Patents by Inventor Lionel Vedrine
Lionel Vedrine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11957870Abstract: The subject invention provides a drug delivery device for injecting medicament which includes a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.Type: GrantFiled: February 26, 2021Date of Patent: April 16, 2024Assignee: Becton, Dickinson and CompanyInventors: Richard A Cronenberg, Lionel Vedrine, Paul Alchas
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Publication number: 20240091100Abstract: The needless vial assemblies described herein allow for the access to the contents of a vial, such as a medication, using a syringe without a needle. In some designs, the vial includes a vial neck, which is itself a syringe interface. The vial assemblies also include a cap with a plug, which can be used to seal the vial assembly. The present disclosure further provides methods of filling a vial assembly and methods of filling a syringe using the vial assemblies described herein.Type: ApplicationFiled: November 15, 2023Publication date: March 21, 2024Applicant: Genentech, Inc.Inventors: Geoffrey WISE, Ajay DESHMUKH, Lionel VEDRINE
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Patent number: 11844938Abstract: Apparatus and methods for delivering medicament. The apparatus may include a fitting for a fluid dispenser. The fitting may include a detent that is configured to limit insertion of the dispenser into the fitting by contacting a terminal surface of the dispenser; and a seal for sealing against the surface. The apparatus may include an insert for the fitting. The insert may include a gasket to seal against the terminal surface of the dispenser; a proximal rim to engage a lateral wall of the dispenser; and a connector fixed to the gasket and the rim. The apparatus may include a coupler to engage a pre-filled dispenser; and a body defining a passageway that is configured to be placed in fluid communication with the dispenser. The apparatus may include a dispenser that includes a detent and a seal. The detent may limit insertion of the dispenser into a fitting.Type: GrantFiled: May 15, 2019Date of Patent: December 19, 2023Assignee: Genentech, Inc.Inventors: Lionel Vedrine, Ariel Waitz
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Patent number: 11771843Abstract: A syringe (18) has a longitudinal body (28) with an interior (228) in which a pharmaceutical substance is arranged, a needle connected to one longitudinal end of the body (228) and a rigid needle shield (38) encasing the needle. The rigid needle shield (38) is essentially water vapour tight. The syringe (18) according to the invention allows for preventing needle clogging and, thus, proper provision of pharmaceuticals, particularly by subcutaneous, intramuscular or ocular injection.Type: GrantFiled: February 18, 2022Date of Patent: October 3, 2023Assignees: HOFFMANN-LA ROCHE INC., GENENTECH, INC.Inventors: Frank Bamberg, Heather L. Flores, Robert Müller, Elisabeth Schaible, Edward Schwarb, Lionel Vedrine, Kewei Yang, Mathieu Rigollet, Pierre Goldbach, Baboo Dushyantsingh Goordyal, Ivy Lin, Florian Wildenhahn
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Publication number: 20230201468Abstract: Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.Type: ApplicationFiled: March 2, 2023Publication date: June 29, 2023Inventors: Lionel Vedrine, Steven N. Roe, Mukund Patel
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Patent number: 11633545Abstract: Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.Type: GrantFiled: July 17, 2020Date of Patent: April 25, 2023Assignee: Genentech, Inc.Inventors: Lionel Vedrine, Steven N. Roe, Mukund Patel
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Patent number: 11623037Abstract: The subject invention provides a drug delivery device for injecting medicament which includes a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.Type: GrantFiled: June 30, 2020Date of Patent: April 11, 2023Assignee: Becton, Dickinson and CompanyInventors: Richard A. Cronenberg, Lionel Vedrine, Paul Alchas
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Patent number: 11571506Abstract: Apparatus and methods for delivering medicament to a patient. The apparatus may include elements with different capacities to attenuate or absorb sterilizing radiation. The apparatus may include a medicament delivery assembly with interactive elements for dose-setting, priming and medicament ejection. The assembly may include a chamber housing a radiation-sensitive medicament present in the apparatus during sterilization by electron beam. The assembly may include an actuator chassis, a drive mechanism, a needle-priming mechanism and a fluid-displacement mechanism including a fluid-displacement member. The chassis may be fixed, relative to an outlet, to the chamber. The member may be slidingly and/or threadingly engaged with the chassis, and may be configured to move relative to the outlet to deliver the medicament through the outlet. Assembly elements may be nested coaxially and/or stacked axially. The assembly may include at least one hollow region.Type: GrantFiled: April 15, 2019Date of Patent: February 7, 2023Assignee: Genentech, Inc.Inventors: Joshua Horvath, Lionel Vedrine, Nathan A. Goltz, Mukund R. Patel, Aaron D. Chesterman, Mayumi Naito Bowen
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Patent number: 11523969Abstract: Apparatus and methods for lyophilizing and sealing a medicament within a medical delivery device having an opening. The apparatus may include a stopper for sealing the opening. The stopper may have one or more elongated members extending from a base, in a direction that is parallel to a central axis of the base. One or more of the members may be set radially away from the axis and define a coaxial central well. The member or members may define a void. The elongated member or members may engage a device inner wall and support the base away from the opening. The void may provide gas exchange between a device interior and a device exterior. The gas may be a lyophilization byproduct that escapes from the device interior between the inner wall, the base and the member or members. The stopper may be advanced into the device to seal the opening.Type: GrantFiled: April 21, 2020Date of Patent: December 13, 2022Assignee: Genentech, Inc.Inventor: Lionel Vedrine
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Publication number: 20220378609Abstract: An ocular implant system including an ocular implant sized and shaped to be inserted at least partially into an eye; a carrier member with a shell having a central channel extending at least partially through the shell from a proximal end towards a distal end of the shell. A guide sleeve removably attached within at least a first region of the central channel of the shell and defining a proximal port into the central channel that is accessible from the proximal end of the shell. An implant holder removably attached within at least a second region of the central channel of the shell adjacent to a distal end of the guide sleeve and having a pair of graspers adapted to releasably secure the implant at a distal end of the implant holder. Related devices, systems, and/or methods are described.Type: ApplicationFiled: May 16, 2022Publication date: December 1, 2022Inventors: Keith Bianchi, Bill Hartsig, Scott Nunn, Mukund Patel, Mark Sponsel, Lionel Vedrine, Ariel Waitz
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Patent number: 11471592Abstract: Provided is an extended use self-contained, wearable medical device. The device is preferably configured with an infusion deployment mechanism for variably inserting and retracting an infusion needle to different depths, or completely retracting the infusion needle from the infusion site and then re-inserting the infusion needle after a predetermined period of time, throughout an infusion cycle for extending the viability of the infusion site. Another embodiment comprises dual needle deployment mechanisms which may also variably insert and retract the infusion needles. A flow sensor is preferably provided for detecting the stoppage of flow through the infusion cannula and signaling the needle deployment mechanism to attempt infusion at a different depth or to deploy a second infusion needle. A re-fillable reservoir assembly is preferably provided for supplying a drug over the extended use of the device.Type: GrantFiled: June 3, 2016Date of Patent: October 18, 2022Assignee: BECTON, DICKINSON AND COMPANYInventors: Gary Searle, Keith N Knapp, II, Roman Tunkel, Peter Skutnik, Lionel Vedrine
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Patent number: 11452816Abstract: In one aspect of the subject invention, a drug delivery device is provided which includes a reservoir for containing a medicament and has a proximal end and a distal end, the medicament including a suspension of solids in a liquid carrier. Further, the drug delivery device includes a needle in fluid communication with the reservoir and having a distal end for injection into a patient, and a proximal end in the reservoir. An accumulation surface is defined at least partially about the needle, distally of the proximal end of the needle. The accumulation surface defines a distally-extending indentation which is sized and shaped to collect, during use, solids that come out of suspension. Advantageously, with the subject invention, the accumulation surface allows for solids to accumulate at a location spaced from the proximal end of the needle, thereby minimizing the possibility of clogging the needle.Type: GrantFiled: January 2, 2019Date of Patent: September 27, 2022Assignee: Becton, Dickinson and CompanyInventors: Roger Groskopf, Lionel Vedrine, Michael C. Ratigan
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Publication number: 20220203041Abstract: A syringe (18) has a longitudinal body (28) with an interior (228) in which a pharmaceutical substance is arranged, a needle connected to one longitudinal end of the body (228) and a rigid needle shield (38) encasing the needle. The rigid needle shield (38) is essentially water vapour tight. The syringe (18) according to the invention allows for preventing needle clogging and, thus, proper provision of pharmaceuticals, particularly by subcutaneous, intramuscular or ocular injection.Type: ApplicationFiled: February 18, 2022Publication date: June 30, 2022Inventors: Frank BAMBERG, Heather L. FLORES, Robert MÜLLER, Elisabeth SCHAIBLE, Edward SCHWARB, Lionel VEDRINE, Kewei YANG, Mathieu RIGOLLET, Pierre GOLDBACH, Baboo Dushyantsingh GOORDYAL, Ivy LIN, Florian WILDENHAHN
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Patent number: 11337853Abstract: An ocular implant system including an ocular implant sized and shaped to be inserted at least partially into an eye; a carrier member with a shell having a central channel extending at least partially through the shell from a proximal end towards a distal end of the shell. A guide sleeve removably attached within at least a first region of the central channel of the shell and defining a proximal port into the central channel that is accessible from the proximal end of the shell. An implant holder removably attached within at least a second region of the central channel of the shell adjacent to a distal end of the guide sleeve and having a pair of graspers adapted to releasably secure the implant at a distal end of the implant holder. Related devices, systems, and/or methods are described.Type: GrantFiled: April 10, 2019Date of Patent: May 24, 2022Assignee: ForSight Vision4, Inc.Inventors: Keith Bianchi, Bill Hartsig, Scott Nunn, Mukund Patel, Mark Sponsel, Lionel Vedrine, Ariel Waitz
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Patent number: 11202857Abstract: The subject invention provides a drug delivery device for injecting medicament which includes a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.Type: GrantFiled: September 17, 2019Date of Patent: December 21, 2021Assignee: Becton, Dickinson and CompanyInventors: Richard A. Cronenberg, Lionel Vedrine, Paul Alchas
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Publication number: 20210178057Abstract: The subject invention provides a drug delivery device for injecting medicament which includes a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.Type: ApplicationFiled: February 26, 2021Publication date: June 17, 2021Applicant: Becton, Dickinson and CompanyInventors: Richard A. Cronenberg, Lionel Vedrine, Paul Alchas
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Patent number: 11007316Abstract: A device (100) for delivering a medicament into a patient's body by injection into or through the patient's skin, including a main body having a top enclosure (116) and a bottom enclosure (104), a reservoir (160) disposed within the main body for containing the medicament, and an injection needle (152) for penetrating the skin of the patient, the needle (152) having a lumen and selectively communicating with the reservoir (160). The device also includes a pressurizing system (600, 140) for selectively pressurizing the reservoir (160). In a pre-activated position, the pressurizing system (600, 140) contacts and compresses the reservoir (160) to reduce the initial volume of the reservoir (160), thereby allowing for partial filling of the reservoir (160).Type: GrantFiled: February 8, 2019Date of Patent: May 18, 2021Assignee: Becton, Dickinson and CompanyInventors: Lionel Vedrine, Ralph Sonderegger, Curt Bingham
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Publication number: 20210138158Abstract: Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.Type: ApplicationFiled: July 17, 2020Publication date: May 13, 2021Inventors: Lionel Vedrine, Steven N. Roe, Mukund Patel
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Patent number: 10967123Abstract: A device (100) for delivering a medicament into a patient's body by injection into or through the patient's skin, including a main body having a top enclosure (116) and a bottom enclosure (104), a reservoir (160) disposed within the main body for containing the medicament, and an injection needle (152) for penetrating the skin of the patient, the needle (152) having a lumen and selectively communicating with the reservoir (160). The device also includes a pressurizing system (600, 140) for selectively pressurizing the reservoir (160). In a pre-activated position, the pressurizing system (600, 140) contacts and compresses the reservoir (160) to reduce the initial volume of the reservoir (160), thereby allowing for partial filling of the reservoir (160).Type: GrantFiled: January 4, 2019Date of Patent: April 6, 2021Assignee: Becton, Dickinson and CompanyInventors: Lionel Vedrine, Ralph Sonderegger, Curt Bingham
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Publication number: 20200330679Abstract: The subject invention provides a drug delivery device for injecting medicament which includes a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.Type: ApplicationFiled: June 30, 2020Publication date: October 22, 2020Applicant: Becton, Dickinson and CompanyInventors: Richard A. Cronenberg, Lionel Vedrine, Paul Alchas