Abstract: The present invention provides methods for enhancing the efficacy and/or safety of a vaccine. In certain embodiments, the invention provides methods to increase or potentiate the immune response to a vaccine in a subject in need thereof. The methods of the present invention comprise administering to a subject in need thereof an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody in combination with said vaccine. In certain embodiments, the methods of the present invention are used to afford enhanced protection to an infectious disease such as whooping cough.

Abstract: A motorized bicycle drive system featuring a motor drive with a one-way clutch, a pedal drive with a one-way clutch and a motor driveable sprocket, a removable interconnecting drive chain for interconnecting the two drives, and, a mounting device for detachably mounting the motor drive to a bicycle, whereby a motorized bicycle drive system can be compact, inconspicuous and easily removed from and remounted to a bicycle.