Patents by Inventor Lisa B. Shih

Lisa B. Shih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnostic and therapeutic antibody conjugates
    Patent number: 5057313
    Abstract: The present invention relates to conjugates of diagnostic or therapeutic principles, such as drugs, toxins, chelators, boron compounds and detectable labels, to an antibody, in which the diagnostic or therapeutic principle is first loaded onto a polymer carrier such as an aminodextran or a polypeptide of at least 50 amino acids in length, and this intermediate is in turn site-specifically conjugated to a targeting antibody such as an antitumor antibody. The resultant conjugate substantially retains the immunoreactivity of the antibody, and targets the diagnostic or therapeutic principle to a target tissue or organ where the diagnostic or therapeutic effect is realized.
    Type: Grant
    Filed: August 23, 1988
    Date of Patent: October 15, 1991
    Assignee: The Center for Molecular Medicine and Immunology
    Inventors: Lisa B. Shih, Frederick J. Primus, Milton D. Goldenberg
  • Tumoricidal methotrexate-antibody conjugate
    Patent number: 4699784
    Abstract: A conjugate of methotrexate to an antibody is prepared by loading methotrexate onto an aminodextran, then specifically conjugating the polymer carrier to the carbohydrate portion of an antitumor antibody, using a reduced Schiff base linkage. The conjugate is useful for tumor targeted therapy.
    Type: Grant
    Filed: February 25, 1986
    Date of Patent: October 13, 1987
    Assignee: Center for Molecular Medicine & Immunology
    Inventors: Lisa B. Shih, Frederick J. Primus, Milton D. Goldenberg