Kyle Quasdorf, Evelyn Yanez, Bin Peter Quan, Ron C. Kelly, Sebastien Caille, Lingyun Xiao, David Pearson, Jaclyn Raeburn, Ailsa Golightly, Bradley Morgan, Matthew Peterson, Alex Eberlin, Alexander Oblezov
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Publication number: 20210221771Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.Type: ApplicationFiled: August 16, 2019Publication date: July 22, 2021Inventors: Henry Morrison, Sheng Cui, Kyle Quasdorf, Evelyn Yanez, Bin Peter Quan, Ron C. Kelly, Sebastien Caille, Lingyun Xiao, David Pearson, Jaclyn Raeburn, Ailsa Golightly, Bradley Morgan, Matthew Peterson, Alex Eberlin, Alexander Oblezov
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Patent number: 11026988Abstract: The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising Lycii fructus polysaccharide, Polygonati rhizoma polysaccharide, Caryophylli flos oil and Cinnamomi cortex oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4+ and CD8+ cells in lymphocytes of the tumor stroma, increases body immune function, recovers normal immune surveillance function, decreases the expression rate of VEGF and TGF-? 1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor.Type: GrantFiled: August 8, 2018Date of Patent: June 8, 2021Assignee: INFINITUS (CHINA) COMPANY LTD.Inventors: Fangli Ma, Yuanyuan Wang, Minghua Hu, Renhuai Cong, Lingyun Xiao, Chung Wah Ma
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Patent number: 10968495Abstract: Provided is a strain CCFM8631 of Lactobacillus reuteri and use thereof. The strain CCFM8631 of Lactobacillus reuteri can significantly increase neurotransmitter 5-hydroxytryptamine level in peripheral blood, recover the hormone levels, for example testosterone and so on in peripheral blood of rat, normalize abnormal abundances of Blautia genus and Turicibacter genus, Oscillospira genus and Bifidobacterium genus in intestinal flora of rat affected by high-fat high-starch diet, show good tolerance to simulated gastrointestinal fluid and quickly colonize in intestinal, significantly improve pathological damages of tissues such as liver, duodenum and so on, and increase triglyceride and total cholesterol levels in serum and oral glucose tolerance of rat with metabolic syndrome caused by high-fat high-starch diet.Type: GrantFiled: August 23, 2018Date of Patent: April 6, 2021Assignee: INFINITUS (CHINA) COMPANY LTD.Inventors: Fangli Ma, Wei Chen, Gang Wang, Guangsu Zhu, Yuanyuan Wang, Lingyun Xiao, Minghua Hu, Hao Zhang, Jianxin Zhao, Chung Wah Ma
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Patent number: 10967017Abstract: The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising GANODERMA polysaccharide, GRIFOLA FRONDOSA polysaccharide, ANGELICAE SINENSIS RADIX oil and CINNAMOMI CORTEX oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4+ and CD8+ cells in lymphocytes of the tumor stroma, increases body immune function, recovers normal immune surveillance function, decreases the expression rate of VEGF and TGF-? 1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor.Type: GrantFiled: August 9, 2018Date of Patent: April 6, 2021Assignee: INFINITUS (CHINA) COMPANY LTD.Inventors: Minghua Hu, Fangli Ma, Yuanyuan Wang, Chung Wah Ma, Renhuai Cong, Lingyun Xiao
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Patent number: 10960039Abstract: The present disclosure relates to the technical field of health care products and foodstuffs, in particular to a composition, a preparation method, and the use thereof in preparation of products for relieving thyroid nodules. The composition provided by the invention uses AtractylodisMacrocephalaeRhizoma and ChuanxiongRhizoma as raw materials, which show synergistic effect through rational combination. Experiments show that the composition provided by the invention can improve thyroid epithelial cell proliferation and reduce the thyroid index of thyroid nodules, and has the advantages of relieving thyroid nodules and protecting thyroid function. The invention has the advantages of simple combination, high safety, simple and easy handling and definite cure effect.Type: GrantFiled: January 12, 2018Date of Patent: March 30, 2021Assignee: INFINITUS (CHINA) COMPANY LTD.Inventors: Lingyun Xiao, Renhuai Cong, Yuanyuan Wang, Fangli Ma, Chung Wah Ma
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Patent number: 10744173Abstract: The present invention relates to the technical field of health-care product, and in particular relates to a traditional Chinese medicine composition having a function of regulating emotions, a process for preparing the same, and a product thereof. It was found that the composition of the present invention had effects of nourishing liver and kidney, regulating Yin and Yang, tonifying Qi and nourishing blood, regulating emotions, and protecting the function of autonomic nerve, and could improve pressure-induced anxiety and depression, inattention, poor spirit, dispirited, learning and memory capacity decline, etc. The invention has the advantages of specificity and remarkable effect, and it uses all natural medicinal and edible plants as raw materials, the combination of which is simple, safe and stable, and is suitable for long-term use.Type: GrantFiled: January 29, 2018Date of Patent: August 18, 2020Assignee: INFINITUS (CHINA) COMPANY LTD.Inventors: Lingyun Xiao, Renhuai Cong, Minghua Hu, Yuanyuan Wang, Fangli Ma, Chung Wah Ma
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Patent number: 10646537Abstract: The present disclosure relates to the field of health food technology, in particular to a traditional Chinese medicine composition, preparation method and use thereof. The traditional Chinese medicine composition is made from Coicis Semen, Hippophae Fructus, Citri Rubrum Exocarpium and Glycyrrhizae Radix et Rhizoma. The traditional Chinese medicine composition uses less species of Chinese herbs and has significant effect on reducing the circumference of waist and abdomen, reducing the weight of visceral fat and anti-inflammation by reasonable combination, and does not have side effects.Type: GrantFiled: October 24, 2017Date of Patent: May 12, 2020Assignee: INFINITUS (CHINA) COMPANY LTD.Inventors: Renhuai Cong, Fangli Ma, Chung Wah Ma, Xiaoling Wang, Lingyun Xiao
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Publication number: 20190112675Abstract: Provided is a strain CCFM8631 of Lactobacillus reuteri and use thereof. The strain CCFM8631 of Lactobacillus reuteri can significantly increase neurotransmitter 5-hydroxytryptamine level in peripheral blood, recover the hormone levels, for example testosterone and so on in peripheral blood of rat, normalize abnormal abundances of Blautia genus and Turicibacter genus, Oscillospira genus and Bifidobacterium genus in intestinal flora of rat affected by high-fat high-starch diet, show good tolerance to simulated gastrointestinal fluid and quickly colonize in intestinal, significantly improve pathological damages of tissues such as liver, duodenum and so on, and increase triglyceride and total cholesterol levels in serum and oral glucose tolerance of rat with metabolic syndrome caused by high-fat high-starch diet.Type: ApplicationFiled: August 23, 2018Publication date: April 18, 2019Applicant: INFINITUS (CHINA) COMPANY LTD.Inventors: Fangli MA, Wei CHEN, Gang WANG, Guangsu ZHU, Yuanyuan WANG, Lingyun XIAO, Minghua HU, Hao ZHANG, Jianxin ZHAO, Chung Wah MA
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Publication number: 20190112674Abstract: Provided is a strain CCFM8630 of Bifidobacterium adolescentis and use thereof. The strain CCFM8630 of Bifidobacterium adolescentis can significantly increase neurotransmitter 5-hydroxytryptamine level in peripheral blood of rat, recover the hormone levels, for example testosterone and so on in peripheral blood of rat, normalize abnormal abundances of Bifidobacterium genus, Blautia genus and Turicibacter genus in intestinal flora of rat affected by high-fat high-starch diet, show pretty good tolerance to simulated gastrointestinal fluid and quickly colonize in intestinal, significantly improve pathological damages of tissues such as liver, duodenum and so on, and increase triglyceride and total cholesterol levels in serum and oral glucose tolerance of rat with metabolic syndrome caused by high-fat high-starch diet.Type: ApplicationFiled: August 22, 2018Publication date: April 18, 2019Applicant: INFINITUS (CHINA) COMPANY LTD.Inventors: Yuanyuan WANG, Wei CHEN, Gang WANG, Guangsu ZHU, Fangli MA, Lingyun XIAO, Minghua HU, Hao ZHANG, Jianxin ZHAO, Chung Wah MA
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Publication number: 20190070237Abstract: The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising GANODERMA polysaccharide, GRIFOLA FRONDOSA polysaccharide, ANGELICAE SINENSIS RADIX oil and CINNAMOMI CORTEX oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4+ and CD8+ cells in lymphocytes of the tumor stroma, increases body immune function, recovers normal immune surveillance function, decreases the expression rate of VEGF and TGF-? 1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor.Type: ApplicationFiled: August 9, 2018Publication date: March 7, 2019Applicant: INFINITUS (CHINA) COMPANY LTD.Inventors: Minghua HU, Fangli MA, Yuanyuan WANG, Chung Wah MA, Renhuai CONG, Lingyun XIAO
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Publication number: 20190070246Abstract: The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising LYCII FRUCTUS polysaccharide, POLYGONATI RHIZOMA polysaccharide, CARYOPHYLLI FLOS oil and CINNAMOMI CORTEX oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4+ and CD8+ cells in lymphocytes of the tumor stroma, increases body immune function, recovers normal immune surveillance function, decreases the expression rate of VEGF and TGF-? 1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor.Type: ApplicationFiled: August 8, 2018Publication date: March 7, 2019Applicant: INFINITUS (CHINA) COMPANY LTD.Inventors: Fangli MA, Yuanyuan WANG, Minghua HU, Renhuai CONG, Lingyun XIAO, Chung Wah MA
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Publication number: 20180369308Abstract: The present disclosure relates to the field of health care product and food technology, disclosing a Chinese herbal medicine composition having a function of relieving hypothyroidism, and preparation method and use thereof. The Chinese herbal medicine composition described in the present disclosure, in parts by weight, comprises: 10 to 100 parts of GINSENG RADIX ET RHIZOMA, 10 to 100 parts of LYCII FRUCTUS, and 6 to 60 parts of CINNAMOMI CORTEX. The Chinese herbal medicine composition described in the present disclosure adopts GINSENG RADIX ET RHIZOMA, LYCII FRUCTUS and CINNAMOMI CORTEX as starting materials, creates synergistic effects through rational combination. Experiments indicate that the Chinese herbal medicine composition described in the present disclosure can improve functions of the thyroid gland in rat hypothyroidism model, reduce serum VEGF level in the model, showing a function of relieving hypothyroidism and protecting the thyroid gland.Type: ApplicationFiled: June 22, 2018Publication date: December 27, 2018Applicant: INFINITUS (CHINA) COMPANY LTD.Inventors: Lingyun XIAO, Renhuai CONG, Minghua HU, Yuanyuan WANG, Fangli MA, Chung Wah MA
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Publication number: 20180344793Abstract: The present disclosure relates to the technical field of health care products and foodstuffs, in particular to a composition, a preparation method, and the use thereof in preparation of products for relieving thyroid nodules. The composition provided by the invention uses AtractylodisMacrocephalaeRhizoma and ChuanxiongRhizoma as raw materials, which show synergistic effect through rational combination. Experiments show that the composition provided by the invention can improve thyroid epithelial cell proliferation and reduce the thyroid index of thyroid nodules, and has the advantages of relieving thyroid nodules and protecting thyroid function. The invention has the advantages of simple combination, high safety, simple and easy handling and definite cure effect.Type: ApplicationFiled: January 12, 2018Publication date: December 6, 2018Applicant: INFINITUS (CHINA) COMPANY LTD.Inventors: Lingyun XIAO, Renhuai CONG, Yuanyuan WANG, Fangli MA, Chung Wah MA
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Publication number: 20180296618Abstract: The present invention relates to the technical field of health-care product, and in particular relates to a traditional Chinese medicine composition having a function of regulating emotions, a process for preparing the same, and a product thereof. It was found that the composition of the present invention had effects of nourishing liver and kidney, regulating Yin and Yang, tonifying Qi and nourishing blood, regulating emotions, and protecting the function of autonomic nerve, and could improve pressure-induced anxiety and depression, inattention, poor spirit, dispirited, learning and memory capacity decline, etc. The invention has the advantages of specificity and remarkable effect, and it uses all natural medicinal and edible plants as raw materials, the combination of which is simple, safe and stable, and is suitable for long-term use.Type: ApplicationFiled: January 29, 2018Publication date: October 18, 2018Applicant: Infinitus (China) Company Ltd.Inventors: Lingyun Xiao, Renhuai Cong, Minghua Hu, Yuanyuan Wang, Fangli Ma, Chung Wah Ma
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Publication number: 20180264058Abstract: The present disclosure relates to the field of health food technology, in particular to a traditional Chinese medicine composition, preparation method and use thereof. The traditional Chinese medicine composition is made from Poria, Angelicae Sinensis Radix, Aurantii Fructus Immaturus and Atractylodis Macrocephalae Rhizoma. The traditional Chinese medicine composition uses less species of Chinese herbs and has significant effect on reducing the circumference of waist and abdomen, reducing the weight of visceral fat and anti-inflammation by reasonable combination, and does not have side effects.Type: ApplicationFiled: October 24, 2017Publication date: September 20, 2018Applicant: INFINITUS (CHINA) COMPANY LTD.Inventors: Renhuai CONG, Fangli MA, Chung Wah MA, Xiaoling WANG, Lingyun XIAO
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Publication number: 20180264068Abstract: The present disclosure relates to the field of health food technology, in particular to a traditional Chinese medicine composition, preparation method and use thereof. The traditional Chinese medicine composition is made from Coicis Semen, Hippophae Fructus, Citri Rubrum Exocarpium and Glycyrrhizae Radix et Rhizoma. The traditional Chinese medicine composition uses less species of Chinese herbs and has significant effect on reducing the circumference of waist and abdomen, reducing the weight of visceral fat and anti-inflammation by reasonable combination, and does not have side effects.Type: ApplicationFiled: October 24, 2017Publication date: September 20, 2018Applicant: INFINITUS (CHINA) COMPANY LTD.Inventors: Renhuai CONG, Fangli MA, Chung Wah MA, Xiaoling WANG, Lingyun XIAO