Abstract: Disclosed are methods and systems using liquid chromatography/tandem mass spectrometry (LC-MS/MS) for the analysis of endogenous biomarkers isolated from biological samples. In certain embodiments, the samples comprise dried body fluids such as dried plasma.

Abstract: The present invention relates to the provision of micron or sub-micron sized particles formed from one or more water-soluble crystals comprising a surface coating comprising one or more bioactive molecules wherein the particles are prepared such that in use the release of the bioactive molecule(s) is/are delayed and/or continually released over a period of time. Processes for the preparation of said particles, as well as the particles themselves are described, as well as uses of the particles.

Abstract: The present invention relates to the provision of micron or sub-micron sized particles formed from one or more water-soluble crystals comprising a surface coating comprising one or more bioactive molecules wherein the particles are prepared such that in use the release of the bioactive molecule(s) is/are delayed and/or continually released over a period of time. Processes for the preparation of said particles, as well as the particles themselves are described, as well as uses of the particles.

Abstract: Apparatus for determining the pulse width of ultra-short light pulses of an input repetitive light pulse signal comprises a two-photon absorption detector (2) in the form of a microcavity (3) having an active region (4) located between top and bottom distributed Bragg reflectors (5,6). An optical fibre cable 16 directs the input light pulse signal combined with a reference repetitive light pulse signal normal to an incident surface (8) of the detector (2). The input light pulse signal is split in a polarisation light splitter (19) to form the reference light pulse signal which is passed through a delay line (23) to a polarisation light combiner (20) to be combined with the input light pulse signal, and directed at the incident surface (8) by the optical fibre cable (16). The delay line (23) is operated for alternately bringing the respective light pulses of the input and reference light pulse signals into and out of phase with each other to produce a pulsed photocurrent in the microcavity (3).