Patents by Inventor Lionel N. Simon
Lionel N. Simon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6005094Abstract: Acid resistant Oligomers suitable for oral administration, orally acceptable formulations of such Oligomers and preparation of pharmaceutical formations of such Oligomers are provided.Type: GrantFiled: December 27, 1994Date of Patent: December 21, 1999Assignees: Genta Incorporated, The Johns Hopkins UniversityInventors: Lionel N. Simon, Paul S. Miller, Paul O. P. Ts'o
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Patent number: 4602089Abstract: There are prepared compounds of the formulae ##STR1## where R is lower alkyl, chlorine, or bromine and n is an integer from 1 to 5. The compounds of formula (1) can be used to make erythro-9-(2-hydroxy-3-nonyl) hypoxanthine and its homologues and also to make the compounds of formulae (2) and (3). All three classes of compounds are useful as immunomodulators.Type: GrantFiled: February 21, 1984Date of Patent: July 22, 1986Assignee: Newport Pharmaceuticals, Inc.Inventors: Lionel N. Simon, Hans-Rudolf Mueller, Hans Zutter
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Patent number: 4510144Abstract: There are prepared compounds of the formulae ##STR1## Where R.sup.1 is H, lower alkyl S--, ##STR2## NH.sub.2 or halogen, R.sup.2 is OH, lower alkyl S--, halogen, NH.sub.2 or SH,R is OH, SH, lower alkyl S--, or halogen andR.sup.3 is OH, SH, lower alkyl S--, halogen or NH.sub.2.The compounds have antiviral and immuno-modulating activity.Type: GrantFiled: September 30, 1982Date of Patent: April 9, 1985Assignee: Newport Pharmaceuticals InternationalInventors: John W. Hadden, Lionel N. Simon, Alfredo Giner-Sorolla
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Patent number: 4457919Abstract: There are prepared compounds of the formula ##STR1## where R.sup.1 is alkyl of 1 to 8 carbon atoms and R.sup.2 is the ester group of an unsubstituted monocarboxylic acid, aromatic carboxylic acid, aminocarboxylic acid, unsubstituted dicarboxylic acid, phosphoric acid, or nitric acid or a glycoside or an acetaldehyde acetal. The compounds are immunomodulators, have antiviral activity and antitumor activity and also are enzyme inhibitors. The compounds can also be used to introduce the corresponding alcohol into biological systems, in some cases with enhanced potency.Type: GrantFiled: May 17, 1982Date of Patent: July 3, 1984Assignees: Newport Pharmaceutical International, Inc., Sloan-Kettering InstituteInventors: Lionel N. Simon, Alfredo Giner-Sorolla, Alvin Guttag
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Patent number: 4451478Abstract: There are prepared compounds of the formulae ##STR1## where R is lower alkyl, chlorine, or bromine and n is an integer from 1 to 5. The compounds of formula (1) can be used to make erythro-9-(2-hydroxy-3-nonyl) hypoxanthine and its homologues and also to make the compounds of formulae (2) and (3). All three classes of compounds are useful as immunomodulators.Type: GrantFiled: March 12, 1982Date of Patent: May 29, 1984Assignee: Newport Pharmaceuticals International, Inc.Inventors: Lionel N. Simon, Hans-Rudolf Mueller, Hans Zutter
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Patent number: 4423027Abstract: A new solid or liquid dosage form containing deglycyrrhizinated licorice (DGL) has been designed. This form is more suitable for administration to humans than the form previously used because:(1) irritating ingredients, previously included, possessing no activity, have been removed,(2) bulky, ineffective quantities of antacids have been removed, thereby allowing the amount of the active ingredient DGL to be increased per unit, reducing the number of units needed to be consumed (e.g. from 8 to 4 per day),(3) dangerous, neurotoxic ingredients have been removed, and(4) the bitter DGL has been formulated into an acceptable pharmaceutical dosage form that does not need to be chewed because, unlike other formulations, this formulation is formulated in a novel way that allows for complete and rapid disintegration, releasing the active ingredient in a fashion superior to chewing.Type: GrantFiled: December 22, 1982Date of Patent: December 27, 1983Inventors: Lionel N. Simon, Kameron W. Maxwell
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Patent number: 4387226Abstract: There are prepared compound of the formulae ##STR1## Where R.sup.1 is H, lower alkyl S--, lower alkyl ##STR2## NH.sub.2 or halogen, R.sup.2 is OH, lower alkyl S--, halogen, NH.sub.2 or SHR is OH, SH, lower alkyl S--, or halogen andR.sup.3 is OH, SH, lower alkyl S--, halogen or NH.sub.2.The compounds have antiviral and immunomodulating activity.Type: GrantFiled: August 26, 1981Date of Patent: June 7, 1983Assignees: Newport Pharmaceuticals International, Inc., Sloan-Kettering Institute For Cancer ResearchInventors: John W. Hadden, Lionel N. Simon, Alfredo Giner-Sorolla
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Patent number: 4340726Abstract: There are prepared compounds of the formula ##STR1## where R.sup.1 is alkyl of 1 to 8 carbon atoms and R.sup.2 is the ester group of an unsubstituted monocarboxylic acid, aromatic carboxylic acid, aminocarboxylic acid, unsubstituted dicarboxylic acid, phosphoric acid, or nitric acid or a glycoside or an acetaldehyde acetal. The compounds are immunomodulators, have antiviral activity and antitumor activity and also are enzyme inhibitors. The compounds can also be used to introduce the corresponding alcohol into biological systems, in some cases with enhanced potency.Type: GrantFiled: March 14, 1980Date of Patent: July 20, 1982Assignees: Newport Pharmaceuticals International, Inc., Sloan-Kettering Institute for Cancer ResearchInventors: Lionel N. Simon, Alfredo Giner-Sorolla, Alvin Guttag
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Patent number: 4221909Abstract: Compounds of the formula ##STR1## where X is OH, NH.sub.2, SH, OR or SR (where R is alkyl of 1 to 4 carbon atoms or benzyl), R.sup.1 is H or alkyl of 1 to 8 carbon atoms, R.sup.2 is H or methyl, Y is the salt of an amine of the formula ##STR2## where R.sup.3 and R.sup.4 are lower alkyl, e.g., 1 to 4 carbon atoms and n is an integer of 2 to 4 with p-acetamidobenzoic acid and where z is a number from 0 to 10are useful as immunomodulators, as antiviral agents and in specific cases have anti-leukemic activity. The compounds and compositions where z is 1 to 10 are novel per se. When R.sup.2 is H the presence of Y enhances the immunoregulatory activity and the antiviral activity. If X is the NH.sub.2 there is immunoinhibitory activity but no immunostimulatory (immunopotentiatory) activity.Type: GrantFiled: September 15, 1978Date of Patent: September 9, 1980Assignees: Sloan-Kettering Institute for Cancer Research, Sloan-Kettering Instit. for Cancer Res.Inventors: Lionel N. Simon, John W. Hadden
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Patent number: 4221794Abstract: Compounds of the formula ##STR1## where X is OH, NH.sub.2, SH, OR or SR (where R is alkyl of 1 to 4 carbon atoms or benzyl), R.sup.1 is H or alkyl of 1 to 8 carbon atoms, R.sup.2 is H or methyl, Y is the salt of an amine of the formula ##STR2## where R.sup.3 and R.sup.4 are lower alkyl, e.g., 1 to 4 carbon atoms and n is an integer of 2 to 4 with p-acetamidobenzoic acid and where z is a number from 0 to 10 are useful as immunomodulators, as antiviral agents and in specific cases have anti-leukemic activity. The compounds and compositions where z is 1 to 10 are novel per se. When R.sup.2 is H the presence of Y enhances the immunoregulatory activity and the antiviral activity. If X is the NH.sub.2 there is immunoinhibitory activity but no immunostimulatory (immunopotentiatory) activity.Type: GrantFiled: June 21, 1979Date of Patent: September 9, 1980Assignees: Newport Pharmaceuticals International, Inc., Sloan-Kettering Institute for Cancer ResearchInventors: Lionel N. Simon, John W. Hadden
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Patent number: 4021556Abstract: Compounds of the following structure are disclosed which are effective inhibitors of the enzyme xanthine oxidase: ##STR1## R is an aromatic or substituted aromatic nucleus such as phenyl, R.sub.1 is H, an alkali metal or ammonium, and R.sub.2 is H or OR.sub.1.Type: GrantFiled: November 17, 1975Date of Patent: May 3, 1977Assignee: ICN Pharmaceuticals, Inc.Inventors: Robert H. Springer, Darrell E. O'Brien, Lionel N. Simon