Patents by Inventor Lisa B. Dreisbach

Lisa B. Dreisbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydrophobic attachment site for adhesion peptides
    Patent number: 5760176
    Abstract: The invention provides a method of attaching peptides containing a biologically active site, for example RGD-containing adhesion peptides, to a solid surface through a hydrophobic domain, and peptides so attached. The hydrophobic domain can contain either hydrophobic amino acids, such as leucine, valine, isoleucine or phenylalanine, or fatty acids, such as, for example, myristic acid, palmitic acid, arachidic acid or other fatty acids. Additionally, spacers, such as amino acids, between the hydrophobic domain and the biologically active domain can improve the presentation of the biologically active site. Specific peptides of the invention includeGRGDSPASSKG.sub.4 RL.sub.6 RNH.sub.2 ;GRGDSPASSKS.sub.3 RL.sub.6 RNH.sub.2 ; andGRGDSPASSKSSKRL.sub.6 RNH.sub.2.
    Type: Grant
    Filed: October 10, 1996
    Date of Patent: June 2, 1998
    Assignee: La Jolla Cancer Research Foundation
    Inventors: Michael D. Pierschbacher, Cyril J. Honsik, Lisa B. Dreisbach
  • Hydrophobic attachment site for adhesion peptides
    Patent number: 5591822
    Abstract: The invention provides a method of attaching peptides containing a biologically active site, for example RGD-containing adhesion peptides, to a solid surface through a hydrophobic domain, and peptides so attached. The hydrophobic domain can contain either hydrophobic amino acids, such as leucine, valine, isoleucine or phenylalanine, or fatty acids, such as, for example, myristic acid, palmitic acid, arachidic acid or other fatty acids. Additionally, spacers, such as amino acids, between the hydrophobic domain and the biologically active domain can improve the presentation of the biologically active site. Specific peptides of the invention includeGRGDSPASSKG.sub.4 RL.sub.6 RNH.sub.2 ;GRGDSPASSKS.sub.3 RL.sub.6 RNH.sub.2 ; andGRGDSPASSKSSKRL.sub.6 RNH.sub.2.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: January 7, 1997
    Assignee: La Jolla Cancer Research Foundation
    Inventors: Michael D. Pierschbacher, Cyril J. Honsik, Lisa B. Dreisbach
  • Hydrophobic attachment site for adhesion peptides
    Patent number: 5587456
    Abstract: The invention provides a method of attaching peptides containing a biologically active site, for example RGD-containing adhesion peptides, to a solid surface through a hydrophobic domain, and peptides so attached. The hydrophobic domain can contain either hydrophobic amino acids, such as leucine, valine, isoleucine or phenylalanine, or fatty acids, such as, for example, myristic acid, palmitic acid, arachidic acid or other fatty acids. Additionally, spacers, such as amino acids, between the hydrophobic domain and the biologically active domain can improve the presentation of the biologically active site. Specific peptides of the invention includeGRGDSPASSKG.sub.4 RL.sub.6 RNH.sub.2 ;GRGDSPASSKS.sub.3 RL.sub.6 RNH.sub.2 ; andGRGDSPASSKSSKRL.sub.6 RNH.sub.2.
    Type: Grant
    Filed: August 20, 1992
    Date of Patent: December 24, 1996
    Assignee: La Jolla Cancer Research Foundation
    Inventors: Michael D. Pierschbacher, Cyril J. Honsik, Lisa B. Dreisbach
  • Hydrophobic attachment site for adhesion peptides
    Patent number: 5120829
    Abstract: The invention provides a method of attaching peptides containing a biologically active site, for example RGD-containing adhesion peptides, to a solid surface through a hydrophobic domain, and peptides so attached. The hydrophobic domain can contain either hydrophobic amino acids, such as leucine, valine, isoleucine or phenylalanine, or fatty acids, such as, for example, myristic acid, palmitic acid, arachidic acid or other fatty acids. Additionally, spacers, such as amino acids, between the hydrophobic domain and the biologically active domain can improve the presentation of the biologically active site. Specific peptides of the invention includeGRGDSPASSKG.sub.4 RL.sub.6 RNH.sub.2 ;GRGDSPASSKS.sub.3 RL.sub.6 RNH.sub.2 ;andGRGDSPASSKSSKRL.sub.6 RNH.sub.2.
    Type: Grant
    Filed: March 20, 1989
    Date of Patent: June 9, 1992
    Assignee: La Jolla Cancer Research Foundation
    Inventors: Michael D. Pierschbacher, Cyril J. Honsik, Lisa B. Dreisbach