Abstract: Disclosed are compounds and pharmaceutically acceptable salts thereof that may be used in the treatment of subjects in need thereof. The compounds disclosed herein may be inhibitors of tyrosine and threonine-specific cdc2-inhibitory kinase (Myt1). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and methods of their preparation and use.

Abstract: A continuous perfusion bioreactor for microbial synthesis of metallic nanoparticles provides synthesis of nanoparticles without washout of the microbial cells. The perfusion bioreactor includes an inlet fluidically coupled to a holding compartment with a first flow barrier, which disperses the medium into a reaction compartment suitable for culture of microbial cells which synthesize nanoparticles. A second flow barrier in the reaction compartment prevents washout of the microbial cells but enables collection of the nanoparticles suspended in depleted nutrient medium.

Abstract: Disclosed are compounds and pharmaceutically acceptable salts thereof that may be used in the treatment of subjects in need thereof. The compounds disclosed herein may be inhibitors of tyrosine and threonine-specific cdc2-inhibitory kinase (Myt1). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and methods of their preparation and use.

Abstract: Disclosed are compounds and pharmaceutically acceptable salts thereof that may be used in the treatment of subjects in need thereof. The compounds disclosed herein may be inhibitors of Ataxia-telangiectasia and RAD-3-related protein kinase (ATR). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and methods of their preparation and use.

Abstract: Disclosed are compounds and pharmaceutically acceptable salts thereof that may be used in the treatment of subjects in need thereof. The compounds disclosed herein may be inhibitors of Ataxia-telangiectasia and RAD-3-related protein kinase (ATR). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and methods of their preparation and use.

Abstract: Methods and systems for discovery of a set of nodes in a network. The method includes selecting a node amongst nodes in a group of nodes to be processed, implementing a discovery procedure for the selected node, including broadcasting a neighbor discovery request from a node currently selected on a shared transmission medium of the network, receiving at the node currently selected replies sent by neighbor nodes on the shared transmission medium and adding the neighbor nodes to the group of nodes to be processed and repeating the steps of selecting and instructing for other nodes in the group of nodes to be processed, until all nodes of the set are discovered. Implementing a link probing procedure after the discovery procedure, including sending one or more link probing messages for a measure of link quality and receiving replies comprising data related to the measure of link quality.

Abstract: A surfactant composition comprising two trisiloxane alkoxylate surfactants can provide synergistic improvements in at least spreading, adhering and/or uptake properties of chemical formulations containing those surfactants. A first surfactant having fewer than 10 alkylene oxide substituents is combined with a second surfactant of higher weight having 10 or more substituents. Compositions in accordance with the invention can lead to synergistically improved spread area as well as droplet adhesion of agrochemical sprays on plant surfaces.

Abstract: There is provided herein a low foam surfactant composition comprising: (a) di-trisiloxane alkoxylate component of the general formula (I): (R1R2R3SiO)2(R4)Si—R5—Si(R6)(OSiR7R8R9)2??(I); and, (b) mono-trisiloxane alkoxylate component of the general formula (II): (R12R13R14SiO)2Si(R15)R16??(II) wherein di-trisiloxane alkoxylate (I) is soluble in mono-trisiloxane alkoxylate and methods of making the same.

Abstract: Methods and systems for discovery of a set of nodes in a network. The method includes selecting a node amongst nodes in a group of nodes to be processed, implementing a discovery procedure for the selected node, including broadcasting a neighbor discovery request from a node currently selected on a shared transmission medium of the network, receiving at the node currently selected replies sent by neighbor nodes on the shared transmission medium and adding the neighbor nodes to the group of nodes to be processed and repeating the steps of selecting and instructing for other nodes in the group of nodes to be processed, until all nodes of the set are discovered. Implementing a link probing procedure after the discovery procedure, including sending one or more link probing messages for a measure of link quality and receiving replies comprising data related to the measure of link quality.

Abstract: Methods and systems for discovery of a set of nodes in a network. The method comprises selecting a node amongst nodes in a group of nodes to be processed; and instructing to implement a discovery procedure for the selected node. The procedure comprises broadcasting a neighbor discovery request from a node currently selected on a shared transmission medium of the network; and receiving at the node currently selected replies sent by neighbor nodes on the shared transmission medium and adding the neighbor nodes to the group of nodes to be processed; and repeating the steps of selecting and instructing for other nodes in the group of nodes to be processed, until all nodes of the set are discovered.

Abstract: Apparatuses, systems, methods, and computer program products are disclosed for annealing non-volatile memory. A controller identifies one or more life cycle characteristics of a non-volatile storage element. The controller selects an anneal duration and an anneal temperature for annealing the non-volatile storage element. The anneal duration and the anneal temperature are based on the one or more life cycle characteristics. The controller anneals the non-volatile storage element using the selected anneal duration and anneal temperature.

Abstract: There is provided herein a low foam surfactant composition comprising: (a) di-trisiloxane alkoxylate component of the general formula (I): (R1R2R3SiO)2(R4)Si—R5—Si(R6)(OSiR7R8R9)2??(I); and, (b) mono-trisiloxane alkoxylate component of the general formula (II): (R12R13R14SiO)2Si(R15)R16??(II) wherein di-trisiloxane alkoxylate (I) is soluble in mono-trisiloxane alkoxylate and methods of making the same.

Abstract: There is provided herein a low foam surfactant composition comprising: (a) di-trisiloxane alkoxylate component of the general formula (I): (R1R2R3SiO)2(R4)Si—R5—Si(R6)(OSiR7R8R9)2??(I); and, (b) mono-trisiloxane alkoxylate component of the general formula (II): (R12R13R14SiO)2Si(R15)R16??(II) wherein di-trisiloxane alkoxylate (I) is soluble in mono-trisiloxane alkoxylate and methods of making the same.

Abstract: Methods and systems for discovery of a set of nodes in a network. The method comprises selecting a node amongst nodes in a group of nodes to be processed; and instructing to implement a discovery procedure for the selected node. The procedure comprises broadcasting a neighbor discovery request from a node currently selected on a shared transmission medium of the network; and receiving at the node currently selected replies sent by neighbor nodes on the shared transmission medium and adding the neighbor nodes to the group of nodes to be processed; and repeating the steps of selecting and instructing for other nodes in the group of nodes to be processed, until all nodes of the set are discovered.

Abstract: Methods and systems for discovery of a set of nodes in a network. The method comprises selecting a node amongst nodes in a group of nodes to be processed; and instructing to implement a discovery procedure for the selected node. The-procedure comprises broadcasting a neighbor discovery request from a node currently selected on a shared transmission medium of the network; and receiving at the node currently selected replies sent by neighbor nodes on the shared transmission medium and adding the neighbor nodes to the group of nodes to be processed; and repeating the steps of selecting and instructing for other nodes in the group of nodes to be processed, until all nodes of the set are discovered.

Abstract: The present invention is directed to 2,6-morpholine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein Z1, Z2, V1, V2, V3, R6, R6A, and X are defined herein. The invention also relates to methods of using the 2,6-morpholine derivatives of the invention for the inhibition of HV protease, the inhibition of HV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Abstract: Apparatuses, systems, methods, and computer program products are disclosed for annealing non-volatile memory. A controller identifies one or more life cycle characteristics of a non-volatile storage element. The controller selects an anneal duration and an anneal temperature for annealing the non-volatile storage element. The anneal duration and the anneal temperature are based on the one or more life cycle characteristics. The controller anneals the non-volatile storage element using the selected anneal duration and anneal temperature.

Abstract: The present invention is directed to 2,5,6-substituted morpholine derivatives and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Abstract: A method for transmitting data to and from nodes of a multi-hop network with a Time Division Multiple Access (TDMA) scheme is suggested. The network is clustered into N clusters, wherein each cluster of the N clusters has at least one of the nodes. In a first step, the TDMA scheme is organized by periodic superframes. Each superframe of the periodic superframes has a number of frames including at least one broadcast frame and one collection frame for the N clusters. In a second step, one dedicated communication channel is shared by the N clusters within the broadcast frame. In a third step, N separate communication channels are used by the N clusters within the collection frame.

Abstract: The present invention is directed to 5-heteroarylmorpholine derivatives and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.