Patents by Inventor Loredana Fiorentino
Loredana Fiorentino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110201780Abstract: In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.Type: ApplicationFiled: March 17, 2011Publication date: August 18, 2011Applicant: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTEInventors: John C. Reed, Adam Godzik, Krzysztof Pawlowski, Loredana Fiorentino, Sug Hyung Lee, Wilfried Roth, Frank Stenner-Liewen
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Publication number: 20090011501Abstract: In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.Type: ApplicationFiled: June 5, 2008Publication date: January 8, 2009Applicant: THE BURNHAM INSTITUTEInventors: John C. Reed, Adam Godzik, Krzysztof Pawlowski, Loredana Fiorentino, Sug Hyung Lee, Wilfried Roth, Frank Stenner-Liewen
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Patent number: 6965023Abstract: In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.Type: GrantFiled: November 15, 2001Date of Patent: November 15, 2005Assignee: The Burnham InstituteInventors: John C. Reed, Adam Godzik, Krzysztof Pawlowski, Loredana Fiorentino, Sug Hyung Lee, Wilfried Roth, Frank Stenner-Liewen
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Patent number: 6953691Abstract: The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NB-ARC domains and LRR domains, encoded polypeptides, and antibodies. Also provided are methods of identifying polypeptides and agents that associate with a PAAD-domain containing polypeptide or fragment thereof, or that alter an association of a PAAD domain-containing polypeptides. Further provided are methods of identifying agents that modulate PAAD domain-mediated inhibition of NF?B activity, or modulate an activity of an NB-ARC domain of a PAAD domain-containing polypeptide. Also provided are methods of modulating NF?B transcriptional activity in a cell, and methods of altering expression of a PAAD domain-containing polypeptide in a cell.Type: GrantFiled: February 17, 2004Date of Patent: October 11, 2005Assignee: The Burnham InstituteInventors: John C Reed, Adam Godzik, Zhi-Liang Chu, Krzysztof Pawlowski, Loredana Fiorentino, Maria Eugenia Ariza, Christian Stehlik
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Publication number: 20050192427Abstract: In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.Type: ApplicationFiled: March 25, 2005Publication date: September 1, 2005Applicant: The Burnham InstituteInventors: John Reed, Adam Godzik, Krzysztof Pawlowski, Loredana Fiorentino, Sug Lee, Wilfried Roth, Frank Stenner-Liewen
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Publication number: 20040142374Abstract: The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NB-ARC domains and LRR domains, encoded polypeptides, and antibodies. Also provided are methods of identifying polypeptides and agents that associate with a PAAD-domain containing polypeptide or fragment thereof, or that alter an association of a PAAD domain-containing polypeptides. Further provided are methods of identifying agents that modulate PAAD domain-mediated inhibition of NFkB activity, or modulate an activity of an NB-ARC domain of a PAAD domain-containing polypeptide. Also provided are methods of modulating NFkB transcriptional activity in a cell, and methods of altering expression of a PAAD domain-containing polypeptide in a cell.Type: ApplicationFiled: February 17, 2004Publication date: July 22, 2004Applicant: THE BURNHAM INSTITUTE.Inventors: John C. Reed, Adam Godzik, Zhi-Liang Chu, Krzysztof Pawlowski, Loredana Fiorentino, Maria Eugenia Ariza, Christian Stehlik
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Publication number: 20030077699Abstract: The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NB-ARC domains and LRR domains, encoded polypeptides, and antibodies. Also provided are methods of identifying polypeptides and agents that associate with a PAAD-domain containing polypeptide or fragment thereof, or that alter an association of a PAAD domain-containing polypeptides. Further provided are methods of identifying agents that modulate PAAD domain-mediated inhibition of NF&kgr;B activity, or modulate an activity of an NB-ARC domain of a PAAD domain-containing polypeptide. Also provided are methods of modulating NF&kgr;B transcriptional activity in a cell, and methods of altering expression of a PAAD domain-containing polypeptide in a cell.Type: ApplicationFiled: September 25, 2001Publication date: April 24, 2003Inventors: John C. Reed, Adam Godzik, Zhi-Liang Chu, Krzysztof Pawlowski, Loredana Fiorentino, Maria Eugenia Ariza, Christian Stehlik
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Publication number: 20030049702Abstract: In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.Type: ApplicationFiled: November 15, 2001Publication date: March 13, 2003Inventors: John C. Reed, Adam Godzik, Krzysztof Pawlowski, Loredana Fiorentino, Sug Hyung Lee, Wilfried Roth, Frank Stenner-Liewen