Abstract: The presently disclosed subject matter provides chimeric antigen receptors (CARs) that specifically target CD19 and cells comprising such CD19-targeted CARs. The presently disclosed subject matter further provides uses of the CD19-targeted CARs for treatment, e.g., for treating blood cancer.

Abstract: The invention relates to a ring seal which comprises a main body capable of implementing a seal by static contact relative to a first cylindrical element, and a first circumferential lip capable of engaging by friction with a cylindrical surface of a second cylindrical element, said cylindrical elements being substantially coaxial and mounted so as to pivot relative to one another. The main body comprises a front surface configured to be in axial contact with a front surface of the first cylindrical element, the main body comprising a second circumferential lip radially opposite the first circumferential lip and capable of being in radial contact with a cylindrical surface of the first cylindrical element.

Abstract: Sealing device for a propeller shaft of a marine vehicle propulsion unit including a plurality of sealing lips axially offset relative to each other, with a receiving space for a hydraulic fluid delimited by two adjacent sealing lips, at least one buffer space axially offset with respect to the receiving space and delimited by two adjacent sealing lips, whereby the sealing device includes suitable feeding means for supplying the buffer space with a buffer fluid. The device includes a sampling circuit able to sample fluid included in the buffer space and a monitoring device able to check parameters of the fluid sampled by the sampling circuit.

Abstract: The invention relates to a method for determining the direction and the amplitude of a force applied to a system (IO) comprising a stationary portion (13) and a mobile portion (12) which can deform when exposed to said force. Mechanical deformations applied to the mobile portion when exposed to said force are measured by measuring a distance between the stationary portion and the mobile portion in the direction of application of the force, and the distance measurements are processed in order to determine the amplitude and the direction of the force.

Abstract: The invention relates to a ring seal which comprises a main body capable of implementing a seal by static contact relative to a first cylindrical element, and a first circumferential lip capable of engaging by friction with a cylindrical surface of a second cylindrical element, said cylindrical elements being substantially coaxial and mounted so as to pivot relative to one another. The main body comprises a front surface configured to be in axial contact with a front surface of the first cylindrical element, the main body comprising a second circumferential lip radially opposite the first circumferential lip and capable of being in radial contact with a cylindrical surface of the first cylindrical element.

Abstract: The drive unit is designed to be mounted on a marine vessel, including a mobile housing, and is able to pivot around an axis against the hull of the marine vessel. A drive shaft mounted rotary is against the mobile housing and is supported by two roller bearings. A propulsion element rotates in solidarity with the drive shaft. The propulsion unit has, at the front, at least two braking and locking systems of the drive shaft located in an area between the upstream rolling bearing and propulsion element.

Abstract: The drive unit is designed to be mounted on a marine vessel, including a mobile housing, and is able to pivot around an axis against the hull of the marine vessel. A drive shaft mounted rotary is against the mobile housing and is supported by two roller bearings. A propulsion element rotates in solidarity with the drive shaft. The propulsion unit has, at the front, at least two braking and locking systems of the drive shaft located in an area between the upstream rolling bearing and propulsion element.

Abstract: This propulsion unit for an aquatic vehicle consists of a mobile casing mounted in a pivot connection in relation to a hull element of the aquatic vehicle, a drive shaft of a propeller, said shaft being mounted rotatably within the mobile casing by means of at least one bearing consisting of a closed space adapted to be filled with a hydraulic fluid, an electrical machine being adapted to drive the rotary drive shaft in relation to the mobile casing, where the propulsion unit further consists of a module for conditioning the hydraulic fluid contained in the closed space of the bearing. The propulsion unit also consists of a control device to control the conditioning, the control device consisting of a temperature sensor and capable of activating the conditioning of the hydraulic fluid contained in the closed space according to the temperature measured by the temperature sensor.

Abstract: This propulsion unit for an aquatic vehicle consists of a mobile casing equipped with an azimuth bearing due to its mounting in a pivot connection in relation to a hull element of the aquatic vehicle, the azimuth bearing having a closed volume provided to contain a hydraulic fluid, the propulsion unit having a drive shaft of a propeller, said shaft being mounted rotatably within the mobile casing by means of at least one bearing having a closed space adapted to contain a hydraulic fluid, an electrical machine being adapted to drive the rotary drive shaft in relation to the mobile casing, the propulsion unit having a supply circuit adapted to supply the closed space of the shaft bearing with hydraulic fluid. The supply circuit has a supply duct connecting the closed space of the shaft bearing and the closed volume of the azimuth bearing.

Abstract: Sealing device for a propeller shaft of a marine vehicle propulsion unit including a plurality of sealing lips axially offset relative to each other, with a receiving space for a hydraulic fluid delimited by two adjacent sealing lips, at least one buffer space axially offset with respect to the receiving space and delimited by two adjacent sealing lips, whereby the sealing device includes suitable feeding means for supplying the buffer space with a buffer fluid. The device includes a sampling circuit able to sample fluid included in the buffer space and a monitoring device able to check parameters of the fluid sampled by the sampling circuit.

Abstract: This propulsion unit for an aquatic vehicle consists of a mobile casing equipped with an azimuth bearing due to its mounting in a pivot connection in relation to a hull element of the aquatic vehicle, the azimuth bearing having a closed volume provided to contain a hydraulic fluid, the propulsion unit having a drive shaft of a propeller, said shaft being mounted rotatably within the mobile casing by means of at least one bearing having a closed space adapted to contain a hydraulic fluid, an electrical machine being adapted to drive the rotary drive shaft in relation to the mobile casing, the propulsion unit having a supply circuit adapted to supply the closed space of the shaft bearing with hydraulic fluid. The supply circuit has a supply duct connecting the closed space of the shaft bearing and the closed volume of the azimuth bearing.

Abstract: This propulsion unit for an aquatic vehicle consists of a mobile casing mounted in a pivot connection in relation to a hull element of the aquatic vehicle, a drive shaft of a propeller, said shaft being mounted rotatably within the mobile casing by means of at least one bearing consisting of a closed space adapted to be filled with a hydraulic fluid, an electrical machine being adapted to drive the rotary drive shaft in relation to the mobile casing, where the propulsion unit further consists of a module for conditioning the hydraulic fluid contained in the closed space of the bearing. The propulsion unit also consists of a control device to control the conditioning, the control device consisting of a temperature sensor and capable of activating the conditioning of the hydraulic fluid contained in the closed space according to the temperature measured by the temperature sensor.

Abstract: The present invention provides methods of treating cancer by administering a compound of formula I, optionally as a pharmaceutically acceptable salt, solvate and/or hydrate thereof, in combination with an inhibitor that targets HER2 and/or HER3.

Abstract: The present invention relates to compositions comprising at least one MAPK pathway inhibitor including MEK and RAF inhibitors and at least one PI3K? inhibitor, and also to uses thereof for the treatment of cancer.

Abstract: The present invention provides methods of treating cancer by administering a compound of formula I, optionally as a pharmaceutically acceptable salt, solvate and/or hydrate thereof, in combination with an inhibitor that targets HER2 and/or HER3.

Abstract: Methods of treating patients with cancer are provided, wherein the methods comprise administering to the patient an effective amount of a MEK inhibitor and an effective amount of a PI3K inhibitor. Compositions in which the MEK and PI3K inhibitors are combined also are described.

Abstract: A keyless access system is provided for a truck including a tractor area and a cargo area provided with at least an access door. This system includes a main control unit located in the tractor area and adapted to interact with a customer identification device to selectively operate a control access arrangement which allows or prevents access to a driver cabin of the truck, a secondary control unit located in or near the cargo area and adapted to interact with the same customer identification device and to selectively operate an actuator which locks or unlocks the access door, and a bidirectional telecommunication arrangement between the main and secondary units.

Abstract: A vehicle unlocking sequence includes passively authenticating a vehicle user, granting the authenticated vehicle user access to the vehicle and setting the vehicle main switch into an on-state. A vehicle locking sequence includes passively authenticating the vehicle user, configuring the vehicle, upon a first action from the authenticated vehicle user, into a first locking mode whereby access to the vehicle is denied to a non authenticated user, or configuring the vehicle, upon a second action from the authenticated vehicle user, into a second locking mode whereby access to the vehicle is denied to a non authenticated user and the vehicle main switch is set into an off-state.

Abstract: The present invention relates to an isolated cell capable of fixing tumour cells, expressing the CD10 protein and expressing at least one MDR protein, and to the use of this cell for screening for anti-tumour compounds.

Abstract: A keyless access system is provided for a truck including a tractor area and a cargo area provided with at least an access door. This system includes a main control unit located in the tractor area and adapted to interact with a customer identification device to selectively operate a control access arrangement which allows or prevents access to a driver cabin of the truck, a secondary control unit located in or near the cargo area and adapted to interact with the same customer identification device and to selectively operate an actuator which locks or unlocks the access door, and a bidirectional telecommunication arrangement between the main and secondary units.