Patents by Inventor Logeeshan VELMANICKAM

Logeeshan VELMANICKAM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DEVICE FOR MANUFACTURE OF T-CELLS FOR AUTOLOGOUS CELL THERAPY
    Publication number: 20220266214
    Abstract: The present invention relates to a device for a scalable biomanufacturing platform for the production of modified cells such as CAR-modified T-cells while eliminating on-target/off-tumor toxicity and decreasing the current production cost by 500 times (per treatment), and to attendant methods. The includes a first chamber for proliferating a population of cells and a second chamber for modifying the cells to express a desired T-cell receptor antigen.
    Type: Application
    Filed: March 2, 2022
    Publication date: August 25, 2022
    Inventors: Dharmakeerthi NAWARATHNA, Logeeshan VELMANICKAM, Vidura JAYASOORIYA
  • Integrated dielectrophoretic and surface plasmonic apparatus and methods for improvement in the detection of biological molecules
    Patent number: 10794894
    Abstract: The present invention relates to an apparatus and methods for an integrated dielectrophoretic (DEP) and surface plasmonic platform to quantify as little as 1 femptomolar to 1 picomolar of fluorescent molecules in low conductivity buffers.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: October 6, 2020
    Assignee: NDSU Research Foundation
    Inventors: Dharmakeerthi Nawarathna, Logeeshan Velmanickam
  • METHOD FOR DETECTING ANALYTES USING DIELECTROPHORESIS RELATED APPLICATIONS
    Publication number: 20190234902
    Abstract: A system for determining an effect of a non-uniform electric field on a dielectric particle includes a pair of electrodes for generating the non-uniform electric field, a function generator in communication with a computer and the electrodes for changing the frequency of the electric field, and a camera in communication with a microscope and the computer for capturing a series of images of the dielectric particle in the non-uniform electric field. The computer is programmed to detect changes between the images in the series of images to determine the effect of the non-uniform electric field on the dielectric particle.
    Type: Application
    Filed: January 28, 2019
    Publication date: August 1, 2019
    Inventors: Ivan T. Lima, Jr., Darmakeerthi Nawarantha, Fleming Dackson Gudagunti, Logeeshan Velmanickam
  • DEVICE FOR MANUFACTURE OF T-CELLS FOR AUTOLOGOUS CELL THERAPY
    Publication number: 20190177679
    Abstract: The present invention relates to a new device for a scalable, biomanufacturing platform for the production of CAR-modified T-cells while eliminating on-target/off-tumor toxicity and decreasing the current production cost by 500 times (per treatment). The invention relates to a device to produce modified T-cells comprising a first chamber for proliferating a population of T-cells and a second chamber for modifying the T-cells to express a desired T-cell receptor antigen.
    Type: Application
    Filed: September 7, 2017
    Publication date: June 13, 2019
    Inventors: Dharmakeerthi NAWARTHNA, Logeeshan VELMANICKAM, Vidura JAYASOORIYA
  • INTEGRATED DIELECTROPHORETIC AND SURFACE PLASMONIC APPARATUS AND METHODS FOR IMPROVEMENT IN THE DETECTION OF BIOLOGICAL MOLECULES
    Publication number: 20190064139
    Abstract: The present invention relates to an apparatus and methods for an integrated dielectrophoretic (DEP) and surface plasmonic platform to quantify as little as 1 femptomolar to 1 picomolar of fluorescent molecules in low conductivity buffers.
    Type: Application
    Filed: August 22, 2018
    Publication date: February 28, 2019
    Inventors: Keerthi NAWARATHNA, Logeeshan VELMANICKAM