Abstract: A strong FXR small-molecule agonist, and a preparation method therefor and use thereof, the structure of the agonist being represented by formula (I), are provided. In the formula, each substituent is as defined in the description and the claims. The compound provided has the advantages of high FXR agonist activity, simple synthesis, easily available raw materials and the like, and can be used for preparing medicines for treating FXR related diseases.

Abstract: An FXR small molecule agonist and a preparation method therefor and a use thereof, having a structure as shown in formula (I). The compound represented by formula (I) has FXR agonistic activity and is capable of preparing drugs for treatment of FXR-related diseases.

Abstract: An information processing method and an electronic device are provided. The method includes: detecting a first physiological parameter of a user; obtaining a change in the first physiological parameter of the user based on the first physiological parameter of the user; controlling, based on the change in the first physiological parameter of the user, an image outputting unit to output the adjusted image information; determining an audio adjustment parameter for an audio outputting unit based on the change in the first physiological parameter; and adjusting output power of the audio outputting unit based on the audio adjustment parameter, and controlling the audio outputting unit to output audio information at the adjusted output power, so that the outputted audio information coincides with the outputted adjusted image information.

Abstract: The present disclosure provides an information processing method and an electronic device. The method comprises: obtaining an audio signal in an output signal; determining N channel signals in the audio signal, where N is a positive integer; determining whether the audio signal needs to be adjusted or not; and adjusting, when the audio signal needs to be adjusted, an output parameter of at least one of the N channel signals respectively, and outputting the N adjusted channel signals via an audio output device, such that the N adjusted channel signals correspond to a sound source position of the audio signal. The above method according to the present disclosure can solve the technical problem that the audio signal cannot be adjusted in real time and achieve a technical effect of automatic adjustment of the audio signal.

Abstract: An information processing method and an electronic device are provided. The method includes: detecting a first physiological parameter of a user; obtaining a change in the first physiological parameter of the user based on the first physiological parameter of the user; controlling, based on the change in the first physiological parameter of the user, an image outputting unit to output the adjusted image information; determining an audio adjustment parameter for an audio outputting unit based on the change in the first physiological parameter; and adjusting output power of the audio outputting unit based on the audio adjustment parameter, and controlling the audio outputting unit to output audio information at the adjusted output power, so that the outputted audio information coincides with the outputted adjusted image information.

Abstract: The present disclosure provides an information processing method and an electronic device. The method comprises: obtaining an audio signal in an output signal; determining N channel signals in the audio signal, where N is a positive integer; determining whether the audio signal needs to be adjusted or not; and adjusting, when the audio signal needs to be adjusted, an output parameter of at least one of the N channel signals respectively, and outputting the N adjusted channel signals via an audio output device, such that the N adjusted channel signals correspond to a sound source position of the audio signal. The above method according to the present disclosure can solve the technical problem that the audio signal cannot be adjusted in real time and achieve a technical effect of automatic adjustment of the audio signal.

Abstract: The present disclosure discloses an ?-alumina carrier, comprising the elements of lanthanum and silicon both dispersed in the interior and on the surface of the carrier. The mass ratio of the element of lanthanum to the element of silicon is in the range from 0.1:1 to 20:1. The inventors of the present disclosure have made extensive researches into the field of the silver catalyst and alumina carrier thereof, and added the elements of lanthanum and silicon (i.e., bulk phase addition) in preparing the alumina carrier used in the silver catalyst. The carrier thus obtained contains the elements of silicon and lanthanum both in the interior and on the surface thereof, and has improved specific surface area and strength. The silver catalyst prepared with the carrier can react in a low reaction temperature (has a high reaction activity) and has a high selectivity in producing ethylene oxide through oxidation of ethylene.

Abstract: The present disclosure discloses an ?-alumina carrier, comprising the elements of lanthanum and silicon both dispersed in the interior and on the surface of the carrier. The mass ratio of the element of lanthanum to the element of silicon is in the range from 0.1:1 to 20:1. The inventors of the present disclosure have made extensive researches into the field of the silver catalyst and alumina carrier thereof, and added the elements of lanthanum and silicon (i.e., bulk phase addition) in preparing the alumina carrier used in the silver catalyst. The carrier thus obtained contains the elements of silicon and lanthanum both in the interior and on the surface thereof, and has improved specific surface area and strength. The silver catalyst prepared with the carrier can react in a low reaction temperature (has a high reaction activity) and has a high selectivity in producing ethylene oxide through oxidation of ethylene.

Abstract: The present invention relates to a method of detecting invalid border gateway protocol (BGP) route in a network, wherein network traffic is routed based at least on BGP announcements from one or more BGP routers, the method comprising obtaining a plurality of routing information objects from the BGP announcements during an observation window, each routing information object comprising at least one selected from a group consisting of an prefix-origin autonomous system (AS) association and a directed AS-link, identifying a transient routing information object having at least one selected from a group consisting of a up time less than a first pre-determined threshold or a lifespan less than a second pre-determined threshold, defining a valid routing information object set by eliminating the transient routing information object from the plurality of routing information objects, and detecting a BGP route from the BGP announcements as invalid based on the valid routing information object set.

Abstract: A system and method for detecting and diagnosing routing problems in a network in real-time by recording TCP flow information from at least one server to at least one prefix, and observing retransmission packets communicated from the at least one server to the at least one prefix. When a predetermined threshold for TCP flows to a prefix is reached, traceroutes may be triggered to a destination in the prefix, and the traceroutes analyzed to determine whether to issue an alarm for a routing failure. The system includes a real-time data collection engine for recording unidirectional TCP flow information, a real-time detection engine for observing the retransmission packets and issuing a warning upon a retransmission counter exceeding a predetermined threshold, and a real-time diagnosis engine for triggering at least one traceroute to a destination in the prefix that is randomly selected from TCP flows in retransmission states.

Abstract: The invention relates to a method for generating a prefix hijacking alert in a network, wherein a plurality of network traffic flows are routed based at least on a plurality of prefix announcements from one or more Border Gateway Protocol (BGP) router, the method comprises identifying an anomalous prefix from the plurality of prefix announcements, identifying a network traffic anomaly from the plurality of network traffic flows, and correlating the anomalous prefix and the network traffic anomaly to generate the prefix hijacking alert.