Abstract: Antimicrobial and biofilm-inhibiting nitric oxide-releasing medical appliances for installation into a patient, and processes for producing the medical appliances. The medical appliances are configured for conveying materials into and out of the patient's body and may comprise tubings or pouching systems. The medical appliances comprise a gas-permeable cured resin material selected from the group consisting of curable silicones, polyvinyl acetates, thermoplastic elastomers, acrylonitrile-butadiene-styrene copolymer rubber, polyurethanes and selected combinations thereof, wherein the gas-permeable cured resin material comprises a matrix suitable for releasably sequestering therein permeating gases. A plurality of nitric-oxide gas-releasing moieties is sequestered within and through the gas-permeable resin material. Nitric oxide is released from at least a portion of said plurality of nitric oxide gas-releasing moieties upon contact of the medical appliance with a moisture source.