Patents by Inventor Lisheng Cai

Lisheng Cai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NR2B LIGANDS; METHOD OF MAKING; AND USE THEREOF
    Publication number: 20210094920
    Abstract: Disclosed herein are derivatives of 7-methoxy-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ol, including radiolabeled derivatives, which are found to be NR2B receptor subunit ligands. Pharmaceutical compositions comprising the derivative compounds and methods of treating schizophrenia, depression, stroke, or a neurodegenerative disease in a subject are also disclosed.
    Type: Application
    Filed: April 26, 2019
    Publication date: April 1, 2021
    Inventors: Lisheng Cai, Victor W. Pike, Robert B. INNIS
  • BETA-AMYLOID IMAGING AGENTS, METHODS OF MANUFACTURE, AND METHODS OF USE THEREOF
    Publication number: 20140348748
    Abstract: Derivatives of benzothiazolylbenzeneamines useful as imaging agents for nuclear imaging such as positron emission tomography of beta-amyloids are described. Methods of detecting amyloid using the compounds are described. Also disclosed is a radiolabeling method for selected compounds.
    Type: Application
    Filed: September 13, 2012
    Publication date: November 27, 2014
    Inventors: Lisheng Cai, Victor W. Pike
  • BETA-AMYLOID PET IMAGING AGENTS
    Publication number: 20140341812
    Abstract: Novel derivatives of imidazopyridinylbenzeneamines and novel derivatives of benzothiazolylbenzeneamines are disclosed that offer improved behavior when used as imaging agents for positron emission tomography of beta-amyloids. Also disclosed is a palladium-catalyzed reaction scheme under microwave conditions for aryl thioethers in general that provides a high ratio of substitution relative to reduction and can be used for the imidazopyridinylbenzeneamine derivatives as well as other compounds of related structure.
    Type: Application
    Filed: March 24, 2014
    Publication date: November 20, 2014
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Lisheng Cai, Victor W. Pike, Robert B. Innis
  • Beta-amyloid PET imaging agents
    Patent number: 8703096
    Abstract: Novel derivatives of imidazopyridinylbenzeneamines and novel derivatives of benzothiazolylbenzeneamines are disclosed that offer improved behavior when used as imaging agents for positron emission tomography of beta-amyloids. Also disclosed is a palladium-catalyzed reaction scheme under microwave conditions for aryl thioethers in general that provides a high ratio of substitution relative to reduction and can be used for the imidazopyridinylbenzeneamine derivatives as well as other compounds of related structure.
    Type: Grant
    Filed: April 19, 2007
    Date of Patent: April 22, 2014
    Assignee: The United States of America as Represented by the Secretary of the Department of Health and Human Services
    Inventors: Lisheng Cai, Victor W. Pike, Robert B. Innis
  • BETA-AMYLOID PET IMAGING AGENTS
    Publication number: 20110008255
    Abstract: Novel derivatives of imidazopyridinylbenzeneamines and novel derivatives of benzothiazolylbenzeneamines are disclosed that offer improved behavior when used as imaging agents for positron emission tomography of beta-amyloids. Also disclosed is a palladium-catalyzed reaction scheme under microwave conditions for aryl thioethers in general that provides a high ratio of substitution relative to reduction and can be used for the imidazopyridinylbenzeneamine derivatives as well as other compounds of related structure.
    Type: Application
    Filed: April 19, 2007
    Publication date: January 13, 2011
    Applicant: THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Lisheng Cai, Victor W. Pike, Robert B. Innis