Patents by Inventor Louis N. Gastinel

Louis N. Gastinel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Soluble mammal-derived Fc receptor which binds at a pH ranging from about 5.5 to 6.5 and releases at a pH ranging from about 7.5 to 8.5
    Patent number: 5623053
    Abstract: The present invention pertains to a new composition of matter in the form of a soluble Fc receptor (pHsFcR) is created. The pHsFcR has a pH-determinable binding capability for at least one antibody or complex thereof. The pHsFcR is produced using the cDNA for a transmembrane, pH-determinable Fc receptor found in nature which has the capability of binding to at least one antibody or complex thereof. The most preferred embodiment of the present invention is a secreted form of pHsFcR which is produced using a modified cDNA of the transmembrane Fc receptor; the modified cDNA is obtained by the creation of a new in-frame stop codon and the deletion of the DNA sequence encoding the transmembrane (and typically the cytoplasmic) domain of the transmembrane Fc receptor. This creates a new gene that encodes a completely soluble protein consisting of the extracellular domains of the transmembrane Fc receptor.
    Type: Grant
    Filed: January 14, 1993
    Date of Patent: April 22, 1997
    Assignee: California Institute of Technology
    Inventors: Louis N. Gastinel, Pamela J. Bjorkman