Abstract: The disclosure provides methods for the long-term expansion of granulocyte-macrophage progenitors, the granulocyte-macrophage progenitors generated therefrom, and uses of the granulocyte-macrophage progenitors thereof.

Abstract: Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: An assistive device structure for positioning and pressure relief is provided, including a first elastic layer and a second elastic layer, which are attached by using a high-frequency encapsulation process, sealing, bagging, thermoforming, or an integrally molding process. Each of the first and second elastic layers has a bottom surface and an arc surface disposed opposite to each other. The arc surface includes two protrusions and a recess formed there in between. The two protrusions have different heights. A hollow area is disposed in the recess of the first and second elastic layers. Based on such structure, the bottom surfaces of the first and second elastic layers are attached to form the proposed assistive device structure for a user to lean against and providing multiple positioning effects and pressure relief. More than four axial directions of supporting forces are generated to effectively enhance muscle relaxation and stress relief.

Abstract: An assistive device structure for positioning and pressure relief is provided, including a first elastic layer and a second elastic layer, which are attached by using a high-frequency encapsulation process, sealing, bagging, thermoforming, or an integrally molding process. Each of the first and second elastic layers has a bottom surface and an arc surface disposed opposite to each other. The arc surface includes two protrusions and a recess formed there in between. The two protrusions have different heights. A hollow area is disposed in the recess of the first and second elastic layers. Based on such structure, the bottom surfaces of the first and second elastic layers are attached to form the proposed assistive device structure for a user to lean against and providing multiple positioning effects and pressure relief More than four axial directions of supporting forces are generated to effectively enhance muscle relaxation and stress relief.

Abstract: The disclosure provides methods for the long-term expansion of granulocyte-macrophage progenitors, the granulocyte-macrophage progenitors generated therefrom, and uses of the granulocyte-macrophage progenitors thereof.

Abstract: A method for updating a vehicle reference speed for a vehicle is disclosed. The method includes increasing brake pressure to at least one wheel of the plurality of wheels and determining, via an electronic control unit, that a first wheel speed of the at least one wheel is less than a second wheel speed of another wheel of the plurality of wheels. The method also includes estimating the vehicle reference speed of the vehicle based upon the first wheel speed of the at least one wheel.

Abstract: Systems and methods for dynamically distributing brake torque among a plurality of brakes of a vehicle are provided. In one example, a method includes detecting a braking distribution condition; calculating a weight distribution for the vehicle based on a longitudinal acceleration and a lateral acceleration associated with the vehicle to provide a calculated weight distribution; calculating a brake torque limit for each of the plurality of brakes based on the calculated weight distribution to provide calculated brake torque limits; calculating a target brake torque for each of the plurality of brakes based on a driver-demanded brake torque to provide target brake torques; and comparing the calculated brake torque limits with corresponding target brake torques.

Abstract: A method is disclosed for validating operation of a secondary braking system (SBS) of a vehicle having a plurality of brakes, by controlling the SBS and a primary braking system (PBS) of the vehicle. The method may involve using the PBS to generate a first predetermined target braking pressure in the PBS for at least a first one of the brakes, while using the SBS to generate a second predetermined target braking pressure in the SBS for at least a second one of the brakes. Actual and anticipated performance characteristics of a braking component associated with the vehicle are then observed and compared, and from the comparison a determination is made whether the SBS is operating properly.

Abstract: A method is disclosed for mitigating wheel hop of a motor vehicle. The method may involve detecting an oscillation of a wheel speed of a driven wheel of the motor vehicle of the motor vehicle. When oscillation of the wheel is detected, a low amplitude, high frequency ripple braking signal is applied to a brake caliper associated with the wheel to modulate a braking action acting on the wheel.

Abstract: A method for updating a vehicle reference speed for a vehicle is disclosed. The method includes increasing brake pressure to at least one wheel of the plurality of wheels and determining, via an electronic control unit, that a first wheel speed of the at least one wheel is less than a second wheel speed of another wheel of the plurality of wheels. The method also includes estimating the vehicle reference speed of the vehicle based upon the first wheel speed of the at least one wheel.

Abstract: Systems and methods for dynamically distributing brake torque among a plurality of brakes of a vehicle are provided. In one example, a method includes detecting a braking distribution condition; calculating a weight distribution for the vehicle based on a longitudinal acceleration and a lateral acceleration associated with the vehicle to provide a calculated weight distribution; calculating a brake torque limit for each of the plurality of brakes based on the calculated weight distribution to provide calculated brake torque limits; calculating a target brake torque for each of the plurality of brakes based on a driver-demanded brake torque to provide target brake torques; and comparing the calculated brake torque limits with corresponding target brake torques.

Abstract: A method for mitigating sway of a trailer being towed by a leading vehicle is disclosed. The method may involve using a controller of the vehicle to determine when a trailer sway condition has arisen that requires a mitigating action. The controller may be used to actuate a plurality of brakes of the vehicle, or to increase braking pressure being applied by a driver of the vehicle, when the trailer is detected as swaying toward a centerline of the vehicle from one side or another of the vehicle centerline. The controller may further be used to release the plurality of brakes, or to decrease a braking pressure being commanded by the driver, before the trailer has swayed past the vehicle centerline, and to repeatedly apply and release the vehicle brakes only while the trailer is detected as swaying toward the vehicle centerline, until the trailer sway condition has been mitigated.

Abstract: A method for mitigating sway of a trailer being towed by a leading vehicle is disclosed. The method may involve using a controller of the vehicle to determine when a trailer sway condition has arisen that requires a mitigating action. The controller may be used to actuate a plurality of brakes of the vehicle, or to increase braking pressure being applied by a driver of the vehicle, when the trailer is detected as swaying toward a centerline of the vehicle from one side or another of the vehicle centerline. The controller may further be used to release the plurality of brakes, or to decrease a braking pressure being commanded by the driver, before the trailer has swayed past the vehicle centerline, and to repeatedly apply and release the vehicle brakes only while the trailer is detected as swaying toward the vehicle centerline, until the trailer sway condition has been mitigated.

Abstract: A method is disclosed for mitigating wheel hop of a motor vehicle. The method may involve detecting an oscillation of a wheel speed of a driven wheel of the motor vehicle of the motor vehicle. When oscillation of the wheel is detected, a low amplitude, high frequency ripple braking signal is applied to a brake caliper associated with the wheel to modulate a braking action acting on the wheel.

Abstract: A method is disclosed for validating operation of a secondary braking system (SBS) of a vehicle having a plurality of brakes, by controlling the SBS and a primary braking system (PBS) of the vehicle. The method may involve using the PBS to generate a first predetermined target braking pressure in the PBS for at least a first one of the brakes, while using the SBS to generate a second predetermined target braking pressure in the SBS for at least a second one of the brakes. Actual and anticipated performance characteristics of a braking component associated with the vehicle are then observed and compared, and from the comparison a determination is made whether the SBS is operating properly.

Abstract: The present disclosure relates to a system for real time control of a wheel slip of each slipping wheel of a pair of wheels associated with an axle of a motor vehicle, simultaneously and independently with real time explicit control of said motor vehicle's acceleration provided by each non-slipping wheel associated with the axle. The system makes use of a total controller and an asymmetric controller associated with the axle of the vehicle for generating two torque signals used to control the total and asymmetric dynamics respectively of the axle, and a distributor for distributing the two said torque signals into available actuators' targets. The two said controllers each contain feedback and feed forward control elements, is operable to sense wheel slippage condition of each wheel on the axle, and augments the feedback and feed forward control based on the sensed wheel slippage conditions.

Abstract: The present disclosure relates to a system for real time control of a wheel slip of each slipping wheel of a pair of wheels associated with an axle of a motor vehicle, simultaneously and independently with real time explicit control of said motor vehicle's acceleration provided by each non-slipping wheel associated with the axle. The system makes use of a total controller and an asymmetric controller associated with the axle of the vehicle for generating two torque signals used to control the total and asymmetric dynamics respectively of the axle, and a distributor for distributing the two said torque signals into available actuators' targets. The two said controllers each contain feedback and feed forward control elements, is operable to sense wheel slippage condition of each wheel on the axle, and augments the feedback and feed forward control based on the sensed wheel slippage conditions.

Abstract: A vehicle control system includes: a non-inertial sensor arrangement configured to detect a parameter indicative of a radius of turn for the vehicle that is desired by a driver of the vehicle; a speed detection arrangement operable to detect the forward speed of the vehicle; a friction estimation arrangement, configured to provide an estimated value for the coefficient of friction between at least one tire of the vehicle and a surface over which the vehicle is driven; and a processor connected to receive signals from the non-inertial sensor arrangement, the speed detection arrangement and the friction estimation arrangement.

Abstract: A hill start assist method for a vehicle includes a vehicle-mounted controller for sensing an intention to start on an uphill slope, and converts a sensed gradient resistance into a target torque, and enables the engine to have adequate torque reserve in advance; therefore, in the subsequent start, driving wheels can obtain sufficient driving force to ensure that the vehicle will not slide backward. Furthermore, for a manual automobile, the engine torque is boosted in an early stage during a clutch release by a driver, thus accelerating the rotation speed of the engine, and avoiding, to a certain extent, engine stalling caused by a too quick or too much clutch release, compared with the situation where the engine is completely idling.

Abstract: A hill start assist method for a vehicle includes a vehicle-mounted controller for sensing an intention to start on an uphill slope, and converts a sensed gradient resistance into a target torque, and enables the engine to have adequate torque reserve in advance; therefore, in the subsequent start, driving wheels can obtain sufficient driving force to ensure that the vehicle will not slide backward. Furthermore, for a manual automobile, the engine torque is boosted in an early stage during a clutch release by a driver, thus accelerating the rotation speed of the engine, and avoiding, to a certain extent, engine stalling caused by a too quick or too much clutch release, compared with the situation where the engine is completely idling.