Patents by Inventor Lone Jeppesen

Lone Jeppesen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-heteroaryl indole carboxamides and analogues thereof, for use as glcokinase activators in the treatment of diabetes
    Publication number: 20070027140
    Abstract: This invention relates to compounds that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial. The compounds are of the general formula (I) wherin A and B are further defined in the application.
    Type: Application
    Filed: May 24, 2006
    Publication date: February 1, 2007
    Applicant: Novo Nordisk A/S
    Inventors: Jesper Lau, Per Vedso, Janos Kodra, Anthony Murray, Lone Jeppesen, Michael Ankersen, Govindan Subramanian, Adnan Mjalli, Robert Andrews, Dharma Pollisetti, Daniel Christen
  • Novel compounds, their preparation and use
    Publication number: 20060287393
    Abstract: Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPAR? suptype.
    Type: Application
    Filed: May 23, 2006
    Publication date: December 21, 2006
    Applicant: Novo Nordisk A/S
    Inventors: Lone Jeppesen, Ingrid Pettersson, Per Sauerberg, Pavel Pihera, Miroslav Havranek
  • Peroxisome proliferator activated receptor-active arylene acetic acid derivatives
    Patent number: 7129268
    Abstract: Novel compounds of the general formula (I), wherein Ar, R1, R2, X1, X2, Y1, Y, and Z are as defined in the specification, the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPAR? subtype.
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: October 31, 2006
    Assignee: Novo Nordisk A/S
    Inventors: Lone Jeppesen, John Patrick Mogensen, Ingrid Pettersson, Per Sauerberg, Pavel Pihera, Miroslav Havranek
  • Aryl carbonyl derivatives as therapeutic agents
    Publication number: 20060183783
    Abstract: This invention relates to aryl carbonyl derivativeswhich are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
    Type: Application
    Filed: March 1, 2006
    Publication date: August 17, 2006
    Inventors: Dharma Polisetti, Janos Kodra, Jesper Lau, Paw Bloch, Maria Lopez, Niels Blume, Mustafa Guzel, Kalpathy Santhosh, Adnan Mjalli, Robert Andrews, Govindan Subramanian, Michael Ankersen, Per Vedso, Anthony Murray, Lone Jeppesen
  • Compounds, their preparation and use
    Patent number: 7091245
    Abstract: Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPAR? suptype.
    Type: Grant
    Filed: September 4, 2003
    Date of Patent: August 15, 2006
    Assignee: Novo Novdisk A/S
    Inventors: Lone Jeppesen, John Patrick Mogensen, Ingrid Pettersson, Per Sauerberg
  • Compounds, their preparation and use
    Patent number: 7067530
    Abstract: Novel compounds of general formula (I), the use of these compounds as medicaments, pharmaceuticaly compositions comprising the compounds and methods of treatment employing these compounds and compostiones. The present compounds may be useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR). The compounds exert their effects by modulating the PPAR? response in a partial agonist manner.
    Type: Grant
    Filed: July 29, 2002
    Date of Patent: June 27, 2006
    Assignee: Novo Nordisk A/S
    Inventors: Lone Jeppesen, Paul Stanley Bury, John Patrick Mogensen, Ingrid Pettersson, Per Sauerberg
  • Compounds, their preparation and use
    Patent number: 6972294
    Abstract: Disclosed are novel compounds of formula (I) wherein A1, A2, Ar, R5, R6, R8, M, Q, Y, Z, k, m and n are as defined in the specification. These compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR). Such conditions include diabetes and obesity.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: December 6, 2005
    Assignee: Novo Nordisk, A/S
    Inventors: Anthony Murray, Per Sauerberg, Lone Jeppesen, Ingrid Pettersson, Paul Stanley Bury
  • Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases)
    Publication number: 20050119332
    Abstract: The present invention provides novel compounds of formula 1a, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTP?, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.
    Type: Application
    Filed: November 8, 2004
    Publication date: June 2, 2005
    Inventors: Lone Jeppesen, Henrik Andersen, Ole Olsen, Luke Judge, Daniel Holsworth, Farid Bakir, Frank Axe, Yu Ge
  • Novel compounds, their preparation and use
    Publication number: 20050080115
    Abstract: Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPAR? suptype.
    Type: Application
    Filed: October 24, 2003
    Publication date: April 14, 2005
    Inventors: Lone Jeppesen, Ingrid Pettersson, Per Sauerberg, Pavel Pihera, Miroslav Havranek
  • Novel compounds, their preparation and use
    Publication number: 20050070583
    Abstract: Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPAR? suptype.
    Type: Application
    Filed: October 24, 2003
    Publication date: March 31, 2005
    Inventors: Lone Jeppesen, John Mogensen, Ingrid Pettersson, Per Sauerberg, Pavel Pihera, Miroslav Havranek
  • Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives
    Patent number: 6869967
    Abstract: Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPAR? suptype.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: March 22, 2005
    Assignee: Novo Nordisk A/S
    Inventors: Lone Jeppesen, Paul Stanley Bury, John Patrick Mogensen, Ingrid Pettersson, Per Sauerberg
  • Compounds, their preparation and use
    Patent number: 6867218
    Abstract: The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).
    Type: Grant
    Filed: February 20, 2003
    Date of Patent: March 15, 2005
    Assignee: Novo Nordisk A/S
    Inventors: John Patrick Mogensen, Per Sauerberg, Paul Stanley Bury, Lone Jeppesen, Ingrid Pettersson
  • Novel compounds, their preparation and use
    Publication number: 20040259950
    Abstract: A novel class of dicarboxylic acid derivatives, the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR).
    Type: Application
    Filed: December 12, 2003
    Publication date: December 23, 2004
    Inventors: Per Sauerberg, Lone Jeppesen, Zdenek Polivka, Karel Sindelar
  • Compounds useful in the treatment of conditions mediated by peroxisome proliferator-activated receptors (PPAR)
    Publication number: 20040229899
    Abstract: The present invention relates to compounds of formula (I) 1
    Type: Application
    Filed: January 6, 2004
    Publication date: November 18, 2004
    Inventors: Lone Jeppesen, Paul Stanley Bury, Per Sauerberg
  • Novel compounds, their preparation and use
    Publication number: 20040143006
    Abstract: Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPAR&dgr; suptype.
    Type: Application
    Filed: September 4, 2003
    Publication date: July 22, 2004
    Inventors: Lone Jeppesen, John Patrick Mogensen, Ingrid Pettersson, Per Sauerberg
  • Aryl carbonyl derivatives as therapeutic agents
    Publication number: 20040122235
    Abstract: This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
    Type: Application
    Filed: October 6, 2003
    Publication date: June 24, 2004
    Inventors: Dharma Rao Polisetti, Janos Tibor Kodra, Jesper Lau, Paw Bloch, Maria Carmen Valcarce-Lopez, Niels Blume, Mustafa Guzel, Kalpathy Chidambareswaran Santhosh, Adnan M.M. Mjalli, Robert Carl Andrews, Govindan Subramanian, Michael Ankersen, Per Vedso, Anthony Murray, Lone Jeppesen
  • Compounds useful in the treatment of conditions mediated by peroxisome proliferator-activated receptors (PPAR)
    Patent number: 6723731
    Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, Ar, X, Q, A, Y and Z are as defined in the specification. These compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: April 20, 2004
    Assignees: Novo Nordisk A/S, Dr. Reddy's Research Foundation
    Inventors: Lone Jeppesen, Paul Stanley Bury, Per Sauerberg
  • Heterocyclic compounds and their preparation and use
    Patent number: 6720342
    Abstract: The present invention relates to therapeutically active azabicyclic compounds, a method of preparing the same and to pharmaceutical or veterinary compositions comprising the compounds. The novel compounds are useful in treating a disease in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
    Type: Grant
    Filed: August 28, 2001
    Date of Patent: April 13, 2004
    Assignee: Novo Nordisk A/S
    Inventors: Lone Jeppesen, Per Sauerberg
  • Compounds, their preparation and use
    Patent number: 6703401
    Abstract: The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by clear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: March 9, 2004
    Assignees: Novo Nordisk A/S, Dr. Reddy's Research Foundation
    Inventors: Lone Jeppesen, Paul Stanley Bury, Per Sauerberg
  • Compounds, their preparation and use
    Patent number: 6683111
    Abstract: The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: January 27, 2004
    Assignees: Novo Nordisk A/S, Dr. Reddy's Research Foundation
    Inventors: Lone Jeppesen, Paul Stanley Bury, Per Sauerberg