Patents by Inventor Lloyd M. Garrick

Lloyd M. Garrick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Acylresorcinol derivatives are selective vitronectin receptor inhibitors
    Publication number: 20030186967
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: February 6, 2002
    Publication date: October 2, 2003
    Applicant: American Home Products Corporation
    Inventors: Kenneth Lewis Kees, Lloyd M. Garrick, Ariamala Gopalsamy
  • Substituted quinazolines as angiotensin II antagonists
    Patent number: 5256781
    Abstract: There are disclosed compounds of the general formula I: ##STR1## wherein A is O, S, NR.sup.6, --CR.sup.7 .dbd.CR.sup.8 --;Z is O, S, NR.sup.6, --CR.sup.7 .dbd.CR.sup.8 --;X is H, NR.sup.9 R.sup.10, OR.sup.11, CN, F, Cl, I, Br, perfluoroalkyl, alkyl, alkoxy, alkyl-OH, alkoxyalkyl, --(CH.sub.2).sub.n CO.sub.2 R.sup.11, --(CH.sub.2).sub.n CONR.sup.9 R.sup.10 ;when Z=--CR.sup.7 .dbd.CR.sup.8 -- then Y is NR.sup.13, NR.sup.13 CR.sup.12 R.sup.14 ; CR.sup.12 R.sup.14 NR.sup.13 ;when Z.dbd.O, S, NR.sup.6 then Y is NR.sup.13 CR.sup.12 R.sup.14 ;R.sup.1 is 5-tetrazolyl, CO.sub.2 R.sup.11, SO.sub.3 H, NHSO.sub.2 CH.sub.3, NHSO.sub.2 CF.sub.3 ;R.sup.2, R.sup.3, R.sup.4, R.sup.7, R.sup.8 is H, alkyl, alkoxy, alkoxyalkyl, alkyl-OH, perfluoroalkyl, aralkyl, CN, NO.sub.2, SO.sub.2 R.sup.13, --(CH.sub.2).sub.n CO.sub.2 R.sup.11, --(CH.sub.2).sub.n CONR.sup.9 R.sup.10, OR.sup.11, F, Cl, Br, I, NR.sup.9 R.sup.10 ;R.sup.5 is alkyl, alkoxy, alkoxyalkyl, alkyl-OH, perfluoroalkyl, aralkyl, H, --CN, NO.sub.2, SO.sub.2 R.sup.
    Type: Grant
    Filed: March 22, 1993
    Date of Patent: October 26, 1993
    Assignee: American Home Products Corporation
    Inventors: John L. Primeau, Lloyd M. Garrick
  • Fused pyrimidines as angiotensin II antagonists
    Patent number: 5236925
    Abstract: There are disclosed compounds of the general formula I: ##STR1## wherein A is O, S, NR.sup.6 ;Z is O, S, NR.sup.6 ;X is H, NR.sup.9 R.sup.10, OR.sup.11, CN, F, Cl, I, Br, perfluoroalkyl, alkyl, alkyl-OH, alkoxyalkyl, --(CH.sub.2).sub.n CO.sub.2 R.sup.11, --(CH.sub.2).sub.n CONR.sup.9 R.sup.10 ;Y is NR.sup.13 CR.sup.12 R.sup.14 ;R.sup.1 is 5-tetrazolyl, CO.sub.2 R.sup.11, SO.sub.3 H, NHSO.sub.2 CH.sub.3, NHSO.sub.2 CF.sub.3 ;R.sup.2, R.sup.3, R.sup.4, R.sup.7, R.sup.8 is H, alkyl, alkoxyalkyl, alkyl-OH, perfluoroalkyl, aralkyl, CN, NO.sub.2, SO.sub.2 R.sup.13, --(CH.sub.2).sub.n CO.sub.2 R.sup.11, --(CH.sub.2).sub.n CONR.sup.9 R.sup.10, OR.sup.11, F, Cl, Br, I, NR.sup.9 R.sup.10 ;R.sup.5 is alkyl, alkoxyalkyl, alkyl-OH, perfluoroalkyl, aralkyl, H, --CN, NO.sub.2, SO.sub.2 R.sup.13, --(CH.sub.2).sub.n CO.sub.2 R.sup.11, --(CH.sub.2).sub.n CONR.sup.9 R.sup.10 ;R.sup.6 is H, alkyl, aralkyl;R.sup.9, R.sup.10 is H, alkyl, alkoxyalkyl, alkyl-OH, perfluoroalkyl, aralkyl;R.sup.11 is H, alkyl, aralkyl, alkoxyalkyl;R.
    Type: Grant
    Filed: August 6, 1992
    Date of Patent: August 17, 1993
    Assignee: American Home Products Corporation
    Inventors: John L. Primeau, Lloyd M. Garrick
  • Pyrimidocycloalkanes as a II antagonists
    Patent number: 5234936
    Abstract: There are disclosed compounds of the general formula I: ##STR1## wherein X is H, NR.sup.12 R.sup.13, OR.sup.14, CN, F, Cl, I, Br, perfluoroalkyl, alkyl, alkoxy, alkyl-OH, alkoxyalkyl, --(CH.sub.2).sub.n CO.sub.2 R.sup.14, --(CH.sub.2).sub.n CONR.sup.12 R.sup.13 ;Y is NR.sup.15, NR.sup.18 CR.sup.16 R.sup.17, CR.sup.16 R.sup.17 NR.sup.15 ;R.sup.1 is 5-tetrazolyl, CO.sub.2 R.sup.14, SO.sub.3 H, NHSO.sub.2 CH.sub.3, NHSO.sub.2 CF.sub.3 ;R.sup.2, R.sup.3 is H, alkyl, alkoxy, alkoxyalkyl, alkyl-OH perfluoroalkyl, aralkyl, CN, NO.sub.2, SO.sub.2 R.sup.19, --(CH.sub.2).sub.n CO.sub.2 R.sup.14, --(CH.sub.2).sub.n CONR.sup.12 R.sup.13, OR.sup.14, F, Cl, Br, I, NR.sup.12 R.sup.13 ;R.sup.4 -R.sup.11 is H, F, alkyl, alkoxy, alkoxyalkyl, --OCOR.sup.14, alkyl-OH, perfluoroalkyl, aralkyl, aryl, CN, NO.sub.2, SO.sub.2 R.sup.19, --(CH.sub.2).sub.n CO.sub.2 R.sup.14, --(CH.sub.2).sub.n CONR.sup.12 R.sup.13, OH, OR.sup.14, --NR.sup.12 R.sup.13, any two geminal groups can be O or CH.sub.2 ;R.sup.12, R.sup.
    Type: Grant
    Filed: October 24, 1991
    Date of Patent: August 10, 1993
    Assignee: American Home Products Corporation
    Inventors: John L. Primeau, Lloyd M. Garrick, Timothy D. Ocain, Richard M. Soll, Paul J. Dollings
  • Substituted quinazolines as angiotensin II antagonists
    Patent number: 5187168
    Abstract: There are disclosed compounds of the general formula I: ##STR1## wherein A is --CR.sup.7 .dbd.CR.sup.8 --;Z is --CR.sup.7 .dbd.CR.sup.8 --;X is H, NR .sup.9 R.sup.10, OR.sup.11, CN, F, Cl, I, Br, perfluoroalkyl, alkyl,alkoxy, alkyl-OH, alkoxyalkyl, --(CH.sub.2).sub.n CO.sub.2 R.sup.11,--(CH.sub.2).sub.n CONR.sup.9 R.sup.10 ;Y is NR.sup.13,NR.sup.13 CR.sup.12 R.sup.14, CR.sup.12 R.sup.14 NR.sup.13 ;R.sup.1 is 5-tetrazolyl, CO.sub.2 R.sup.11,SO.sub.3 H, NHSO.sub.2 CH.sub.3, NHSO.sub.2 CF.sub.3 ;R.sup.2,R.sup.3,R.sup.4,R.sup.7 R.sup.8 is H, alkyl, alkoxy, alkoxyalkyl, alkyl-OH, perfluoroalkyl, aralkyl, CN, NO.sub.2, SO.sub.2 R.sup.13, --(CH.sub.2).sub.n CO.sub.2 R.sup.11,--(CH.sub.2).sub.n CONR.sup.9 R.sup.10, OR.sup.11,F,Cl,Br,I,NR.sup.9 R.sup.10 ;R.sup.5 is alkyl, alkoxy, alkoxyalkyl, alkyl-OH, perfluoroalkyl, aralkyl, H, --CN, NO.sub.2, SO.sub.2 R.sup.13,--(CH.sub.2).sub.n CO.sub.2 R.sup.11, --(CH.sub.2).sub.n CONR.sup.9 R.sup.10, --OH,OR.sup.11,F,Cl,Br,I,NR.sup.9 R.sup.10 ;R.sup.9,R.sup.
    Type: Grant
    Filed: October 24, 1991
    Date of Patent: February 16, 1993
    Assignee: American Home Products Corporation
    Inventors: John L. Primeau, Lloyd M. Garrick