Patents by Inventor Linnette OCARIZA

Linnette OCARIZA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR INHIBITING COMPLEMENT ACTIVATION AND USES THEREOF
    Publication number: 20170035804
    Abstract: The present invention provides methods for inhibiting complement activation and uses thereof. More specifically, the present invention provides methods for inhibiting complement activation using inorganic polyphosphates of at least 10 phosphate units. The polyphosphates inhibit complement activation by one or more of: binding to the C6 complement protein, C1-esterase inhibitor (C1-inh), factor H or factor B; enhancing the activity of C1-inh; interfering with C1s-mediated cleavage of C2; destabilizing the C5b-6 complement protein complex; interfering with C5b,6 interaction with C7; interfering with binding of C5b-7 to a cell membrane; interfering with integration of C5b-7 into a cell membrane; interfering with binding of C5b-8 to a cell membrane; interfering with integration of C5b-8 into a cell membrane; destabilizing the membrane attack complex (MAC); or reducing the amount of C5b-9 deposited on a cell surface.
    Type: Application
    Filed: July 14, 2016
    Publication date: February 9, 2017
    Inventors: Edward CONWAY, Jing Zhao CUI, Jonathan FOLEY, Michael KRISINGER, Joanne MATSUBARA, Linnette OCARIZA, Jovian WAT
  • Methods for inhibiting complement activation and uses thereof
    Patent number: 9408871
    Abstract: The present invention provides methods for inhibiting complement activation and uses thereof. More specifically, the present invention provides methods for inhibiting complement activation using inorganic polyphosphates of at least 10 phosphate units. The polyphosphates inhibit complement activation by one or more of: binding to the C6 complement protein, C1-esterase inhibitor (C1-inh), factor H or factor B; enhancing the activity of C1-inh; interfering with C1s-mediated cleavage of C2; destabilizing the C5b-6 complement protein complex; interfering with C5b,6 interaction with C7; interfering with binding of C5b-7 to a cell membrane; interfering with integration of C5b-7 into a cell membrane; interfering with binding of C5b-8 to a cell membrane; interfering with integration of C5b-8 into a cell membrane; destabilizing the membrane attack complex (MAC); or reducing the amount of C5b-9 deposited on a cell surface.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: August 9, 2016
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Edward Conway, Jing Zhao Cui, Jonathan Foley, Michael Krisinger, Joanne Matsubara, Linnette Ocariza, Jovian Wat
  • METHODS FOR INHIBITING COMPLEMENT ACTIVATION AND USES THEREOF
    Publication number: 20150132403
    Abstract: The present invention provides methods for inhibiting complement activation and uses thereof. More specifically, the present invention provides methods for inhibiting complement activation using polyphosphates.
    Type: Application
    Filed: November 7, 2014
    Publication date: May 14, 2015
    Inventors: Edward CONWAY, Jing Zhou CUI, Jonathan FOLEY, Michael KRISINGER, Joanne MATSUBARA, Linnette OCARIZA, Jovian WAT