Patents by Inventor Louis L. Skaletzky

Louis L. Skaletzky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds useful to treat retroviral infections
    Patent number: 6169181
    Abstract: The present invention relates to compounds of formula I and II which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus.
    Type: Grant
    Filed: November 9, 1998
    Date of Patent: January 2, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: Karen Rene Romines, Gordon L. Bundy, Theresa M. Schwartz, Ruben A. Tommasi, Joseph W. Strohbach, Steven Ronald Turner, Suvit Thaisrivongs, Paul Adrian Aristoff, Paul D. Johnson, Harvey Irving Skulnick, Louis L. Skaletzky, David John Anderson, Joel Morris, Ronald B. Gammill, George P. Luke
  • Bis-sulfonamides hydroxamic acids as MMP inhibitors
    Patent number: 5859061
    Abstract: The present invention provides a compound of formula I ##STR1## or pharmaceutically acceptable salts thereof wherein R.sup.1 and R.sup.2 are the same or different and are C.sub.1-10 alkyl, phenyl, hetero-aryl, or phenyl substituted with C.sub.1-4 alkyl, OR.sup.3, NHR.sup.3, CONHR.sup.3, NHCOR.sup.3, or halo; wherein R.sup.3 is H, or C.sub.1-4 alkyl; and n is 1, 2, 3, 4, 5, or 6. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.
    Type: Grant
    Filed: January 9, 1998
    Date of Patent: January 12, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventors: Eric Jon Jacobsen, Louis L. Skaletzky
  • Pyranone compounds useful to treat retroviral infections
    Patent number: 5852195
    Abstract: The present invention relates to compounds of formulae (I) and (II) which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl?b!pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus, wherein R.sub.10 and R.sub.20 taken together are formulae (III) and (IV).
    Type: Grant
    Filed: November 4, 1996
    Date of Patent: December 22, 1998
    Assignee: Pharmacia & Upjohn Company
    Inventors: Karen Rene Romines, Gordon L. Bundy, Theresa M. Schwartz, Ruben A. Tommasi, Joseph W. Strohbach, Steven Ronald Turner, Suvit Thaisrivongs, Paul Adrian Aristoff, Paul D. Johnson, Harvey Irving Skulnick, Louis L. Skaletzky, David John Anderson, Joel Morris, Ronald B. Gammill, George P. Luke
  • Diuretic 2,6-diaryl-4-pyridine carboxylic acids
    Patent number: 4474791
    Abstract: The present invention provides novel methods of inducing diuresis and/or an antihypertensive effect employing certain 2,6-diaryl-4-pyridinecarboxylic acid derivatives. Also provided are novel compositions to be used in these methods.
    Type: Grant
    Filed: December 13, 1982
    Date of Patent: October 2, 1984
    Assignee: The Upjohn Company
    Inventor: Louis L. Skaletzky
  • Diuretic 2,6-diaryl-4-pyridine carboxylic acids
    Patent number: 4377586
    Abstract: The present invention provides a novel method of inducing diuresis by administering certain 2,6-diaryl-4-pyridinecarboxylic acid derivatives. Also provided are novel compounds and pharmaceutical compositions to be used in this method.
    Type: Grant
    Filed: April 30, 1981
    Date of Patent: March 22, 1983
    Assignee: The Upjohn Company
    Inventor: Louis L. Skaletzky
  • Compositions and method of using quinolylaminobenzoylpiperazino-1-oxides
    Patent number: 4057633
    Abstract: Novel compounds of the formula: ##STR1## are disclosed with the corresponding hydrates and pharamceutically acceptable acid addition salts thereof, wherein R.sub.1 is halogen, lower alkyl, or trifluoromethyl; R.sub.2 is lower alkyl, substituted or unsubstituted phenyl or benzyl and R.sub.3 is hydrogen. The novel compounds are useful for the treatment of hypertension and anxiety in mammals, including humans.Disclosed also are compositions containing the novel compounds of the invention and methods of their use in the treatment of hypertension and anxiety.
    Type: Grant
    Filed: August 18, 1976
    Date of Patent: November 8, 1977
    Assignee: The Upjohn Company
    Inventors: Charles E. Coverdale, Louis L. Skaletzky
  • Antiviral quinazoline compositions and methods of use
    Patent number: 4010269
    Abstract: 2-(1,3-Diaza-2-cycloalken-2-ylamino)quinazolines and substituted compounds are compounded into local and topical compositions for the treatment of viruses.
    Type: Grant
    Filed: June 16, 1975
    Date of Patent: March 1, 1977
    Assignee: The Upjohn Company
    Inventors: Harold E. Renis, Louis L. Skaletzky
  • Adamantyl containing guanidines
    Patent number: 4007181
    Abstract: Novel compounds of FIG.
    Type: Grant
    Filed: February 11, 1974
    Date of Patent: February 8, 1977
    Assignee: The Upjohn Company
    Inventors: Donald W. DuCharme, Louis L. Skaletzky
  • Quinolylaminobenzoylpiperazine-1-oxides
    Patent number: 3992382
    Abstract: Novel compounds of the formula: ##SPC1##Are disclosed with the corresponding hydrates and pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 is halogen, lower alkyl, or trifluoromethyl; R.sub.2 is lower alkyl, substituted or unsubstituted phenyl or benzyl and R.sub.3 is hydrogen. The novel compounds are useful for the treatment of hypertension and anxiety in mammals, including humans.Disclosed also are compositions containing the novel compounds of the invention and methods of their use in the treatment of hypertension and anxiety.
    Type: Grant
    Filed: September 23, 1974
    Date of Patent: November 16, 1976
    Assignee: The Upjohn Company
    Inventors: Charles E. Coverdale, Louis L. Skaletzky