Patents by Inventor Lionel N. Simon

Lionel N. Simon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6005094
    Abstract: Acid resistant Oligomers suitable for oral administration, orally acceptable formulations of such Oligomers and preparation of pharmaceutical formations of such Oligomers are provided.
    Type: Grant
    Filed: December 27, 1994
    Date of Patent: December 21, 1999
    Assignees: Genta Incorporated, The Johns Hopkins University
    Inventors: Lionel N. Simon, Paul S. Miller, Paul O. P. Ts'o
  • Patent number: 4602089
    Abstract: There are prepared compounds of the formulae ##STR1## where R is lower alkyl, chlorine, or bromine and n is an integer from 1 to 5. The compounds of formula (1) can be used to make erythro-9-(2-hydroxy-3-nonyl) hypoxanthine and its homologues and also to make the compounds of formulae (2) and (3). All three classes of compounds are useful as immunomodulators.
    Type: Grant
    Filed: February 21, 1984
    Date of Patent: July 22, 1986
    Assignee: Newport Pharmaceuticals, Inc.
    Inventors: Lionel N. Simon, Hans-Rudolf Mueller, Hans Zutter
  • Patent number: 4510144
    Abstract: There are prepared compounds of the formulae ##STR1## Where R.sup.1 is H, lower alkyl S--, ##STR2## NH.sub.2 or halogen, R.sup.2 is OH, lower alkyl S--, halogen, NH.sub.2 or SH,R is OH, SH, lower alkyl S--, or halogen andR.sup.3 is OH, SH, lower alkyl S--, halogen or NH.sub.2.The compounds have antiviral and immuno-modulating activity.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: April 9, 1985
    Assignee: Newport Pharmaceuticals International
    Inventors: John W. Hadden, Lionel N. Simon, Alfredo Giner-Sorolla
  • Patent number: 4457919
    Abstract: There are prepared compounds of the formula ##STR1## where R.sup.1 is alkyl of 1 to 8 carbon atoms and R.sup.2 is the ester group of an unsubstituted monocarboxylic acid, aromatic carboxylic acid, aminocarboxylic acid, unsubstituted dicarboxylic acid, phosphoric acid, or nitric acid or a glycoside or an acetaldehyde acetal. The compounds are immunomodulators, have antiviral activity and antitumor activity and also are enzyme inhibitors. The compounds can also be used to introduce the corresponding alcohol into biological systems, in some cases with enhanced potency.
    Type: Grant
    Filed: May 17, 1982
    Date of Patent: July 3, 1984
    Assignees: Newport Pharmaceutical International, Inc., Sloan-Kettering Institute
    Inventors: Lionel N. Simon, Alfredo Giner-Sorolla, Alvin Guttag
  • Patent number: 4451478
    Abstract: There are prepared compounds of the formulae ##STR1## where R is lower alkyl, chlorine, or bromine and n is an integer from 1 to 5. The compounds of formula (1) can be used to make erythro-9-(2-hydroxy-3-nonyl) hypoxanthine and its homologues and also to make the compounds of formulae (2) and (3). All three classes of compounds are useful as immunomodulators.
    Type: Grant
    Filed: March 12, 1982
    Date of Patent: May 29, 1984
    Assignee: Newport Pharmaceuticals International, Inc.
    Inventors: Lionel N. Simon, Hans-Rudolf Mueller, Hans Zutter
  • Patent number: 4423027
    Abstract: A new solid or liquid dosage form containing deglycyrrhizinated licorice (DGL) has been designed. This form is more suitable for administration to humans than the form previously used because:(1) irritating ingredients, previously included, possessing no activity, have been removed,(2) bulky, ineffective quantities of antacids have been removed, thereby allowing the amount of the active ingredient DGL to be increased per unit, reducing the number of units needed to be consumed (e.g. from 8 to 4 per day),(3) dangerous, neurotoxic ingredients have been removed, and(4) the bitter DGL has been formulated into an acceptable pharmaceutical dosage form that does not need to be chewed because, unlike other formulations, this formulation is formulated in a novel way that allows for complete and rapid disintegration, releasing the active ingredient in a fashion superior to chewing.
    Type: Grant
    Filed: December 22, 1982
    Date of Patent: December 27, 1983
    Inventors: Lionel N. Simon, Kameron W. Maxwell
  • Patent number: 4387226
    Abstract: There are prepared compound of the formulae ##STR1## Where R.sup.1 is H, lower alkyl S--, lower alkyl ##STR2## NH.sub.2 or halogen, R.sup.2 is OH, lower alkyl S--, halogen, NH.sub.2 or SHR is OH, SH, lower alkyl S--, or halogen andR.sup.3 is OH, SH, lower alkyl S--, halogen or NH.sub.2.The compounds have antiviral and immunomodulating activity.
    Type: Grant
    Filed: August 26, 1981
    Date of Patent: June 7, 1983
    Assignees: Newport Pharmaceuticals International, Inc., Sloan-Kettering Institute For Cancer Research
    Inventors: John W. Hadden, Lionel N. Simon, Alfredo Giner-Sorolla
  • Patent number: 4340726
    Abstract: There are prepared compounds of the formula ##STR1## where R.sup.1 is alkyl of 1 to 8 carbon atoms and R.sup.2 is the ester group of an unsubstituted monocarboxylic acid, aromatic carboxylic acid, aminocarboxylic acid, unsubstituted dicarboxylic acid, phosphoric acid, or nitric acid or a glycoside or an acetaldehyde acetal. The compounds are immunomodulators, have antiviral activity and antitumor activity and also are enzyme inhibitors. The compounds can also be used to introduce the corresponding alcohol into biological systems, in some cases with enhanced potency.
    Type: Grant
    Filed: March 14, 1980
    Date of Patent: July 20, 1982
    Assignees: Newport Pharmaceuticals International, Inc., Sloan-Kettering Institute for Cancer Research
    Inventors: Lionel N. Simon, Alfredo Giner-Sorolla, Alvin Guttag
  • Patent number: 4221909
    Abstract: Compounds of the formula ##STR1## where X is OH, NH.sub.2, SH, OR or SR (where R is alkyl of 1 to 4 carbon atoms or benzyl), R.sup.1 is H or alkyl of 1 to 8 carbon atoms, R.sup.2 is H or methyl, Y is the salt of an amine of the formula ##STR2## where R.sup.3 and R.sup.4 are lower alkyl, e.g., 1 to 4 carbon atoms and n is an integer of 2 to 4 with p-acetamidobenzoic acid and where z is a number from 0 to 10are useful as immunomodulators, as antiviral agents and in specific cases have anti-leukemic activity. The compounds and compositions where z is 1 to 10 are novel per se. When R.sup.2 is H the presence of Y enhances the immunoregulatory activity and the antiviral activity. If X is the NH.sub.2 there is immunoinhibitory activity but no immunostimulatory (immunopotentiatory) activity.
    Type: Grant
    Filed: September 15, 1978
    Date of Patent: September 9, 1980
    Assignees: Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Instit. for Cancer Res.
    Inventors: Lionel N. Simon, John W. Hadden
  • Patent number: 4221794
    Abstract: Compounds of the formula ##STR1## where X is OH, NH.sub.2, SH, OR or SR (where R is alkyl of 1 to 4 carbon atoms or benzyl), R.sup.1 is H or alkyl of 1 to 8 carbon atoms, R.sup.2 is H or methyl, Y is the salt of an amine of the formula ##STR2## where R.sup.3 and R.sup.4 are lower alkyl, e.g., 1 to 4 carbon atoms and n is an integer of 2 to 4 with p-acetamidobenzoic acid and where z is a number from 0 to 10 are useful as immunomodulators, as antiviral agents and in specific cases have anti-leukemic activity. The compounds and compositions where z is 1 to 10 are novel per se. When R.sup.2 is H the presence of Y enhances the immunoregulatory activity and the antiviral activity. If X is the NH.sub.2 there is immunoinhibitory activity but no immunostimulatory (immunopotentiatory) activity.
    Type: Grant
    Filed: June 21, 1979
    Date of Patent: September 9, 1980
    Assignees: Newport Pharmaceuticals International, Inc., Sloan-Kettering Institute for Cancer Research
    Inventors: Lionel N. Simon, John W. Hadden
  • Patent number: 4021556
    Abstract: Compounds of the following structure are disclosed which are effective inhibitors of the enzyme xanthine oxidase: ##STR1## R is an aromatic or substituted aromatic nucleus such as phenyl, R.sub.1 is H, an alkali metal or ammonium, and R.sub.2 is H or OR.sub.1.
    Type: Grant
    Filed: November 17, 1975
    Date of Patent: May 3, 1977
    Assignee: ICN Pharmaceuticals, Inc.
    Inventors: Robert H. Springer, Darrell E. O'Brien, Lionel N. Simon