Patents by Inventor Lok Yan Fan

Lok Yan Fan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Live-attenuated virus and methods of production and use
    Patent number: 10793834
    Abstract: Presented herein are live-attenuated viruses and methods of generating thereof from a parental virus through a plurality of nucleotide substitutions in the viral genome. The nucleotide substitutions result in a change in codon usage bias within codons of one or more protein encoding sequences and no change in amino acid sequences of the proteins. The live-attenuated viruses display unaltered replication in avian hosts for propagation, but attenuated replication in mammalian hosts, when compared to the replication of the parental virus. The live-attenuated viruses in a form of improved vaccines can be used to elicit protective immune responses.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: October 6, 2020
    Assignee: THE UNIVERSITY OF HONG KONG
    Inventors: Lit Man Poon, Lok Yan Fan
  • LIVE-ATTENUATED VIRUS AND METHODS OF PRODUCTION AND USE
    Publication number: 20160354460
    Abstract: Presented herein are live-attenuated viruses and methods of generating thereof from a parental virus through a plurality of nucleotide substitutions in the viral genome. The nucleotide substitutions result in a change in codon usage bias within codons of one or more protein encoding sequences and no change in amino acid sequences of the proteins. The live-attenuated viruses display unaltered replication in avian hosts for propagation, but attenuated replication in mammalian hosts, when compared to the replication of the parental virus. The live-attenuated viruses in a form of improved vaccines can be used to elicit protective immune responses.
    Type: Application
    Filed: June 6, 2016
    Publication date: December 8, 2016
    Inventors: Lit Man Poon, Lok Yan Fan