Patents by Inventor Loretta McNatt

Loretta McNatt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNAi Inhibition of Serum Amyloid A For Treatment of Glaucoma
    Publication number: 20120122961
    Abstract: RNA interference is provided for inhibition of serum amyloid A mRNA expression in glaucomas involving SAA expression.
    Type: Application
    Filed: January 31, 2012
    Publication date: May 17, 2012
    Applicant: NOVARTIS AG
    Inventors: Abbot F. Clark, Wan-Heng Wang, Loretta McNatt
  • RNAi Inhibition of Serum Amyloid A For Treatment of Glaucoma
    Publication number: 20110054008
    Abstract: RNA interference is provided for inhibition of serum amyloid A mRNA expression in glaucomas involving SAA expression.
    Type: Application
    Filed: October 26, 2010
    Publication date: March 3, 2011
    Applicant: ALCON, INC.
    Inventors: Abbot F. Clark, Wan-Heng Wang, Loretta McNatt
  • Diagnostics and therapeutics for glaucoma
    Patent number: 7807355
    Abstract: Methods and compositions for diagnosing and treating glaucoma are disclosed.
    Type: Grant
    Filed: January 6, 2006
    Date of Patent: October 5, 2010
    Assignees: Alcon, Inc., University of Iowa Research Foundation
    Inventors: Abbot F. Clark, John Fingert, Loretta McNatt, Edwin M. Stone, Wan-Heng Wang
  • RNAi Inhibition of Serum Amyloid A For Treatment of Glaucoma
    Publication number: 20100152279
    Abstract: RNA interference is provided for inhibition of serum amyloid A mRNA expression in glaucomas involving SAA expression.
    Type: Application
    Filed: February 25, 2010
    Publication date: June 17, 2010
    Applicant: ALCON, INC.
    Inventors: Abbot F. Clark, Wan-Heng Wang, Loretta McNatt
  • Diagnostics and Therapeutics For Glaucoma
    Publication number: 20090226425
    Abstract: Methods and compositions for diagnosing and treating glaucoma are disclosed.
    Type: Application
    Filed: April 9, 2009
    Publication date: September 10, 2009
    Applicants: ALCON, INC., UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Abbot F. Clark, John Fingert, Loretta McNatt, Edwin M. Stone, Wan-Heng Wang
  • Use of Serum Amyloid A Gene in Diagnosis and Treatment of Glaucoma and Identification of Anti-Glaucoma Agents
    Publication number: 20090036371
    Abstract: The present invention provides compositions and methods for treating glaucoma, methods for diagnosing glaucoma, and methods for identifying agents which may be useful in the treatment of glaucoma. More specifically, the present invention describes the use of agents that modulate the expression of serum amyloid A.
    Type: Application
    Filed: February 27, 2008
    Publication date: February 5, 2009
    Applicant: ALCON, INC.
    Inventors: Abbot F. CLARK, Wan-Heng WANG, Loretta MCNATT
  • Use of serum amyloid a gene in diagnosis and treatment of glaucoma and identification of anti-glaucoma agents
    Patent number: 7357931
    Abstract: The present invention provides compositions and methods for treating glaucoma, methods for diagnosing glaucoma, and methods for identifying agents which may be useful in the treatment of glaucoma. More specifically, the present invention describes the use of agents that modulate the expression of serum amyloid A.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: April 15, 2008
    Assignee: Alcon, Inc.
    Inventors: Abbot F. Clark, Wan-Heng Wang, Loretta McNatt
  • SUPEROXIDE DISMUTASE-2 EXPRESSION AND MODULATION FOR GLAUCOMA DIAGNOSIS AND THERAPY
    Publication number: 20080085878
    Abstract: The present invention concerns a method for diagnosing or monitoring elevated intraocular pressure or glaucoma in a patient comprising providing a biological sample from the patient and measuring the expression level of a superoxide dismutase-2 (SOD-2) gene in the biological sample. The present invention also concerns methods for treating glaucoma or elevated intraocular pressure in a patient comprising administering to a patient an effective amount of an agent that modulates SOD-2 expression or SOD-2 activity.
    Type: Application
    Filed: February 28, 2007
    Publication date: April 10, 2008
    Applicant: ALCON MANUFACTURING, LTD.
    Inventors: Wan-Heng WANG, Loretta McNatt, Abbot CLARK, Peter KLIMKO
  • Use of Serum Amyloid A Gene in Diagnosis and Treatment of Glaucoma and Identification of Anti-Glaucoma Agents
    Publication number: 20070208043
    Abstract: The present invention provides compositions and methods for treating glaucoma, methods for diagnosing glaucoma, and methods for identifying agents which may be useful in the treatment of glaucoma. More specifically, the present invention describes the use of agents that modulate the expression of serum amyloid A.
    Type: Application
    Filed: December 22, 2006
    Publication date: September 6, 2007
    Applicant: ALCON, INC.
    Inventors: Abbot Clark, Wan-Heng Wang, Loretta McNatt
  • RNAi-mediated inhibition of Frizzled Related Protein-1 for treatment of glaucoma
    Publication number: 20060223773
    Abstract: RNA interference is provided for inhibition of Frizzled Related Protein-1 mRNA expression, in particular, for treating patients having glaucoma or at risk of developing glaucoma.
    Type: Application
    Filed: March 10, 2006
    Publication date: October 5, 2006
    Applicant: Alcon, Inc.
    Inventors: Abbot Clark, Wan-Heng Wang, Loretta McNatt, Jon Chatterton
  • Diagnostics and therapeutics for glaucoma
    Publication number: 20060216732
    Abstract: Methods and compositions for diagnosing and treating glaucoma are disclosed.
    Type: Application
    Filed: January 6, 2006
    Publication date: September 28, 2006
    Inventors: Abbot Clark, John Fingert, Loretta McNatt, Edwin Stone, Wan-Heng Wang
  • RNAi inhibition of serum amyloid a for treatment of glaucoma
    Publication number: 20060172961
    Abstract: RNA interference is provided for inhibition of serum amyloid A mRNA expression in glaucomas involving SAA expression.
    Type: Application
    Filed: December 19, 2005
    Publication date: August 3, 2006
    Applicant: Alcon, Inc.
    Inventors: Abbot Clark, Wan-Heng Wang, Loretta McNatt
  • Method of reducing intraocular pressure and treating glaucoma
    Publication number: 20060154981
    Abstract: The use of 5,6,7-trihydroxyheptanoic acid and analogs for the treatment of ocular hypertension and glaucoma is disclosed.
    Type: Application
    Filed: January 12, 2006
    Publication date: July 13, 2006
    Inventors: Peter Klimko, Mark Hellberg, Wan-Heng Wang, Abbot Clark, Loretta McNatt
  • Agents which regulate, inhibit, or modulate the activity and/or expression of formyl peptide receptors as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies
    Publication number: 20060134171
    Abstract: The present invention provides a method for lowering intraocular pressure and providing neuroprotection to a patient in need thereof by administering a therapeutically effective amount of at least one non-nucleotide or non-protein agent that inhibits expression and/or signaling of FPR.
    Type: Application
    Filed: December 1, 2005
    Publication date: June 22, 2006
    Inventors: Loretta McNatt, Wan-Heng Wang, Abbot Clark
  • Diagnostics and therapeutics for glaucoma
    Patent number: 7033755
    Abstract: Methods and compositions for diagnosing and treating glaucoma are disclosed.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: April 25, 2006
    Assignees: Alcon, Inc., University of Iowa Research Foundation
    Inventors: Abbot F. Clark, John Fingert, Loretta McNatt, Edwin M. Stone, Wan-Heng Wang
  • Diagnosis and treatment of glaucoma and methods for discovering new glaucoma therapeutic agents based on the wnt/ca2+ signaling pathway
    Publication number: 20050170430
    Abstract: The present invention provides methods for diagnosing and treating glaucoma and identifying agents potentially useful for treating glaucoma. The invention further provides compositions useful for treating glaucoma.
    Type: Application
    Filed: April 30, 2003
    Publication date: August 4, 2005
    Inventors: Abbot Clark, Wan-Heng Wang, Loretta McNatt
  • Diagnosis and treatment of glaucoma and methods for discovering new glaucoma therapeutic agents based on the wnt/planar cell polarity (pcp) signaling pathway
    Publication number: 20050164907
    Abstract: The present invention provides methods for diagnosing and treating glaucoma and identifying agents potentially useful for treating glaucoma. The invention further provides compositions useful for treating glaucoma.
    Type: Application
    Filed: April 30, 2003
    Publication date: July 28, 2005
    Inventors: Abbot Clark, Wan-Heng Wang, Loretta McNatt
  • Use of serum amyloid a gene in diagnosis and treatment of glaucoma and identification of anti-glaucoma agents
    Publication number: 20050153927
    Abstract: The present invention provides compositions and methods for treating glaucoma, methods for diagnosing glaucoma, and methods for identifying agents which may be useful in the treatment of glaucoma. More specifically, the present invention describes the use of agents that modulate the expression of serum amyloid A.
    Type: Application
    Filed: December 1, 2004
    Publication date: July 14, 2005
    Inventors: Abbot Clark, Wan-Heng Wang, Loretta McNatt
  • Use of inhibitors of TGF-beta's functions to ameliorate ocular pathology
    Publication number: 20020115589
    Abstract: Compositions comprising at least one TGF-&bgr; modulator for treating TGF-&bgr; mediated ocular pathologies are disclosed. Methods directed to the treatment of these pathologies, and in particular, glaucoma, ocular hypertension, PVR, secondary cataract, corneal haze and glaucoma filtration surgery bleb failure are also disclosed.
    Type: Application
    Filed: November 14, 2001
    Publication date: August 22, 2002
    Inventors: Jon C. Nixon, Henry T. Steely, Herman M. Kunkle, Loretta McNatt
  • Diagnostics and therapeutics for glaucoma
    Publication number: 20020049177
    Abstract: Methods and compositions for diagnosing and treating glaucoma are disclosed.
    Type: Application
    Filed: February 28, 2001
    Publication date: April 25, 2002
    Inventors: Abbot F. Clark, John Fingert, Loretta McNatt, Edwin Stone, Wan-Heng Wang