Abstract: The present disclosure relates to a technical field of chiral compound synthesis, and particularly to chiral or racemic pyrimidine-fused diazepinone derivatives, preparation method, and application thereof. A structural formula of the chiral or racemic pyrimidine-fused diazepinone derivatives or pharmaceutically acceptable salts thereof is as shown in formula (I), The present disclosure further provides a preparation method of the chiral or racemic pyrimidine-fused diazepinone derivatives, the method includes using pyrimidine allyl compound intermediates as raw materials, using iridium complexes formed by an interaction between iridium compounds and phosphoramidite ligands as catalysts, and obtaining the chiral or racemic pyrimidine-fused diazepinone derivatives by reactions under action of alkalis.

Abstract: A vertical-cavity surface-emitting laser (VCSEL) device includes a substrate, first and second-type doped distributed Bragg reflectors, first and second electrodes, an active layer, a surface relief layer having a surface relief indentation of a diameter (d4) ranging from 1.0-6.0 um, and a confinement member defining an aperture with a diameter (d2) ranging from 3.0-15 ?m. The second electrode is a ring-shaped p-contact metal having an inner diameter (d3) ranging from 8-17 ?m. The VCSEL device has a mesa structure that has a bottom mesa diameter (d1) ranging from 16-28 ?m. The diameters satisfy the relation of d1>d2>d3>d4. The surface relief layer has a thickness equaling to n/4 times a wavelength of a laser beam generated by the active layer with n being positive even numbers.

Abstract: A vertical-cavity surface-emitting laser (VCSEL) device includes a substrate, first and second-type doped distributed Bragg reflectors, first and second electrodes, an active layer, a surface relief layer having a surface relief indentation of a diameter (d4) ranging from 1.0-6.0 um, and a confinement member defining an aperture with a diameter (d2) ranging from 3.0-15 ?m. The second electrode is a ring-shaped p-contact metal having an inner diameter (d3) ranging from 8-17 ?m. The VCSEL device has a mesa structure that has a bottom mesa diameter (d1) ranging from 16-28 ?m. The diameters satisfy the relation of d1>d2>d3>d4. The surface relief layer has a thickness equaling to n/4 times a wavelength of a laser beam generated by the active layer with n being positive even numbers.

Abstract: The present invention provides compounds of the formula wherein R is optionally substituted lower alkyl, cycloalkyl or aryl; R? is alkyl or aryl; n is zero or an integer of 1 or 2; or an enantiomer thereof; or an enantiomeric mixture thereof. The compounds of formula (I) are bridged C2-symmetric biphenyldiphosphine analogs and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions. The compounds of the present invention are easily accessible in high diastereomeric and optical purity according to the methods disclosed herein.

Abstract: The present invention provides compounds of the formula wherein R is optionally substituted lower alkyl, cycloalkyl or aryl; R? is alkyl or aryl; n is zero or an integer of 1 or 2; or an enantiomer thereof; or an enantiomeric mixture thereof. The compounds of formula (I) are bridged C2-symmetric biphenyldiphosphine analogs and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions. The compounds of the present invention are easily accessible in high diastereomeric and optical purity according to the methods disclosed herein.