Patents by Inventor Lori S. Friedman

Lori S. Friedman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USES OF GLUCOCORTICOID RECEPTOR (GR) ANTAGONIST AND ANDROGEN RECEPTOR (AR) DEGRADER COMBINATIONS
    Publication number: 20230302014
    Abstract: Disclosed herein are methods of treating prostate cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of (i) a glucocorticoid receptor (GR) antagonist and (ii) an androgen receptor (AR) degrader.
    Type: Application
    Filed: August 3, 2021
    Publication date: September 28, 2023
    Inventors: Haiying ZHOU, Lori S. FRIEDMAN, Shravani BARKUND, Anneleen DAEMEN
  • EEF2K as modifiers of the PTEN/AKT pathway and methods of use
    Patent number: 8679763
    Abstract: Human EEF2K genes are identified as modulators of the PTEN/AKT pathway and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT comprising screening for agents that modulate the activity of EEF2K are provided.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: March 25, 2014
    Assignee: Exelixis, Inc.
    Inventors: Arthur Brace, Robert A. Blake, Lori S. Friedman, Lynn Margaret Bjerke, Kevin M. Ward, Susana Nieto-Bergman
  • EYA2S As Modifiers of the PTEN/AKT Pathway and Methods of Use
    Publication number: 20110135629
    Abstract: Human MPTENAKT genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of MPTENAKT are provided.
    Type: Application
    Filed: June 20, 2006
    Publication date: June 9, 2011
    Applicant: EXELIXIS, INC.
    Inventors: Arthur Brace, Margaret Lynn Bjerke, Susana Nieto-Bergman, Lori S. Friedman, Kevin Ward, Robert A. Blake
  • P4HAS as modifiers of the IGFR pathway and methods of use
    Patent number: 7888048
    Abstract: Human P4HA genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of P4HA are provided.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: February 15, 2011
    Assignee: Exelixis, Inc.
    Inventors: Lori S. Friedman, Helen Francis-Lang, Annette L. Parks, Kenneth James Shaw, Timothy S. Heuer, Lynn Margaret Bjerke
  • GALK1S AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE
    Publication number: 20100183583
    Abstract: Human GALK1 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of GALK1 are provided.
    Type: Application
    Filed: June 20, 2006
    Publication date: July 22, 2010
    Applicant: EXELIXIS, INC.
    Inventors: Arthur Brace, Margaret Lynn Bjerke, Susana Nieto-Bergman, Lori S. Friedman, Kevin Ward, Robert A. Blake
  • CDC6S AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE
    Publication number: 20100122354
    Abstract: Human CDC6 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of CDC6 are provided.
    Type: Application
    Filed: June 20, 2006
    Publication date: May 13, 2010
    Applicant: EXELIXIS, INC.
    Inventors: Arthur Brace, Margaret Lynn Bjerke, Susana Nieto-Bergman, Lori S. Friedman, Kevin Ward, Robert A. Blake
  • Pfks as modifiers of the igfr pathway and methods of use
    Publication number: 20090142272
    Abstract: Human PFK genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of PFK are provided.
    Type: Application
    Filed: June 20, 2005
    Publication date: June 4, 2009
    Applicant: Exelixis, Inc.
    Inventors: Lori S. Friedman, Helen Francis-Lang, Annette L. Parks, Kenneth James Shaw, Lynn Margaret Bjerke, Timothy S. Heuer
  • GALNTS AS MODIFIERS OF THE IGFR PATHWAY AND METHODS OF USE
    Publication number: 20090028844
    Abstract: Human MIGFR genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of MIGFR are provided.
    Type: Application
    Filed: June 20, 2005
    Publication date: January 29, 2009
    Applicant: EXELIXIS, INC.
    Inventors: Lori S. Friedman, Helen Francis-Lang, Annette L. Parks, Kenneth James Shaw, Timothy S. Heuer, Lynn Margaret Bjerke
  • P4HAS AS MODIFIERS OF THE IGFR PATHWAY AND METHODS OF USE
    Publication number: 20090025096
    Abstract: Human P4HA genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of P4HA are provided.
    Type: Application
    Filed: June 20, 2005
    Publication date: January 22, 2009
    Applicant: EXELIXIS, INC.
    Inventors: Lori S. Friedman, Helen Francis-Lang, Annette L. Parks, Kenneth James Shaw, Timothy S. Heuer, Lynn Margaret Bjerke
  • SPHKS as modifiers of the p53 pathway and methods of use
    Publication number: 20080241131
    Abstract: Human SPHK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SPHK are provided.
    Type: Application
    Filed: April 3, 2008
    Publication date: October 2, 2008
    Applicant: Exelixis Inc.
    Inventors: Lori S. Friedman, Gregory D. Plowman, Michael R. Costa, Danxi Li, Roel P. Funke, Tak Hung
  • Eef2k as Modifiers of the Pten/Akt Pathway and Methods of Use
    Publication number: 20080193438
    Abstract: Human EEF2K genes are identified as modulators of the PTEN/AKT pathway and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT comprising screening for agents that modulate the activity of EEF2K are provided.
    Type: Application
    Filed: March 10, 2006
    Publication date: August 14, 2008
    Applicant: EXELIXIS INC.
    Inventors: Arthur Brace, Robert A. Blake, Lori S. Friedman, Lynn Margaret Bjerke, Kevin M. Ward, Susana Nieto-Bergman