Patents by Inventor Louis Grenier

Louis Grenier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Boronic ester and acid compounds, synthesis and uses
    Patent number: 7119080
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: October 10, 2006
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross L. Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Formulation of boronic acid compounds
    Patent number: 7109323
    Abstract: The invention relates to the formulation of pharmaceutical compounds. More particularly, the invention provides stable, pharmaceutically acceptable compositions prepared from boronic acid compounds and methods for preparing the compositions. The invention also provides novel boronate ester compounds. The invention further provides boronic acid anhydride compounds useful in the methods of the invention.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: September 19, 2006
    Assignees: The United States of America as represented by the Department of Health and Human Services, Millennium Pharmaceutical, Inc.
    Inventors: Louis Plamondon, Louis Grenier, Julian Adams, Shanker Lal Gupta
  • Substituted beta carbolines
    Publication number: 20060166978
    Abstract: The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I, which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of I?B kinase is involved.
    Type: Application
    Filed: March 28, 2006
    Publication date: July 27, 2006
    Inventors: Olaf Ritzeler, Alfredo Castro, Louis Grenier, Francois Soucy, Wayne Hancock, Hormoz Mazdiyasni, Vito Palombella, Julian Adams
  • Boronic ester and acid compounds, synthesis and uses
    Publication number: 20060122390
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Application
    Filed: October 17, 2005
    Publication date: June 8, 2006
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Substituted beta-carbolines
    Patent number: 7026331
    Abstract: The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I, which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of I?B kinase is involved.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: April 11, 2006
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Olaf Ritzeler, Alfredo Castro, Louis Grenier, Francois Soucy, Wayne W. Hancock, Hormoz Mazdiyasni, Vito Palombella, Julian Adams
  • Analogs of benzoquinone-containing ansamycins and methods of use thereof
    Publication number: 20060019941
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Application
    Filed: July 13, 2005
    Publication date: January 26, 2006
    Applicant: Infinity Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yun Gao, Asimina Evangelinos, Louis Grenier, Roger Pak, James Porter, James Wright
  • Analogs of benzoquinone-containing ansamycins and methods of use thereof
    Publication number: 20060019939
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Application
    Filed: April 13, 2005
    Publication date: January 26, 2006
    Inventors: Julian Adams, Yun Gao, Asimina Evangelinos, Louis Grenier, Roger Pak, James Porter, James Wright
  • Analogs of benzoquinone-containing ansamycins and methods of use thereof
    Publication number: 20060014731
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Application
    Filed: April 14, 2005
    Publication date: January 19, 2006
    Inventors: Julian Adams, Yun Gao, Asimina Georges Evangelinos, Louis Grenier, Roger Pak, James Porter, James Wright
  • Analogs of benzoquinone-containing ansamycins and methods of use thereof
    Publication number: 20050288269
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Application
    Filed: April 14, 2005
    Publication date: December 29, 2005
    Inventors: Julian Adams, Yun Gao, Asimina Georges Evangelinos, Louis Grenier, Roger Pak, James Porter, James Wright
  • Formulation of boronic acid compounds
    Publication number: 20050282742
    Abstract: The invention relates to the formulation of pharmaceutical compounds. More particularly, the invention provides stable, pharmaceutically acceptable compositions prepared from boronic acid compounds and methods for preparing the compositions. The invention also provides novel boronate ester compounds. The invention further provides boronic acid anhydride compounds useful in the methods of the invention.
    Type: Application
    Filed: July 19, 2005
    Publication date: December 22, 2005
    Applicants: Government of the USA, represented by the Secretary,Dept. of Health and Human Services, Millennium Parmaceuticals, Inc.
    Inventors: Louis Plamondon, Louis Grenier, Julian Adams, Shanker Gupta
  • Analogs of benzoquinone-containing ansamycins and methods of use thereof
    Publication number: 20050227955
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Application
    Filed: December 23, 2004
    Publication date: October 13, 2005
    Inventors: Julian Adams, Yun Gao, Asimina Evangelinos, Louis Grenier, Roger Pak, James Porter, James Wright
  • Boronic ester and acid compounds, synthesis and uses
    Publication number: 20040167332
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Application
    Filed: December 8, 2003
    Publication date: August 26, 2004
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Formulation of boronic acid compounds
    Publication number: 20040138411
    Abstract: The invention relates to the formulation of pharmaceutical compounds. More particularly, the invention provides stable, pharmaceutically acceptable compositions prepared from boronic add compounds and methods for preparing the compositions. The invention also provides novel boronate ester compounds. The invention further provides boronic add anhydride compounds useful in the methods of the invention.
    Type: Application
    Filed: December 23, 2003
    Publication date: July 15, 2004
    Applicants: Government of U.S.A., represented by the Secretary Department of Health & Human Services, Millennium Pharmaceuticals, Inc.
    Inventors: Louis Plamondon, Louis Grenier, Julian Adams, Shanker Lal Gupta
  • Substituted beta carbolines
    Publication number: 20040110759
    Abstract: The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I, 1
    Type: Application
    Filed: July 28, 2003
    Publication date: June 10, 2004
    Applicant: AVENTIS PHARMA DEUTSCHLAND GMBH
    Inventors: Olaf Ritzeler, Alfredo Castro, Louis Grenier, Francois Soucy, Wayne W. Hancock, Hormoz Mazdiyasni, Vito Palombella, Julian Adams
  • Boronic ester and acid compounds, synthesis and uses
    Patent number: 6747150
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: June 8, 2004
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Formulation of boronic acid compounds
    Patent number: 6699835
    Abstract: The invention relates to the formulation of pharmaceutical compounds. More particularly, the invention provides stable, pharmaceutically acceptable compositions prepared from boronic acid compounds and methods for preparing the compositions. The invention also provides novel boronate ester compounds. The invention further provides boronic acid anhydride compounds useful in the methods of the invention.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: March 2, 2004
    Assignees: The United States of America as represented by the Department of Health and Human Services, Millennium Pharmaceuticals, Inc.
    Inventors: Louis Plamondon, Louis Grenier, Julian Adams, Shanker Lal Gupta
  • Boronic ester and acid compounds, synthesis and uses
    Publication number: 20030199561
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Application
    Filed: March 19, 2003
    Publication date: October 23, 2003
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Substituted beta carbolines
    Patent number: 6627637
    Abstract: The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I, which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of I&kgr;B kinase is involved.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: September 30, 2003
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Olaf Ritzeler, Alfredo Castro, Louis Grenier, Francois Soucy, Wayne W. Hancock, Hormoz Mazdiyashi, Vito Palombella, Julian Adams
  • Boronic ester and acid compositions
    Patent number: 6617317
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: September 9, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Boronic ester and acid compounds, synthesis and uses
    Patent number: 6548668
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Grant
    Filed: March 18, 2002
    Date of Patent: April 15, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon