Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: An device for transporting an injured or disabled person from a building in an emergency situation including a source of pressurized fluid, such as a compressed air canister or cartridge, and an inflatable stretcher connected to the pressurized fluid source. The inflatable stretcher includes one or more handles to allow someone assisting the injured or handicapped person down a stairwell of the building. The stretcher includes means for securing the person to the stretcher, and further include air pockets configured to support, secure and cushion the injured or disabled person.