Patents by Inventor Lloyd G. Czaplewski

Lloyd G. Czaplewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fibrinolytic and anti-thrombotic cleavable dimers
    Patent number: 5434073
    Abstract: Relatively inactive fusion proteins are activatable by enzymes of the clotting cascade to have fibrinolytic and/or clot formation inhibition activity. For example, a fusion protein comprising two hirudin or streptokinase molecules, linked by a cleavable linkage sequence, may be cleaved to yield anti-thrombotic hirudin or fibrinolytic streptokinase by thrombin or Factor Xa. Fibrinolytic or clot formation inhibition activity is therefore directed to the site of clot formation. Cleavable streptokinase/hirudin heterodimers are claimed.
    Type: Grant
    Filed: June 3, 1992
    Date of Patent: July 18, 1995
    Assignee: British Bio-Technology Limited
    Inventors: Keith Dawson, Michael G. Hunter, Lloyd G. Czaplewski